Fipronil and Other Pyrazole Insecticides Induce Amyloid-β42 Production

March 7, 2018 - Roscoff, France – A new study led by Laurent Meijer of ManRos Therapeutics shows that some pyrazole insecticides, of which fipronil is an archetype, trigger enhanced in vitro production of Aβ42/Aβ43 over Aβ40 amyloid peptides in a cell-free, highly purified preparation of γ-secretase, in various cell lines and in neurons differentiated from human-induced pluripotent stem cells (iPSCs) from a healthy or a familial Alzheimer’s disease (AD) patient with the APP K724N mutation. Findings are published in the Journal of Alzheimer’s Disease. More...

March 7, 2018

International Group of Spina Bifida Experts Shapes Future Research and Shares Insights for Practical Care

March 1, 2018 - A Special Issue of the Journal of Pediatric Rehabilitation Medicine is designed to inform and inspire researchers and clinicians caring for patients with this complex condition More...

March 1, 2018

Data Detectives Shift Suspicions in Alzheimer’s from Usual Suspect to Inside Villain

February 21, 2018 - Atlanta, US – The mass pursuit of a conspicuous suspect in Alzheimer’s disease may have encumbered research success for decades. Now, a new data analysis that has untangled evidence amassed in years of Alzheimer’s studies encourages researchers to refocus their investigations. More...

February 21, 2018

e-Health Can Support Healthy Ageing and Help Preventing Cardiovascular Disease and Dementia in Elderly People

February 20, 2018 - Kuopio, Finland – An innovative e-health solution, based on an interactive internet platform, has been developed to support senior citizens in improving their lifestyle to prevent cardiovascular disease, cognitive decline and dementia. More...

February 20, 2018