What’s Ahead for People with Disabilities in the Post-Pandemic Workplace?

Experts report on employment and vocational rehabilitation considerations for people with disabilities during and after the COVID-19 pandemic across health, work, and education in this special issue of the Journal of Vocational Rehabilitation

February 26, 2021 - Amsterdam – COVID-19 has wrought havoc on the global economy and the world’s public health systems. People with disabilities are more likely to suffer severe cases of the disease. Experts advocate in this special issue of the Journal of Vocational Rehabilitation that vocational rehabilitation across the major life phases of health, work, and education must focus on access to technology and home-based employment and ensure people with disabilities are prepared for the new global workplace. More...

February 26, 2021

Spinal Fluid of People with Alzheimer’s Risk Gene Signals Inflammation

Fewer circulating inflammatory proteins could signal that they collect in the brain

February 16, 2021 - Durham, NC, USA – People who have a gene variant associated with an increased risk of developing Alzheimer’s disease also tend to have changes in the fluid around their brain and spinal cord that are detectable years before symptoms arise, according to new research from Duke Health. The work found that in people who carry the APOE4 gene variant, which is found in roughly 25 percent of the population, the cerebrospinal fluid contains lower levels of certain inflammatory molecules. This raises the possibility that these inflammatory molecules may be collecting in the brain where they may be damaging synapses, rather than floating freely in the cerebrospinal fluid. More...

February 16, 2021

Insights into the Role of DNA Repair and Huntington’s Disease Gene Mutation Open New Avenues for Drug Discovery

A special issue of the Journal of Huntington’s Disease focusing on recent genetic advances in the disease synthesizes the latest research and has the potential to serve as a catalyst to improve patient care and outcomes

February 11, 2021 - Amsterdam, NL – Recent genetic data from patients with Huntington’s disease (HD) show that DNA repair is an important factor that determines how early or late the disease occurs in individuals who carry the expanded CAG repeat in the HTT gene that causes HD. The processes of DNA repair further expand the CAG repeats in HTT in the brain implicated in pathogenesis and disease progression. This special issue of the Journal of Huntington’s Disease (JHD) is a compendium of new reviews on topics ranging from the discovery of somatic CAG repeat expansion in HD, to our current understanding of the molecular mechanisms involved and the development of potential new therapies targeting these mechanisms. More...

February 11, 2021

Adult Neurogenesis May Hold Clues for More Effective Treatment of Alcoholism

New research and analysis examine how alcohol exposure impacts many aspects of neuroplasticity in a special issue of Brain Plasticity

February 10, 2021 - Amsterdam, NL – Neuroplasticity, the remarkable ability of the brain to modify and reorganize itself, is affected by or in response to excessive alcohol, whether through individual consumption or exposure in the womb. It is now well accepted that the birth and integration of new neurons continue beyond development and into adulthood. New discoveries and insights on how alcohol impacts this and other plastic processes are discussed in Alcohol and Neural Plasticity, a special issue of Brain Plasticity. More...

February 10, 2021