Restorative Neurology and Neuroscience
This interdisciplinary journal publishes papers relating to the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. Experiments on un-anesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind peer review to editorial board members or outside reviewers. Restorative Neurology and Neuroscience is a member of Neuroscience Peer Review Consortium.
Paolo Maria Rossini
Donald G. Stein
Alexander C.H. Geurts
Anthony E. Kline
Asok Kumar Mukhopadhyay
Chandler L. Walker
Eun Kyoung Kang
Gabriel de Erausquin
Associate Editors (contd..)
Julio J. Ramirez
Karem H. Alzoubi
Mattias K. Sköld
Mircea Ariel Schoenfeld
Peter A. Tass
Ragab K. Elnaggar
Robert W. Regenhardt
Rocco Salvatore Calabrò
Steven L. Wolf
Xavier E. Ndone-Ekane
PLEASE SUBMIT YOUR MANUSCRIPT HERE.
When an article is accepted for publication, authors are required to pay a publication fee of EUR580/US$700. Details of payment will be given at the article’s acceptance.
OPEN ACCESS OPTION
In addition to the publication fee, authors have the option to make their article freely available on the Publisher's journal platform. For a charge of EUR1250/US$1450 your article (including pre-publication) will be freely accessible immediately upon publication. A form to request Open Access will be supplied with the acceptance letter.
Click here to discover about the IOS Press Open Library, the types of Open Access and funder’s mandates, and also to check if there are any institutional agreements that you might be eligible for.
Manuscripts that do not adhere to the following instructions will be returned to the corresponding author for technical revision before undergoing peer review.
Submission of an article is understood to imply that the article is original and unpublished and is not being considered for publication elsewhere. Any possible conflict of interest, financial or otherwise, related to the submitted work must be clearly indicated in the manuscript.
The article type (Research paper, Review paper, Editorial, Case Report, Letter to the Editor, etc) should be clearly mentioned in the cover letter to help the editorial process.
This journal operates with single-blind peer review. If the author prefers double-blind peer review, then please submit the manuscript excluding the author listing and make sure the document is anonymized, and list the authors and affiliations only in the cover letter for the Editor.
Resubmissions should include the manuscript number in the cover letter. The author's replies to the reviewer comments should be included within the revised manuscript itself (at the top). The revised paper should always be a Word document.
Authors are requested to submit their manuscript electronically to www.mstracker.com. Note that the manuscript should be uploaded as one file with tables and figures included. This file can be a Word document, a PDF, or an embedded or zip file (.rar) if separate high-resolution figures or a supplemental file such as a video are also to be included with the submission (the file size maximum for a video is 25MB). If the video is too large to submit, please contact firstname.lastname@example.org to arrange a file transfer. For further information about submitting supplementary data see “Supplementary Data.”
All correspondence concerning editorial matters as well as information regarding submissions should be sent to: Editor-in-Chief: Bernhard A. Sabel, PhD Institute of Medical Psychology Otto-v.-Guericke University of Magdeburg Leipzigerstr. 44 39120 Magdeburg Germany Tel. +49 391 672 1800 Fax +49 391 672 1803 Email: email@example.com Editorial Assistant: Steffi Matzke
ETHICS POLICIES AND PATIENT PERMISSIONS
Procedures involving experiments on human subjects should be in accord with the ethical standards of the Committee on Human Experimentation of the institution in which the experiments were done or in accord with the Helsinki Declaration of 1975. The author must state compliance in the cover letter and in the Methods section of the article.
Procedures involving experimentation on animal subjects should be in accord with either the guide of the institution in which the experiments were done, or with the National Research Council’s guide for the care and use of laboratory animals. The author must state compliance in the cover letter and in the Methods section of the article.
Preferably patients in figures should be unrecognizable. Authors are responsible for obtaining patient permission for use of the material from all recognizable participants in photographs, videos, or other information that may be published in the Journal or on the journal’s website. A statement that permission was granted by the patient must accompany the figure legend. Do not use study participants' names, initials, or hospital numbers anywhere in the manuscript (including figures).
PREPARATION OF MANUSCRIPTS
Organization of the paper and style of presentation
Manuscripts must be written in English. Authors whose native language is not English are recommended to seek the advice of a native English speaker, if possible, before submitting their manuscripts. You can also visit Peerwith. Peerwith offers a language and copyediting service to all scientists who want to publish their manuscript in scientific peer-reviewed periodicals and books. Manuscripts should be prepared with wide margins and double spacing throughout, including the abstract, footnotes and references. Every page of the manuscript, including the title page, references, tables, etc., should be numbered. However, in the text no reference should be made to page numbers; if necessary, one may refer to sections. Try to avoid the excessive use of italics and bold face. Manuscripts should be organized in the following order:
- Title page including Abtract and Keywords
- Body of text (divided by subheadings)
- Figure captions
Headings and subheadings should be numbered and typed on a separate line, without indentation. SI units should be used, i.e., the units based on the metre, kilogramme, second, etc.
- Title (should be clear, descriptive and concise).
- Full name(s) of author(s), with each author's last name in CAPITAL LETTERS. Please indicate who is the corresponding author. Full affiliation(s). Delineate affiliations with lowercase letters. Present address of author(s), if different from affiliation. Running title (45 characters or less, including spaces). Complete address of corresponding author, including telephone number and email address * Leave the author information blank if double-blind peer review is wished for, but do include the information in the cover letter.
Changes in Authorship
When submitting the manuscript the author listing and order should be final. If any addition, deletion or rearrangement of author names in the authorship list does need to be made after submission, this can be done only before acceptance and with the Editor’s approval. To request such a change, the Editor must receive the following from the corresponding author: (1) the reason for the change in author list and (2) written confirmation from all authors, including the affected author, that they agree with the addition, removal or rearrangement.
Only in exceptional circumstances will the Editor consider the addition, deletion or rearrangement of authors after the manuscript has been accepted. While the Editor considers the request, publication of the manuscript will be suspended. If the manuscript has already been published in an issue, any requests approved by the Editor will result in an Erratum.
Authors are requested to use the APA (American Psychological Association) citation style. APA in-text citations should include the author's last name followed by the year of publication. All publications cited in the text should be presented in an alphabetical list of references at the end of the manuscript. Submitted articles can be listed as (author(s), unpublished data). See their website for more information. Authors are responsible for checking the accuracy of all references. Manuscripts will not be considered if they do not conform to the APA citation guidelines.
References must be listed alphabetically in APA style:
Amengual, J. L., Rojo, N., Veciana De Las Heras, M., Marco-Pallarés, J., Grau-Sánchez, J., Schneider, S., ... & Rodríguez-Fornells, A. (2013). Sensorimotor plasticity after music-supported therapy in chronic stroke patients revealed by transcranial magnetic stimulation. PLoS One, 8(4), e61883.
Anderson, A. K. (2005). Affective influences on the attentional dynamics supporting awareness. Journal of Experimental Psychology: General, 154, 258–281.
Anderson, A. K., Christoff, K., Panitz, D., De Rosa, E., & Gabrieli, J. D. E. (2003). Neural correlates of the automatic processing of threat facial signals. Journal of Neuroscience, 23, 5627–5633.
Armony, J. L., & Dolan, R. J. (2002). Modulation of spatial attention by fear-conditioned stimuli: An event-related fMRI study. Neuropsychologia, 40, 817–826.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56,893–897.
Calvo, M. G., & Lang, P. J. (2004). Gaze patterns when looking at emotional pictures: Motivationally biased attention. Motivation and Emotion, 28, 221–243.
Carretie, L., Hinojosa, J. A., Martin-Loeches, M., Mecado, F., & Tapia, M. (2004). Automatic attention to emotional stimuli: Neural correlates. Human Brain Mapping, 22, 290–299.
Footnotes should only be used if absolutely essential. In most cases it is possible to incorporate the information in the text. If used, they should be numbered in the text, indicated by superscript numbers and kept as short as possible.
Number as Table 1, Table 2 etc, and refer to all of them in the text. Each table should be provided on a separate page of the manuscript. Tables should not be included in the text.Each table should have a brief and self-explanatory title. Column headings should be brief, but sufficiently explanatory. Standard abbreviations of units of measurement should be added between parentheses. Vertical lines should not be used to separate columns. Leave some extra space between the columns instead. Any explanations essential to the understanding of the table should be given in footnotes at the bottom of the table.
Number figures as Fig. 1, Fig. 2, etc and refer to all of them in the text. Each figure should be provided on a separate sheet. Figures should not be included in the text. Colour figures can be included, provided the cost of their reproduction is paid for by the author. For the file formats of the figures please take the following into account:
- Line art should be have a minimum resolution of 600 dpi, save as EPS or TIFF
- Grayscales (incl photos) should have a minimum resolution of 300 dpi (no lettering), or 500 dpi (when there is lettering); save as tiff
- Do not save figures as JPEG, this format may lose information in the process
- Do not use figures taken from the Internet, the resolution will be too low for printing
- Do not use colour in your figures if they are to be printed in black & white, as this will reduce the print quality (note that in software often the default is colour, you should change the settings)
- For figures that should be printed in colour, please send a CMYK encoded EPS or TIFF
Figures should be designed with the format of the page of the journal in mind. They should be of such a size as to allow a reduction of 50%. On maps and other figures where a scale is needed, use bar scales rather than numerical ones, i.e., do not use scales of the type 1:10,000. This avoids problems if the figures need to be reduced. Each figure should have a self-explanatory caption. The captions to all figures should be typed on a separate sheet of the manuscript. Photographs are only acceptable if they have good contrast and intensity.
It is possible to have figures printed in colour, provided the cost of their reproduction is paid for by the author. The charges will be specified with the proof delivery. Online the figures will be published in full colour at no charge.
Supplementary material can be submitted with the manuscript, included within the manuscript after the Figures and Tables (or otherwise after the References). Each supplementary item should have a legend and should not exceed the file size of 10MB. Supplemental videos can be submitted separately (see top of page for submission guidelines of videos). A short description of the supplementary items should be included under the header of “Supplementary Material” within the manuscript before the “References”. Supplementary material will be made available in the format in which it was provided. Large datasets should be hosted on the author’s own or institute’s website or in an appropriate database, and should be properly cited within the manuscript.
Authors submitting a manuscript do so on the understanding that they have read and agreed to the terms of the IOS Press Author Copyright Agreement.
Quoting from other publications
An author, when quoting from someone else's work or when considering reproducing figures or table from a book or journal article, should make sure that he is not infringing a copyright. Although in general an author may quote from other published works, he should obtain permission from the holder of the copyright if he wishes to make substantial extracts or to reproduce tables, plates or other figures. If the copyright holder is not the author of the quoted or reproduced material, it is recommended that the permission of the author should also be sought. Material in unpublished letters and manuscripts is also protected and must not be published unless permission has been obtained. Submission of a paper will be interpreted as a statement that the author has obtained all the necessary permission. A suitable acknowledgement of any borrowed material must always be made.
Quoting from Restorative Neurology and Neuroscience
Permissions for use of materials published in RNN Reports (figures, tables, thesis publication) can be requested at firstname.lastname@example.org.
PEER REVIEW POLICY
Restorative Neurology and Neuroscience operates a rigorous, timely, blinded peer review process (with an option for double-blind if requested) by experts in the field. Manuscripts submitted to the Restorative Neurology and Neuroscience will be assessed for suitability for publication in the journal by the Editor-in-Chief. Manuscripts that are deemed unsuitable may be rejected without peer review by the Editor-in-Chief and/or the Associate Editors, and the author will be informed as soon as possible.
Manuscripts that are deemed suitable for peer review are assigned to appropriate anonymous referees (a minimum of two) for confidential review. Referee reports are then assessed by the the Editor-in-Chief. Once approved this decision is then conveyed to the author along with the referees’ anonymized reports.
The initial decision will be one of the following: rejection, acceptance without revision, or potentially acceptable after minor or major revisions. Revised manuscripts will be appraised by the Editor-in-Chief, who may seek the opinion of referees (prior or new) before making a decision. This decision is then conveyed to the author along with the anonymized referees’ reports. Once accepted, manuscripts are normally published on-line without delay and appear in the next available print issue (published quarterly).
The Editor-in-Chief has ultimate responsibility for what is published in the journal. Authors may appeal decisions by contacting the Editor-in-Chief (at email@example.com). Authors will be informed in writing of the result of their appeal.
PRE-PRESS AND PROOFS
Accepted articles will be placed online as "pre-press" articles two weeks after acceptance. The corresponding author will receive the PDF proof around the same time, and is asked to check this proof carefully (the publisher will execute a cursory check only). Corrections other than printer's errors should be avoided. Costs arising from excessive corrections will be charged to the authors. The pre-press file will remain as the uncorrected proof version until the article is published in an issue and the final published version replaces the pre-press file.
OPEN ACCESS MANDATES
A growing number of funding agencies now require that research articles they have funded must be made Open Access. This may be either by mandating deposit in repositories after an embargo period or by stipulating that research is published as Open Access. Publishing in this journal complies with all major funding agency requirements.
COMPLIMENTARY COPY AND PURCHASE
The corresponding author of a contribution to the journal is entitled to receive 1 author’s copy of the pdf free of charge, unless otherwise stated. Free copies will not be provided for conference proceedings and abstract issues.
How to order reprints, a pdf file, journals, or IOS Press books.
An order form for reprints, additional journal copies or a non-watermarked pdf file will be provided along with the pdf proof. If you wish to order reprints of an earlier published article, please contact the publisher for a quotation. IOS Press, Fax: +31 20 6870039. Email: firstname.lastname@example.org. An author is entitled to 25 % discount on IOS Press books. See Author's Discount (25%) on all IOS Press book publications.
Authors of published articles (non-prepress, final articles) will be contacted by Kudos. Kudos is a service that helps researchers maximize the impact and visibility of their research. It allows authors to enrich their articles with lay metadata, add links to related materials and promote their articles through the Kudos system to a wider public. Authors will receive no more than three emails: one invitation and a maximum of two reminders to register for the service and link the published article to their profile. Using and registering for Kudos remains entirely optional. For more information, please have a look at our authors section.
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29 Jun 2020 - Amsterdam NL – The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs). Yet it leads to widely diverse clinical symptoms, suggesting multiple pathogenic mechanisms. Writing in Restorative Neurology and Neuroscience, investigators describe how excessive activation of AhRs via the IDO1-kynurenine-AhR signaling pathway, which is used by many pathogens to establish infection, leads to “Systemic AhR Activation Syndrome” (SAAS). The authors also hypothesize that therapies targeting downregulation of AhRs and IDO1 genes should decrease severity of infection....
22 Jan 2020 - Amsterdam, NL – Progress in research and technology is giving rise to an optimistic future for compensation and restoration of low vision, according to research in a special issue of Restorative Neurology and Neuroscience, published by IOS Press. Seven studies explore different aspects of vision loss after damage to the retina, optic nerve or brain due to diseases such as glaucoma or optic neuropathy. Remarkable progress is being made to treat conditions of partial blindness that have previously been considered irreversible. ...
Hearing Through Your Fingers: Device that Converts Speech to Touch Enables the Hearing-Impaired to Hear Through Their Fingertips
03 Jun 2019 - Amsterdam, NL – A novel study published in Restorative Neurology and Neuroscience provides the first evidence that a simple and inexpensive non-invasive speech-to-touch sensory substitution device has the potential to improve hearing in hearing-impaired cochlear implant patients, as well as individuals with normal hearing, to better discern speech in various situations like learning a second language or trying to deal with the "cocktail party effect." The device can provide immediate multisensory enhancement without any training....
Yoga Regimen Reduces Severity of Rheumatoid Arthritis Symptoms, Alleviates Depression, and Improves Patient Quality of Life
05 Feb 2019 - Amsterdam, NL – According a study published in Restorative Neurology and Neuroscience, eight weeks of intensive yoga practice significantly decreases the severity of physical and psychological symptoms in patients with active rheumatoid arthritis (RA), a debilitating chronic auto-immune inflammatory disease. Marked improvements were seen in the levels of certain inflammatory biomarkers and assessments of functional status and disease activity in patients studied, demonstrating yoga’s promotive, preventive, curative, and rehabilitative potential for achieving optimal health....
02 Oct 2017 - Amsterdam, NL – Video games are quickly becoming a hot topic in cognitive training. Many see them as a potential tool to help patients improve their performance and memory, yet little is known about how different types of video games may affect white matter in the brain and cognition....
05 Jul 2017 - Amsterdam, NL – Stereo vision allows individuals to perceive depth differences in their surroundings. Important to pedestrians and drivers, for example, depth perception plays a key role in many sporting activities. If the ability to accurately determine the distance and speed of a fast-moving object can be improved, athletes have the potential to improve their performance. In a new study published in Restorative Neurology and Neuroscience, researchers found that by training athletes using repetitive stereoscopic stimuli, their reaction speed to those stimuli could be significantly improved....
19 Jun 2017 - Amsterdam, NL – Spasticity, uncontrolled muscle contractions, is a common disorder experienced by patients with spinal cord injuries (SCI). Previous studies have shown that excitatory repetitive transcranial magnetic stimulation (rTMS) can reduce spasticity. In a new study published in Restorative Neurology and Neuroscience, researchers found that a protocol of rTMS, excitatory intermittent theta burst stimulation (iTBS), was successful in reducing spasticity in patients with SCI and therefore may be a promising therapeutic tool....
06 Jun 2017 - IOS Press Neuroscience & Neurology brochure...
03 Aug 2016 - Brain tissue can die as the result of stroke, traumatic brain injury, or neurodegenerative disease. When the affected area includes the motor cortex, impairment of the fine motor control of the hand can result. In a new study published in Restorative Neurology and Neuroscience, researchers found that inosine, a naturally occurring purine nucleoside that is released by cells in response to metabolic stress, can help to restore motor control after brain injury....
01 Apr 2016 - Journals and Books...
15 Jan 2016 - One of the greatest challenges associated with the growing numbers of aged adults is how to maintain a healthy aging mind. Taking up a new mental challenge such as digital photography or quilting may help maintain cognitive vitality, say researchers reporting in Restorative Neurology and Neuroscience. ...
14 Jan 2016 - Graph theoretical analysis is proving to be helpful in understanding complex networks in the brain. Investigators in the Republic of Korea used a graph theoretical approach in examining the changes in the configuration of the two hemispheres of the brain in 12 patients after stroke. They found it helped understand the dynamic reorganization of both hemispheric networks in the brain and to predict recovery of motor function. Their findings are published in Restorative Neurology and Neuroscience....
01 Sep 2015 - About 50% of patients with Parkinson’s disease (PD) experience freezing of gait (FOG), an inability to move forward while walking. This can affect not only mobility but also balance. In a new study published in Restorative Neurology and Neuroscience, researchers report that repetitive transcranial magnetic stimulation (rTMS) can reduce FOG and improve other motor skills in PD patients....
27 Aug 2015 - Patients with relapsing-remitting multiple sclerosis (RR-MS), the most common form of the disease, often have deficits in two neuropsychological functions, autobiographical memory (AM) and episodic future thinking (EFT), which impact quality of life. In a new study published in Restorative Neurology and Neuroscience, researchers report that training RR-MS patients in mental visual imagery (MVI) can improve AM/EFT functioning....
25 Aug 2015 - Bedwetting, or nocturnal enuresis, causes distress in children and young adults, as well as for their parents or caregivers. The causes are not fully understood and there may be both physiological and psychological components to the condition. In a new study published in Restorative Neurology and Neuroscience, researchers report that repetitive sacral root magnetic stimulation (rSMS) can reduce the frequency of nighttime bedwetting and improve quality-of-life for sufferers....
17 Jun 2015 - Human stem cells can be differentiated to produce other cell types, such as organ cells, skin cells, or brain cells. While organ cells, for example, can function in isolation, brain cells require synapses, or connectors, between cells and between regions of the brain. In a new study published in Restorative Neurology and Neuroscience, researchers report successfully growing multiple brain structures and forming connections between them in vitro, in a single culture vessel, for the first time....
Patient Awakes from Post-Traumatic Minimally Conscious State after Administration of Depressant Drug
16 Dec 2014 - A patient who had suffered a traumatic brain injury unexpectedly recovered full consciousness after the administration of midazolam, a mild depressant drug of the GABA A agonists family. This resulted in the first recorded case of an “awakening” from a minimally-conscious state (MCS) using this therapy. Although similar awakenings have been reported using other drugs, this dramatic result was unanticipated. It is reported in Restorative Neurology and Neuroscience. ...
21 Oct 2014 - White Canes provide low-tech assistance to the visually impaired, but some blind people object to their use because they are cumbersome, fail to detect elevated obstacles, or require long training periods to master. Electronic travel aids (ETAs) have the potential to improve navigation for the blind, but early versions had disadvantages that limited widespread adoption. A new ETA, the “EyeCane,” developed by a team of researchers at The Hebrew University of Jerusalem, expands the world of its users, allowing them to better estimate distance, navigate their environment, and avoid obstacles, according to a new study published in Restorative Neurology and Neuroscience. ...
05 Feb 2014 - Using auditory or tactile stimulation, Sensory Substitution Devices (SSDs) provide representations of visual information and can help the blind “see” colors and shapes. SSDs scan images and transform the information into audio or touch signals that users are trained to understand, enabling them to recognize the image without seeing it....
31 Jan 2014 - Download the 2014 Neuroscience Neurology Brochure here. ...
31 Jan 2014 - About 80% of stroke survivors experience hemiparesis, which causes weakness or the inability to move one side of the body. Core stabilization exercise to improve postural stability and independent walking in chronic hemiparetic stroke patients could be enhanced by real-time video feedback, report researchers in Restorative Neurology and Neuroscience....
03 Jan 2014 - Scientists know that vision restoration training (VRT) can help patients who have lost part of their vision due to glaucoma, optic nerve damage, or stroke regain some of their lost visual functions, but they do not understand what factors determine how much visual recovery is achieved. ...
20 Nov 2013 - Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the leading causes of sudden and irreversible loss of vision in older adults. In a prospective randomized trial of 60 patients with NAION, investigators have shown that the addition of the corticosteroid fluocortolone (FC) to standard therapy significantly improves both short- and long-term visual acuity, especially when given soon after the onset of symptoms. Their results are published in Restorative Neurology and Neuroscience....
27 Aug 2013 - Of the 15 million people around the world who have survived poliomyelitis, up to 80% report progressive deteriorating strength and endurance many years after infection, a condition known as post-polio syndrome (PPS). Researchers in Italy from the National Hospital for Poliomyelitis, the Policlinico G.B. De Rossi in Verona, and the University of Milan have found that transcranial direct current stimulation (tDCS) for 15 days improved sleep and fatigue symptoms in patients with PPS, suggesting this non-invasive tool may be a new therapeutic option for this condition. Their results are published in Restorative Neurology and Neuroscience....
New Study Supports Intracerebral Injections of Bone Marrow-Derived Stem Cells to Prevent or Reduce Post-Stroke Cognitive Deficits
26 Aug 2013 - Cognitive deficits following ischemic stroke are common and debilitating, even in the relatively few patients who are treated expeditiously so that clots are removed or dissolved rapidly and cerebral blood flow restored. A new study in Restorative Neurology and Neuroscience demonstrates that intracerebral injection of bone-marrow-derived mesenchymal stem cells (BSCs) reduces cognitive deficits produced by temporary occlusion of cerebral blood vessels in a rat model of stroke, suggesting that BSCs may offer a new approach for reducing post-stroke cognitive dysfunction. ...
20 Aug 2013 - A new study published in Restorative Neurology and Neuroscience demonstrates that Chinese herbal medicine Ji-Sui-Kang (JSK), given systemically for three weeks after injury in rats, improved locomotor function, reduced tissue damage, and preserved the structure of neural cells compared to control rats. The report also includes data showing that JSK may first act to reduce inflammation and cell apoptosis and death, and boost local oxygen supply while, later on, it appears to restore function and promote tissue regeneration. ...
05 Aug 2013 - Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer’s disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum’s neurotoxic effects....
03 Jul 2013 - Multiple sclerosis (MS) can lead to severe cognitive impairment as the disease progresses. Researchers in Italy have found that patients with high educational levels show less impairment on a neuropsychological evaluation compared with those with low educational levels. Their results are published in Restorative Neurology and Neuroscience....
10 Apr 2013 - Repetitive transcranial magnetic stimulation (rTMS) is being increasingly explored as a therapeutic tool for movement disorders associated with deficient inhibition throughout the central nervous system. This includes treatment of focal hand dystonia (FHD), characterized by involuntary movement of the fingers either curling into the palm or extending outward. A new study published in Restorative Neurology and Neuroscience reports short-term changes in behavioral, physiologic, and clinical measures that support further research into the therapeutic potential of rTMS....
04 Apr 2013 - In a study designed to differentiate why some stroke patients recover from aphasia and others do not, investigators have found that a compensatory reorganization of language function to right hemispheric brain regions bodes poorly for language recovery. Patients who recovered from aphasia showed a return to normal left-hemispheric language activation patterns. These results, which may open up new rehabilitation strategies, are available in the current issue of Restorative Neurology and Neuroscience....
02 Apr 2013 - In a mouse model of early Parkinson’s disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the substantia nigra (SN), without the loss of nigral dopaminergic neurons. These findings, which may cast light on the molecular processes involved in the initial stages of PD, are available in the current issue of Restorative Neurology and Neuroscience....
19 Feb 2013 - Administration of the active compound tetrahydroxystilbene glucoside (TSG) derived from the Chinese herbal medicine Polygonum multiflorum Thunb, reversed both overexpression of α-synuclein, a small protein found in the brain, and its accumulation using a mouse model of Alzheimer’s disease. These results, which may shed light on the neuropathology of AD and open up new avenues of treatment, are available in the current issue of Restorative Neurology and Neuroscience....
27 Nov 2012 - Download the 2013 Neuroscience Neurology Brochure here. ...
Abnormal Involuntary Eye Movements in the “Lazy Eye” Disease Amblyopia Linked to Changes in Subcortical Regions of the Brain
17 Oct 2012 - The neural mechanism underlying amblyopia, also called “lazy eye” is still not completely clear. A new study now reports abnormal eye movements of the lazy eye, which suggests that disturbed functioning of eye movement coordination between both eyes and not primarily the dysfunction of the visual cortex may be a cause of amblyopia (Xue-feng Shi et al.)....
Neural Interface for Hand Prosthesis Can Restore Function in Brain Areas Responsible for Motor Control
21 Aug 2012 - Amputation disrupts not only the peripheral nervous system but also central structures of the brain. While the brain is able to adapt and compensate for injury in certain conditions, in amputees the traumatic event prevents adaptive cortical changes. A group of scientists reports adaptive plastic changes in an amputee’s brain following implantation of multielectrode arrays inside peripheral nerves. Their results are available in the current issue of Restorative Neurology and Neuroscience. ...
21 Aug 2012 - Research has found that declines in temporal information processing (TIP), the rate at which auditory information is processed, underlies the progressive loss of function across multiple cognitive systems in the elderly, including new learning, memory, perception, attention, thinking, motor control, problem solving, and concept formation. In a new study, scientists have found that elderly subjects who underwent temporal training improved not only the rate at which they processed auditory information, but also in other cognitive areas. The study is published in the current issue of Restorative Neurology and Neuroscience. ...
16 Aug 2012 - In a study published in the current issue of Restorative Neurology and Neuroscience scientists report that a therapy combining exercise with the neurovascular protective agent S-nitrosoglutathione (GSNO) improved recovery from stroke in a rat model. GSNO is a compound found naturally in the body and it has no known side effects or toxicity. ...
Music to My Eyes: Device Converting Images into Music Helps Individuals without Vision Reach for Objects in Space
09 Jul 2012 - Sensory substitution devices (SSDs) use sound or touch to help the visually impaired perceive the visual scene surrounding them. The ideal SSD would assist not only in sensing the environment but also in performing daily activities based on this input. For example, accurately reaching for a coffee cup, or shaking a friend’s hand. In a new study, scientists trained blindfolded sighted participants to perform fast and accurate movements using a new SSD, called EyeMusic. Their results are published in the July issue of Restorative Neurology and Neuroscience....
02 Jul 2012 - After stroke, patients often suffer from dysphagia, a swallowing disorder that results in greater healthcare costs and higher rates of complications such as dehydration, malnutrition, and pneumonia. In a new study published in the July issue of Restorative Neurology and Neuroscience, researchers have found that transcranial direct current stimulation (tDCS), which applies weak electrical currents to the affected area of the brain, can enhance the outcome of swallowing therapy for post-stroke dysphagia. ...
19 Jun 2012 - Studies suggest that neurotrophic factors, which play a role in the development and survival of neurons, have significant therapeutic and restorative potential for neurologic diseases such as Huntington’s disease. However, clinical applications are limited because these proteins cannot easily cross the blood brain barrier, have a short half-life, and cause serious side effects. Now, a group of scientists has successfully treated neurological symptoms in laboratory rats by implanting a device to deliver a genetically engineered neurotrophic factor directly to the brain. They report on their results in the latest issue of Restorative Neurology and Neuroscience. ...