New Study Expands Evaluation of Gene Therapy for Spinal Muscular Atrophy

Treatment with onasemnogene abeparvovec in a broader group of patients than clinical trials is associated with an immune response that needs careful monitoring, however there were no long-term side effects, report scientists in the Journal of Neuromuscular Diseases

April 6, 2021 - Amsterdam, NL – The rarity of spinal muscular atrophy (SMA) means that promising new treatments may be tested in only a limited spectrum of patients before approval. Investigators evaluated a newly approved drug, onasemnogene abeparvovec, in a broader spectrum of patients in order to obtain expanded data on its side effects profile. They report in the Journal of Neuromuscular Diseases that the drug is associated with an immune response against the adeno-associated viral vector and needs careful monitoring, but showed no long-term adverse effects. More...

April 6, 2021

Dementia Death Risk is Higher Among the Socioeconomically Deprived

March 31, 2021 - London, UK – A large proportion of dementia deaths in England and Wales may be due to socioeconomic deprivation, according to new research led by Queen Mary University of London. The team also found that socioeconomic deprivation was associated with younger age at death with dementia, and poorer access to accurate diagnosis. Dementia is the leading cause of death in England and Wales, even during the COVID-19 pandemic, and is the only disease in the top ten causes of death without effective treatment. More...

March 31, 2021

“Metamorphosis” Is Needed in Entrepreneurship and Management, Pioneering Economist Says

Prof. Milan Zeleny addresses the driving forces of disequilibrium in contemporary human systems and suggests new systems to help them evolve and thrive in Human Systems Management

March 23, 2021 - Amsterdam, NL – The COVID-19 pandemic has had a profound impact on our world, with disequilibrium, uncertainty, and human suffering making it difficult to envision a human, societal and individual future. Milan Zeleny, PhD, Professor Emeritus of Management Systems, Fordham University, New York, NY, USA, and world-recognized authority on decision making, productivity, knowledge management, and more recently the corporation as a living organism, says that “COVID-19 is rapidly changing from a cause to one of the symptoms of an increasingly unhinged world.” More...

March 23, 2021

The Important Role of Music in Neurorehabilitation: Filling in Critical Gaps

Experts highlight current gaps in clinical applications of music therapy in this theme issue of NeuroRehabilitation

March 10, 2021 - Amsterdam, NL – Music-based interventions have become a core ingredient of effective neurorehabilitation in the past 20 years thanks to the growing body of knowledge. In this theme issue of Neurorehabilitation, experts in the field highlight some of the current critical gaps in clinical applications that have been less thoroughly investigated, such as post-stroke cognition, traumatic brain injury, and autism and specific learning disabilities. More...

March 10, 2021