Newly Released Journal Citation Reports Show Significant Growth of Impact Factors for IOS Press’ Journals

June 30, 2020 - Amsterdam, NL, – IOS Press, an independent international publisher of scientific, technical and medical (STM) journals and books, announces a formidable 40% increase of the Impact Factor of one of its top journals in the field of Neurosciences. The Journal of Parkinson’s Disease now has an Impact Factor of 5.178, according to the 2019 Journal Impact Factor, Journal Citation Reports (Source Clarivate, 2020).* This increase sees the journal move into the first quartile for Neurosciences, ranking it 50 out of 271 in the Web of Science. More...

June 30, 2020

How Upregulation of a Single Gene by SARS-CoV-2 Can Result in a Cytokine Storm

Changes in gene expression suggest possible therapies to prevent and treat COVID-19 based on dexamethasone, calcitriol (vitamin D) and tocopherol (vitamin E) that disrupt the inflammatory “vicious circle” in COVID-19

June 29, 2020 - Amsterdam NL – The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs). Yet it leads to widely diverse clinical symptoms, suggesting multiple pathogenic mechanisms. Writing in Restorative Neurology and Neuroscience, investigators describe how excessive activation of AhRs via the IDO1-kynurenine-AhR signaling pathway, which is used by many pathogens to establish infection, leads to “Systemic AhR Activation Syndrome” (SAAS). The authors also hypothesize that therapies targeting downregulation of AhRs and IDO1 genes should decrease severity of infection. More...

June 29, 2020

Towards FAIR Principles for Research Software

June 24, 2020 - The most viewed article in Data Science in the first half of 2020 focuses on FAIR principles in relation to research software. The position paper analyzes where the existing principles can directly be applied to software, where they need to be adapted or reinterpreted, and where the definition of additional principles is required. Here, we provide extracts from the article intoducing the four foundational FAIR principles in the context of research data. First, a little bit of background. More...

June 24, 2020

Treat Early or Wait? Experts Ponder Best Way to Manage Milder Forms of Spinal Muscular Atrophy

German researchers question 2018 American recommendations regarding when to start treatment in children projected to have less severe disease and recommend early screening and treatment, according to a report published in the Journal of Neuromuscular Diseases

June 11, 2020 - Amsterdam, NL – The advent of therapeutic interventions for spinal muscular atrophy (SMA) has increased the importance of presymptomatic diagnosis and treatment. When to start treatment in children with less severe disease remains controversial. Now, in a report published in the Journal of Neuromuscular Diseases, German researchers argue for an earlier start of treatment to prevent permanent nerve damage, challenging recommendations originally proposed by a group of American experts that suggests a strict follow-up strategy for children expected to have less severe disease. More...

June 11, 2020