Restorative Neurology and Neuroscience

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impact factor 2021 2.406
ISSN print
ISSN online
39; 6 issues
Last issue (39:2) online on 21 May 2021
Next issue
39:3 scheduled for July 2021
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Biochemistry, Medicine & Health, Neurosciences
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COVID-19 Statement – The COVID-19 crisis is affecting many lives, and also research initiatives. We appreciate the efforts of our editors, authors, and reviewers working on our journal at this difficult time. View the full Restorative Neurology and Neuroscience (RNN) COVID-19 statement here.

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Be sure to sign up to the RNN newsletter to receive alerts of new issues and other journal news. Sign up via this link & you can read the latest newsletter here

Latest Content – View all our journal articles here, including the latest special issue (Vol.37, Iss.6) covering the topic: Low Vision.

This interdisciplinary journal publishes papers relating to the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. Experiments on un-anesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind peer review to editorial board members or outside reviewers. Restorative Neurology and Neuroscience is a member of Neuroscience Peer Review Consortium.

Bernhard A. Sabel, PhD
Institute of Medical Psychology
Otto-v.-Guericke University of Magdeburg
Leipzigerstr. 44
39120 Magdeburg, Germany
Tel: +49-391-672 1800
Fax: +49-391-672 1803

Deputy Editor
Andrea Antal
University Göttingen
Göttingen, Germany

Managing Editor
Sylvia Prilloff, PhD

Editorial Assistant
Steffi Matzke

Founding Editor
D.G. Stein

Senior Associate Editors
Doychin N. Angelov
University of Cologne
Cologne, Germany

William Freed
Baltimore, USA

Lutz Jäncke
University Zurich
Zurich, Switzerland

Josef Rauschecker
Georgetown University
Washington, USA

Paolo Maria Rossini
Catholic University of Rome
Rome, Italy

Donald G. Stein
Emory University
Atlanta, USA

Associate Editors
Alessandro Picelli
University of Verona
Verona, Italy

Alexander C.H. Geurts
Donders Centre for Neuroscience, Radboud University Medical Centre
Nijmegen, The Netherlands

Alfredo Gorio
University of Milan
Milano, Italy

Alvaro Pascual-Leone
Beth. Israel Hosp.
Boston, USA

Amir Amedi
The Hebrew University of Jerusalem
Jerusalem, Israel

Amir Hadanny
Shamir Medical Center, Bar Ilan University
Ramat Gan, Israel

Andrea Antal
University Göttingen
Göttingen, Germany

Anthony E. Kline
University of Pittsburgh
Pittsburgh, USA

Antonio Nardone
University of Eastern Piedmont and Fondazione Salvatore Maugeri (IRCCS)
Novara, Italy

Asok Kumar Mukhopadhyay
All India Institute of Medical Sciences
New Delhi, India

Branch Coslett
University of Pennsylvania
Philadelphia, USA

Carmelo Chisari
University Hospital of Pisa
Pisa, Italy

Cathy Stinear
The University of Auckland
Auckland, New Zealand

Cecilia Perin
University of Milan-Bicocca
Milan, Italy

Chandler L. Walker
Indiana University
Indianapolis, USA

Chandramallika Basak
University of Texas at Dallas
Dallas, USA

Chandramouli Krishnan
University of Michigan
Ann Arbor, USA

Chiang-Soon Song
Chosun University
Gwangju, Republic of Korea

Christian Gerloff
University medical Center Hamburg-Eppendorf
Hamburg, Germany

Chuansheng Zhao
China Medical University
Shenyang, China

Clara Casco
University of Padova
Padova, Italy

Edward Taub
CI Therapy Research Group &
Taub Therapy Clinic
Birmingham, USA

Elena Sergeeva
Harvard Medical School
Boston, USA

Elisabetta Ládavas
University of Bologna
Bologna, Italy

Eun Kyoung Kang
Kangwon National University College

Felipe Fregni
Harvard Medical School
Boston, USA

Gabriel de Erausquin
University of Texas Rio Grande
Harlingen, USA

Gary Dunbar
Central Michigan University
Michigan, USA

Giovanni Morone
IRCCS Fondazione Santa Lucia
Roma, Italy

Gitendra Uswatte
University of Alabama at Birmingham
Birmingham, USA

Hongcai Wang
Affiliated Hospital of Binzhou
Binzhou, China

Hugo Théoret
Université de Montréal
Montréal, Canada

Jian-Jia Huang
Chang Gung Memorial Hospital at Linkou
Taoyuan City, Taiwan

Jukka Jolkkonen
University of Eastern Finland
Kuopio, Finland

Associate Editors (contd..)
Jae-Young Han
Chonnam National University
Gwangju, Republic of Korea

Julio J. Ramirez
Davidson College
Davidson, USA

Karem H. Alzoubi
Jordan University of Science and Technology
Irbid, Jordan

Kwok-Fai So
University of Hong Kong
Hong Kong, China

Lara Boyd
University of British Columbia
Vancouver, Canada

Lechoslaw Turski
German Center for Neurodegenerative Diseases
Bonn, Germany

Leonardo Cohen
Bethesda, USA

Li He
Sichuan University
Sichuan, China

Lofti Merabet
Massachusetts Eye and Ear Harvard Medical School
Boston, USA

Luca Battaglini
University of Padova
Padova, Italy

Martin Lotze
University Medicine Greifswald
Greifswald, Germany

Mattias K. Sköld
Karolinska Institutet
Stockholm & Uppsala University
Stockholm, Sweden

Mei Zhao
China Medical University
Shenyang City, China

Michael Borich
University of British Columbia
Vancouver, Canada

Michihiro Osumi
Kio University
Nara, Japan

Mircea Ariel Schoenfeld
Kliniken Schmieder Heidelberg
Heidelberg, Germany

Niklas Marklund
Lund University
Lund, Sweden

Paco Herson
Oregon Health and Science University
Portland, USA

Pei-Hsin Liu
Tzu Chi University
Hualien, Taiwan

Peter A. Tass
Stanford University
Stanford, USA

Ragab K. Elnaggar
Cairo University
Giza, Egypt

Randolph Nudo
University Kansas
Kansas City, USA

Randolph Nudo
University Kansas
Kansas City, USA

Reinhard Werth
Ludwig-Maximilians-University of Munich
Munich, Germany

Rima Dada
All India Institute of Medical Sciences
New Delhi, India

Robert W. Regenhardt
Massachusetts General Hospital
Boston, USA

Rocco Salvatore Calabrò
IRCCS Centro Neurolesi Bonino-Pulejo
Messina, Italy

Roy Hamilton
University of Pennsylvania
Philadelphia, USA

Seth Finklestein
Biotrofix Inc.
Nedham, USA

Shamali Dusane
University of Illinois at Chicago
Chicago, USA

Shelly Levy-Tzedek
Hebrew University in Jerusalem
Jerusalem, Israel

Si-nae Ahn
Cheongju University
Cheongju-si, Republic of Korea

Solon Thanos
University of Münster
Münster, Germany

Song Liu
Capital Medical University
Beijing, China

Souichi Ohta
Kyoto University
Kyoto, Japan

Stephen Waxman
Yale University School of Medicine
New Haven, USA

Steven L. Wolf
Emory University
Atlanta, USA

Sung-Bom Pyun
Korea University College of Medicine
Seoul, Korea

Sylvie Chokron
Université Paris-Descartes and CNRS
Paris, France

Tanuj Dada
All India Institute of Medical Sciences
New Delhi, India

Teri Lawton
Early Childhood Parenting Institute
Encinitas, USA

Thomas Platz
Ernst-Moritz-Arndt University
Greifswald, Germany

Trisha Kesar
Emory University
Atlanta, USA

Uri Polat
Tel Aviv University
Ramat Aviv, Israel

Xavier E. Ndone-Ekane
University of Eastern Finland
Kuopio, Finland

Xavier Navarro
University Barcelona
Barcelona, Spain

Yong Hu
The University of Hong Kong
Hong Kong, China

Youngkeun Woo
Jeonju University
Jeonju, Republic of Korea

Yun-Hee Kim
Sungkyunkwan University School of Medicine
Seoul, Republic of Korea




When an article is accepted for publication, authors are required to pay a publication fee of EUR580/US$700. Details of payment will be given at the article’s acceptance. 


In addition to the publication fee, authors have the option to make their article freely available on the Publisher's journal platform. For a charge of EUR1250/US$1450 your article (including pre-publication) will be freely accessible immediately upon publication. A form to request open access will be supplied with the acceptance letter. 

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By submitting my article to this journal, I agree to the Author Copyright Agreement, the IOS Press Ethics Policy, and the IOS Press Privacy Policy.

Submission of an article is understood to imply that the article is original and unpublished and is not being considered for publication elsewhere. Any possible conflict of interest, financial or otherwise, related to the submitted work must be clearly indicated in the manuscript.

The article type (Research paper, Review paper, Editorial, Case Report, Letter to the Editor, etc) should be clearly mentioned in the cover letter to help the editorial process.

This journal operates with single-blind peer review. If the author prefers double-blind peer review, then please submit the manuscript excluding the author listing and make sure the document is anonymized, and list the authors and affiliations only in the cover letter for the Editor.

Resubmissions should include the manuscript number in the cover letter. The author's replies to the reviewer comments should be included within the revised manuscript itself (at the top). The revised paper should always be a Word document.

Authors are requested to submit their manuscript electronically to Note that the manuscript should be uploaded as one file with tables and figures included. This file can be a Word document, a PDF, or an embedded or zip file (.rar) if separate high-resolution figures or a supplemental file such as a video are also to be included with the submission (the file size maximum for a video is 25MB). If the video is too large to submit, please contact to arrange a file transfer. For further information about submitting supplementary data see “Supplementary Data.”

All correspondence concerning editorial matters as well as information regarding submissions should be sent to: Editor-in-Chief: Bernhard A. Sabel, PhD Institute of Medical Psychology Otto-v.-Guericke University of Magdeburg Leipzigerstr. 44 39120 Magdeburg Germany Tel. +49 391 672 1800 Fax +49 391 672 1803 Email: Editorial Assistant: Steffi Matzke


Procedures involving experiments on human subjects should be in accord with the ethical standards of the Committee on Human Experimentation of the institution in which the experiments were done or in accord with the Helsinki Declaration of 1975. The author must state compliance in the cover letter and in the Methods section of the article.

Procedures involving experimentation on animal subjects should be in accord with either the guide of the institution in which the experiments were done, or with the National Research Council’s guide for the care and use of laboratory animals. The author must state compliance in the cover letter and in the Methods section of the article.

Preferably patients in figures should be unrecognizable. Authors are responsible for obtaining patient permission for use of the material from all recognizable participants in photographs, videos, or other information that may be published in the Journal or on the journal’s website. A statement that permission was granted by the patient must accompany the figure legend. Do not use study participants' names, initials, or hospital numbers anywhere in the manuscript (including figures).


Organization of the paper and style of presentation
Manuscripts must be written in English. Authors whose native language is not English are recommended to seek the advice of a native English speaker, if possible, before submitting their manuscripts. You can also visit Peerwith. Peerwith offers a language and copyediting service to all scientists who want to publish their manuscript in scientific peer-reviewed periodicals and books. Manuscripts should be prepared with wide margins and double spacing throughout, including the abstract, footnotes and references. Every page of the manuscript, including the title page, references, tables, etc., should be numbered. However, in the text no reference should be made to page numbers; if necessary, one may refer to sections. Try to avoid the excessive use of italics and bold face. Manuscripts should be organized in the following order:

  • Title page including Abtract and Keywords
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Headings and subheadings should be numbered and typed on a separate line, without indentation. SI units should be used, i.e., the units based on the metre, kilogramme, second, etc.

Title page

  • Title (should be clear, descriptive and concise).
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Changes in Authorship
When submitting the manuscript the author listing and order should be final. If any addition, deletion or rearrangement of author names in the authorship list does need to be made after submission, this can be done only before acceptance and with the Editor’s approval. To request such a change, the Editor must receive the following from the corresponding author: (1) the reason for the change in author list and (2) written confirmation from all authors, including the affected author, that they agree with the addition, removal or rearrangement.

Only in exceptional circumstances will the Editor consider the addition, deletion or rearrangement of authors after the manuscript has been accepted. While the Editor considers the request, publication of the manuscript will be suspended. If the manuscript has already been published in an issue, any requests approved by the Editor will result in an Erratum.

Authors are requested to use the APA (American Psychological Association) citation style. APA in-text citations should include the author's last name followed by the year of publication. All publications cited in the text should be presented in an alphabetical list of references at the end of the manuscript. Submitted articles can be listed as (author(s), unpublished data). See their website for more information. Authors are responsible for checking the accuracy of all references. Manuscripts will not be considered if they do not conform to the APA citation guidelines.

References must be listed alphabetically in APA style:
Amengual, J. L., Rojo, N., Veciana De Las Heras, M., Marco-Pallarés, J., Grau-Sánchez, J., Schneider, S., ... & Rodríguez-Fornells, A. (2013). Sensorimotor plasticity after music-supported therapy in chronic stroke patients revealed by transcranial magnetic stimulation. PLoS One, 8(4), e61883.
Anderson, A. K. (2005). Affective influences on the attentional dynamics supporting awareness. Journal of Experimental Psychology: General, 154, 258–281.
Anderson, A. K., Christoff, K., Panitz, D., De Rosa, E., & Gabrieli, J. D. E. (2003). Neural correlates of the automatic processing of threat facial signals. Journal of Neuroscience, 23, 5627–5633.
Armony, J. L., & Dolan, R. J. (2002). Modulation of spatial attention by fear-conditioned stimuli: An event-related fMRI study. Neuropsychologia, 40, 817–826.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56,893–897.
Calvo, M. G., & Lang, P. J. (2004). Gaze patterns when looking at emotional pictures: Motivationally biased attention. Motivation and Emotion, 28, 221–243.
Carretie, L., Hinojosa, J. A., Martin-Loeches, M., Mecado, F., & Tapia, M. (2004). Automatic attention to emotional stimuli: Neural correlates. Human Brain Mapping, 22, 290–299.

Footnotes should only be used if absolutely essential. In most cases it is possible to incorporate the information in the text. If used, they should be numbered in the text, indicated by superscript numbers and kept as short as possible.

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Colour figures
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Supplementary Material
Supplementary material can be submitted with the manuscript, included within the manuscript after the Figures and Tables (or otherwise after the References). Each supplementary item should have a legend and should not exceed the file size of 10MB. Supplemental videos can be submitted separately (see top of page for submission guidelines of videos). A short description of the supplementary items should be included under the header of “Supplementary Material” within the manuscript before the “References”. Supplementary material will be made available in the format in which it was provided. Large datasets should be hosted on the author’s own or institute’s website or in an appropriate database, and should be properly cited within the manuscript.


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Quoting from other publications
An author, when quoting from someone else's work or when considering reproducing figures or table from a book or journal article, should make sure that he is not infringing a copyright. Although in general an author may quote from other published works, he should obtain permission from the holder of the copyright if he wishes to make substantial extracts or to reproduce tables, plates or other figures. If the copyright holder is not the author of the quoted or reproduced material, it is recommended that the permission of the author should also be sought. Material in unpublished letters and manuscripts is also protected and must not be published unless permission has been obtained. Submission of a paper will be interpreted as a statement that the author has obtained all the necessary permission. A suitable acknowledgement of any borrowed material must always be made.

Quoting from Restorative Neurology and Neuroscience
Permissions for use of materials published in RNN Reports (figures, tables, thesis publication) can be requested at


Restorative Neurology and Neuroscience operates a rigorous, timely, blinded peer review process (with an option for double-blind if requested) by experts in the field. Manuscripts submitted to the Restorative Neurology and Neuroscience will be assessed for suitability for publication in the journal by the Editor-in-Chief. Manuscripts that are deemed unsuitable may be rejected without peer review by the Editor-in-Chief and/or the Associate Editors, and the author will be informed as soon as possible.

Manuscripts that are deemed suitable for peer review are assigned to appropriate anonymous referees (a minimum of two) for confidential review. Referee reports are then assessed by the the Editor-in-Chief. Once approved this decision is then conveyed to the author along with the referees’ anonymized reports.

The initial decision will be one of the following: rejection, acceptance without revision, or potentially acceptable after minor or major revisions. Revised manuscripts will be appraised by the Editor-in-Chief, who may seek the opinion of referees (prior or new) before making a decision. This decision is then conveyed to the author along with the anonymized referees’ reports. Once accepted, manuscripts are normally published on-line without delay and appear in the next available print issue (published quarterly).

The Editor-in-Chief has ultimate responsibility for what is published in the journal. Authors may appeal decisions by contacting the Editor-in-Chief (at Authors will be informed in writing of the result of their appeal.


Accepted articles will be placed online as "pre-press" articles two weeks after acceptance. The corresponding author will receive the PDF proof around the same time, and is asked to check this proof carefully (the publisher will execute a cursory check only). Corrections other than printer's errors should be avoided. Costs arising from excessive corrections will be charged to the authors. The pre-press file will remain as the uncorrected proof version until the article is published in an issue and the final published version replaces the pre-press file.


A growing number of funding agencies now require that research articles they have funded must be made open access. This may be either by mandating deposit in repositories after an embargo period or by stipulating that research is published as open access. Publishing in this journal complies with all major funding agency requirements.


Complimentary copy
The corresponding author of a contribution to the journal is entitled to receive 1 author’s copy of the pdf free of charge, unless otherwise stated. Free copies will not be provided for conference proceedings and abstract issues.

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An order form for reprints, additional journal copies or a non-watermarked pdf file will be provided along with the pdf proof. If you wish to order reprints of an earlier published article, please contact the publisher for a quotation. IOS Press, Fax: +31 20 6870039. Email: An author is entitled to 25 % discount on IOS Press books. See Author's Discount (25%) on all IOS Press book publications.

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How Upregulation of a Single Gene by SARS-CoV-2 Can Result in a Cytokine Storm

29 Jun 2020 - Amsterdam NL – The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs). Yet it leads to widely diverse clinical symptoms, suggesting multiple pathogenic mechanisms. Writing in Restorative Neurology and Neuroscience, investigators describe how excessive activation of AhRs via the IDO1-kynurenine-AhR signaling pathway, which is used by many pathogens to establish infection, leads to “Systemic AhR Activation Syndrome” (SAAS). The authors also hypothesize that therapies targeting downregulation of AhRs and IDO1 genes should decrease severity of infection....

Light at the End of the Tunnel for Most Individuals With Low-Vision

22 Jan 2020 - Amsterdam, NL – Progress in research and technology is giving rise to an optimistic future for compensation and restoration of low vision, according to research in a special issue of Restorative Neurology and Neuroscience, published by IOS Press. Seven studies explore different aspects of vision loss after damage to the retina, optic nerve or brain due to diseases such as glaucoma or optic neuropathy. Remarkable progress is being made to treat conditions of partial blindness that have previously been considered irreversible. ...

Hearing Through Your Fingers: Device that Converts Speech to Touch Enables the Hearing-Impaired to Hear Through Their Fingertips

03 Jun 2019 - Amsterdam, NL – A novel study published in Restorative Neurology and Neuroscience provides the first evidence that a simple and inexpensive non-invasive speech-to-touch sensory substitution device has the potential to improve hearing in hearing-impaired cochlear implant patients, as well as individuals with normal hearing, to better discern speech in various situations like learning a second language or trying to deal with the "cocktail party effect." The device can provide immediate multisensory enhancement without any training....

Yoga Regimen Reduces Severity of Rheumatoid Arthritis Symptoms, Alleviates Depression, and Improves Patient Quality of Life

05 Feb 2019 - Amsterdam, NL – According a study published in Restorative Neurology and Neuroscience, eight weeks of intensive yoga practice significantly decreases the severity of physical and psychological symptoms in patients with active rheumatoid arthritis (RA), a debilitating chronic auto-immune inflammatory disease. Marked improvements were seen in the levels of certain inflammatory biomarkers and assessments of functional status and disease activity in patients studied, demonstrating yoga’s promotive, preventive, curative, and rehabilitative potential for achieving optimal health....

Genre May Impact Cognitive Training Using Video Games

02 Oct 2017 - Amsterdam, NL – Video games are quickly becoming a hot topic in cognitive training. Many see them as a potential tool to help patients improve their performance and memory, yet little is known about how different types of video games may affect white matter in the brain and cognition....

Training Can Improve Athletes’ Stereo Vision

05 Jul 2017 - Amsterdam, NL – Stereo vision allows individuals to perceive depth differences in their surroundings. Important to pedestrians and drivers, for example, depth perception plays a key role in many sporting activities. If the ability to accurately determine the distance and speed of a fast-moving object can be improved, athletes have the potential to improve their performance. In a new study published in Restorative Neurology and Neuroscience, researchers found that by training athletes using repetitive stereoscopic stimuli, their reaction speed to those stimuli could be significantly improved....

Brain Stimulation Protocol Reduces Spasticity in Spinal Cord Injury Patients

19 Jun 2017 - Amsterdam, NL – Spasticity, uncontrolled muscle contractions, is a common disorder experienced by patients with spinal cord injuries (SCI). Previous studies have shown that excitatory repetitive transcranial magnetic stimulation (rTMS) can reduce spasticity. In a new study published in Restorative Neurology and Neuroscience, researchers found that a protocol of rTMS, excitatory intermittent theta burst stimulation (iTBS), was successful in reducing spasticity in patients with SCI and therefore may be a promising therapeutic tool....

2017 Neuroscience & Neurology brochure available

06 Jun 2017 - IOS Press Neuroscience & Neurology brochure...

Inosine Treatment Helps Recovery of Motor Functions after Brain Injury

03 Aug 2016 - Brain tissue can die as the result of stroke, traumatic brain injury, or neurodegenerative disease. When the affected area includes the motor cortex, impairment of the fine motor control of the hand can result. In a new study published in Restorative Neurology and Neuroscience, researchers found that inosine, a naturally occurring purine nucleoside that is released by cells in response to metabolic stress, can help to restore motor control after brain injury....

New Neuroscience & Neurology Brochure Available

01 Apr 2016 - Journals and Books...

Mentally Challenging Activities Key to a Healthy Aging Mind

15 Jan 2016 - One of the greatest challenges associated with the growing numbers of aged adults is how to maintain a healthy aging mind. Taking up a new mental challenge such as digital photography or quilting may help maintain cognitive vitality, say researchers reporting in Restorative Neurology and Neuroscience. ...

New Tool May Help Predict Patients’ Motor Function Recovery After Stroke

14 Jan 2016 - Graph theoretical analysis is proving to be helpful in understanding complex networks in the brain. Investigators in the Republic of Korea used a graph theoretical approach in examining the changes in the configuration of the two hemispheres of the brain in 12 patients after stroke. They found it helped understand the dynamic reorganization of both hemispheric networks in the brain and to predict recovery of motor function. Their findings are published in Restorative Neurology and Neuroscience....

Magnetic Stimulation Effective in Helping Parkinson’s Patients Walk

01 Sep 2015 - About 50% of patients with Parkinson’s disease (PD) experience freezing of gait (FOG), an inability to move forward while walking. This can affect not only mobility but also balance. In a new study published in Restorative Neurology and Neuroscience, researchers report that repetitive transcranial magnetic stimulation (rTMS) can reduce FOG and improve other motor skills in PD patients....

Mental Visual Imaging Training Improves Multiple Sclerosis Patients’ Well-Being

27 Aug 2015 - Patients with relapsing-remitting multiple sclerosis (RR-MS), the most common form of the disease, often have deficits in two neuropsychological functions, autobiographical memory (AM) and episodic future thinking (EFT), which impact quality of life. In a new study published in Restorative Neurology and Neuroscience, researchers report that training RR-MS patients in mental visual imagery (MVI) can improve AM/EFT functioning....

New Study Indicates Magnetic Stimulation Effective in Reducing Bedwetting

25 Aug 2015 - Bedwetting, or nocturnal enuresis, causes distress in children and young adults, as well as for their parents or caregivers. The causes are not fully understood and there may be both physiological and psychological components to the condition. In a new study published in Restorative Neurology and Neuroscience, researchers report that repetitive sacral root magnetic stimulation (rSMS) can reduce the frequency of nighttime bedwetting and improve quality-of-life for sufferers....

Researchers Develop New Technique for Modeling Neuronal Connectivity Using Stem Cells

17 Jun 2015 - Human stem cells can be differentiated to produce other cell types, such as organ cells, skin cells, or brain cells. While organ cells, for example, can function in isolation, brain cells require synapses, or connectors, between cells and between regions of the brain. In a new study published in Restorative Neurology and Neuroscience, researchers report successfully growing multiple brain structures and forming connections between them in vitro, in a single culture vessel, for the first time....

Patient Awakes from Post-Traumatic Minimally Conscious State after Administration of Depressant Drug

16 Dec 2014 - A patient who had suffered a traumatic brain injury unexpectedly recovered full consciousness after the administration of midazolam, a mild depressant drug of the GABA A agonists family. This resulted in the first recorded case of an “awakening” from a minimally-conscious state (MCS) using this therapy. Although similar awakenings have been reported using other drugs, this dramatic result was unanticipated. It is reported in Restorative Neurology and Neuroscience. ...

User-Friendly Electronic “EyeCane” Enhances Navigational Abilities for the Blind

21 Oct 2014 - White Canes provide low-tech assistance to the visually impaired, but some blind people object to their use because they are cumbersome, fail to detect elevated obstacles, or require long training periods to master. Electronic travel aids (ETAs) have the potential to improve navigation for the blind, but early versions had disadvantages that limited widespread adoption. A new ETA, the “EyeCane,” developed by a team of researchers at The Hebrew University of Jerusalem, expands the world of its users, allowing them to better estimate distance, navigate their environment, and avoid obstacles, according to a new study published in Restorative Neurology and Neuroscience. ...

EyeMusic Sensory Substitution Device Enables the Blind to “See” Colors and Shapes

05 Feb 2014 - Using auditory or tactile stimulation, Sensory Substitution Devices (SSDs) provide representations of visual information and can help the blind “see” colors and shapes. SSDs scan images and transform the information into audio or touch signals that users are trained to understand, enabling them to recognize the image without seeing it....

2014 Neuroscience Neurology Brochure

31 Jan 2014 - Download the 2014 Neuroscience Neurology Brochure here. ...

Real-Time Video Feedback Could Improve Effect of Core Stabilization Exercise in Stroke Patients

31 Jan 2014 - About 80% of stroke survivors experience hemiparesis, which causes weakness or the inability to move one side of the body. Core stabilization exercise to improve postural stability and independent walking in chronic hemiparetic stroke patients could be enhanced by real-time video feedback, report researchers in Restorative Neurology and Neuroscience....

Residual Activity “Hot Spots” in the Brain Key for Vision Recovery in Stroke Patients

03 Jan 2014 - Scientists know that vision restoration training (VRT) can help patients who have lost part of their vision due to glaucoma, optic nerve damage, or stroke regain some of their lost visual functions, but they do not understand what factors determine how much visual recovery is achieved. ...

Corticosteroid Added to Standard Treatment Improves Eyesight in Patients with Sudden Vision Loss

20 Nov 2013 - Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the leading causes of sudden and irreversible loss of vision in older adults. In a prospective randomized trial of 60 patients with NAION, investigators have shown that the addition of the corticosteroid fluocortolone (FC) to standard therapy significantly improves both short- and long-term visual acuity, especially when given soon after the onset of symptoms. Their results are published in Restorative Neurology and Neuroscience....

Transcranial Direct Current Stimulation Improves Sleep in Patients with Post-Polio Syndrome

27 Aug 2013 - Of the 15 million people around the world who have survived poliomyelitis, up to 80% report progressive deteriorating strength and endurance many years after infection, a condition known as post-polio syndrome (PPS). Researchers in Italy from the National Hospital for Poliomyelitis, the Policlinico G.B. De Rossi in Verona, and the University of Milan have found that transcranial direct current stimulation (tDCS) for 15 days improved sleep and fatigue symptoms in patients with PPS, suggesting this non-invasive tool may be a new therapeutic option for this condition. Their results are published in Restorative Neurology and Neuroscience....

New Study Supports Intracerebral Injections of Bone Marrow-Derived Stem Cells to Prevent or Reduce Post-Stroke Cognitive Deficits

26 Aug 2013 - Cognitive deficits following ischemic stroke are common and debilitating, even in the relatively few patients who are treated expeditiously so that clots are removed or dissolved rapidly and cerebral blood flow restored. A new study in Restorative Neurology and Neuroscience demonstrates that intracerebral injection of bone-marrow-derived mesenchymal stem cells (BSCs) reduces cognitive deficits produced by temporary occlusion of cerebral blood vessels in a rat model of stroke, suggesting that BSCs may offer a new approach for reducing post-stroke cognitive dysfunction. ...

Novel Chinese Herbal Medicine JSK Improves Spinal Cord Injury Outcomes in Rats

20 Aug 2013 - A new study published in Restorative Neurology and Neuroscience demonstrates that Chinese herbal medicine Ji-Sui-Kang (JSK), given systemically for three weeks after injury in rats, improved locomotor function, reduced tissue damage, and preserved the structure of neural cells compared to control rats. The report also includes data showing that JSK may first act to reduce inflammation and cell apoptosis and death, and boost local oxygen supply while, later on, it appears to restore function and promote tissue regeneration. ...

Necrostatin-1 Counteracts Aluminum’s Neurotoxic Effects

05 Aug 2013 - Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer’s disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum’s neurotoxic effects....

Higher Education May Be Protective Against MS-Associated Cognitive Deficits

03 Jul 2013 - Multiple sclerosis (MS) can lead to severe cognitive impairment as the disease progresses. Researchers in Italy have found that patients with high educational levels show less impairment on a neuropsychological evaluation compared with those with low educational levels. Their results are published in Restorative Neurology and Neuroscience....

Short-Term Benefits Seen With Repetitive Transcranial Magnetic Stimulation for Focal Hand Dystonia

10 Apr 2013 - Repetitive transcranial magnetic stimulation (rTMS) is being increasingly explored as a therapeutic tool for movement disorders associated with deficient inhibition throughout the central nervous system. This includes treatment of focal hand dystonia (FHD), characterized by involuntary movement of the fingers either curling into the palm or extending outward. A new study published in Restorative Neurology and Neuroscience reports short-term changes in behavioral, physiologic, and clinical measures that support further research into the therapeutic potential of rTMS....

Shift of Language Function to Right Hemisphere Impedes Post-Stroke Aphasia Recovery

04 Apr 2013 - In a study designed to differentiate why some stroke patients recover from aphasia and others do not, investigators have found that a compensatory reorganization of language function to right hemispheric brain regions bodes poorly for language recovery. Patients who recovered from aphasia showed a return to normal left-hemispheric language activation patterns. These results, which may open up new rehabilitation strategies, are available in the current issue of Restorative Neurology and Neuroscience....

Shedding Light on Early Parkinson’s Disease Pathology

02 Apr 2013 - In a mouse model of early Parkinson’s disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the substantia nigra (SN), without the loss of nigral dopaminergic neurons. These findings, which may cast light on the molecular processes involved in the initial stages of PD, are available in the current issue of Restorative Neurology and Neuroscience....

Novel Herbal Compound Offers Potential to Prevent and Treat Alzheimer’s Disease

19 Feb 2013 - Administration of the active compound tetrahydroxystilbene glucoside (TSG) derived from the Chinese herbal medicine Polygonum multiflorum Thunb, reversed both overexpression of α-synuclein, a small protein found in the brain, and its accumulation using a mouse model of Alzheimer’s disease. These results, which may shed light on the neuropathology of AD and open up new avenues of treatment, are available in the current issue of Restorative Neurology and Neuroscience....

2013 Neuroscience Neurology Brochure

27 Nov 2012 - Download the 2013 Neuroscience Neurology Brochure here. ...

Abnormal Involuntary Eye Movements in the “Lazy Eye” Disease Amblyopia Linked to Changes in Subcortical Regions of the Brain

17 Oct 2012 - The neural mechanism underlying amblyopia, also called “lazy eye” is still not completely clear. A new study now reports abnormal eye movements of the lazy eye, which suggests that disturbed functioning of eye movement coordination between both eyes and not primarily the dysfunction of the visual cortex may be a cause of amblyopia (Xue-feng Shi et al.)....

Neural Interface for Hand Prosthesis Can Restore Function in Brain Areas Responsible for Motor Control

21 Aug 2012 - Amputation disrupts not only the peripheral nervous system but also central structures of the brain. While the brain is able to adapt and compensate for injury in certain conditions, in amputees the traumatic event prevents adaptive cortical changes. A group of scientists reports adaptive plastic changes in an amputee’s brain following implantation of multielectrode arrays inside peripheral nerves. Their results are available in the current issue of Restorative Neurology and Neuroscience. ...

Scientists Report Promising New Direction for Cognitive Rehabilitation in the Elderly

21 Aug 2012 - Research has found that declines in temporal information processing (TIP), the rate at which auditory information is processed, underlies the progressive loss of function across multiple cognitive systems in the elderly, including new learning, memory, perception, attention, thinking, motor control, problem solving, and concept formation. In a new study, scientists have found that elderly subjects who underwent temporal training improved not only the rate at which they processed auditory information, but also in other cognitive areas. The study is published in the current issue of Restorative Neurology and Neuroscience. ...

Therapy Combining Exercise and Neuroprotective Agent Shows Promise for Stroke Victims

16 Aug 2012 - In a study published in the current issue of Restorative Neurology and Neuroscience scientists report that a therapy combining exercise with the neurovascular protective agent S-nitrosoglutathione (GSNO) improved recovery from stroke in a rat model. GSNO is a compound found naturally in the body and it has no known side effects or toxicity. ...

Music to My Eyes: Device Converting Images into Music Helps Individuals without Vision Reach for Objects in Space

09 Jul 2012 - Sensory substitution devices (SSDs) use sound or touch to help the visually impaired perceive the visual scene surrounding them. The ideal SSD would assist not only in sensing the environment but also in performing daily activities based on this input. For example, accurately reaching for a coffee cup, or shaking a friend’s hand. In a new study, scientists trained blindfolded sighted participants to perform fast and accurate movements using a new SSD, called EyeMusic. Their results are published in the July issue of Restorative Neurology and Neuroscience....

Electrical Brain Stimulation Can Alleviate Swallowing Disorders after Stroke

02 Jul 2012 - After stroke, patients often suffer from dysphagia, a swallowing disorder that results in greater healthcare costs and higher rates of complications such as dehydration, malnutrition, and pneumonia. In a new study published in the July issue of Restorative Neurology and Neuroscience, researchers have found that transcranial direct current stimulation (tDCS), which applies weak electrical currents to the affected area of the brain, can enhance the outcome of swallowing therapy for post-stroke dysphagia. ...

Device Implanted in Brain Has Therapeutic Potential for Huntington’s Disease

19 Jun 2012 - Studies suggest that neurotrophic factors, which play a role in the development and survival of neurons, have significant therapeutic and restorative potential for neurologic diseases such as Huntington’s disease. However, clinical applications are limited because these proteins cannot easily cross the blood brain barrier, have a short half-life, and cause serious side effects. Now, a group of scientists has successfully treated neurological symptoms in laboratory rats by implanting a device to deliver a genetically engineered neurotrophic factor directly to the brain. They report on their results in the latest issue of Restorative Neurology and Neuroscience. ...

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