Journal of Alzheimer’s Disease Reports

An Open Access Journal

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ISSN online
3; 1 issues
Latest content in issue (3:1) online March 2019
Next issue
4:1 scheduled for January 2020
Back volumes
Biochemistry, Medicine & Health, Neurosciences

Sign Up for Mailings – The open access Journal of Alzheimer's Disease Reports (JADR) publishes one volume per year. We issue quarterly mailings and you can sign up for them here. To view the JADR Volume 3 mailing featuring content published during Q1 2019, click here.

JAD News  JADR's older sibling, the Journal of Alzheimer's Disease, publishes 24 volumes per year. Receive updates about new issues by signing up here. JAD had its 20th anniversary in 2018 and the celebratory issue (JAD 62:3) is all open access and you can read more about the content here.

Journal of Alzheimer's Disease Reports is an Open Access international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, hypotheses, and case reports. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.


George Perry, PhD
College of Sciences
University of Texas at San Antonio
One UTSA Circle
San Antonio, Texas 78249, USA
Tel: +1.210.458.4450
ORCID iD: 0000-0002-6547-0172

Managing Editor

Beth Kumar
Department of Pathology
Case Western Reserve University
2103 Cornell Road
Cleveland, Ohio 44106, USA
Tel: +1.216.502.2019

Associate Editors

J. Wesson Ashford, MD, PhD
Stanford School of Medicine; Palo Alto VA Health Care System, Palo Alto, CA, USA

Craig S. Atwood, PhD
University of Wisconsin-Madison, Madison, USA

Jesús Ávila, MD
Universidad Autónoma de Madrid, Madrid, Spain

Rudy J. Castellani, MD
Western Michigan University, Kalamazoo, MI, USA

Sergio T. Ferreira, PhD
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

Robert Friedland, MD
University of Louisville, Louisville, KY, USA

Daniela Galimberti, PhD
University of Milan, Milan, Italy

Alan Lerner, MD
Case Western Reserve University, Cleveland, OH, USA

Ricardo Maccioni, PhD
International Center for Biomedicine, Santiago, Chile

Patrizia Mecocci, MD, PhD
University of Perugia, Perugia, Italy

Paula Moreira, PhD
University of Coimbra, Coimbra, Portugal

Akihiko Nunomura, MD, PhD
University of Yamanashi, Yamanashi, Japan

Giulio Maria Pasinetti, MD, PhD
Mount Sinai School of Medicine, New York, NY, USA

Marwan N. Sabbagh, MD
Barrow Neurological Institute, Phoenix, AZ, USA

Thomas B. Shea, PhD
UMass Lowell, Lowell, MA, USA

Massimo Tabaton, MD
University of Genova, Genova, Italy

Xiongwei Zhu, PhD
Case Western Reserve University, Cleveland, OH, USA


Journal papers will be published Open Access (OA). The article will be freely available from the moment it is published, also in the pre-print module. The article processing charges are $1450 and EUR1250.

See our website for more information about our Open Access policy: IOS Press Open Library®.


By submitting my article to this journal, I agree to the IOS Press License to Publish: and the IOS Press Privacy Policy:

Authors are requested to submit their manuscript electronically to the journal’s editorial management system.

This journal operates with single-blind peer review. If the author prefers double-blind peer review, then please submit your manuscript excluding the author listing and make sure your document is anonymized, and list your authors and affiliations only in the cover letter for the Editor.

Note that the manuscript should be uploaded as one file with tables and figures included. This file can be a Word document, a PDF, or an embedded zip file (.zip) if separate high resolution figures or a supplemental file such as a video are also to be included with the submission (the file size maximum for a video is 25MB). If the video is too large to submit, please contact to arrange a file transfer. For more information about submitting supplementary data see “Supplementary Material.”

Resubmissions should include the manuscript number in the cover letter. Resubmissions should clearly mention that the submission is a Revision and include the reference number in the submission letter. The author's replies to the reviewer comments should be included in the revised manuscript itself (at the top). The revised paper should always be a Word document.

Submission of a Review paper should be clearly mentioned in the cover letter to help the editorial process.

Submission of an article is understood to imply that the article is original and unpublished and is not being considered for publication elsewhere. Any possible conflict of interest, financial or otherwise, related to the submitted work must be clearly indicated in the manuscript. Procedures involving experiments on human subjects should be in accord with the ethical standards of the Committee on Human Experimentation of the institution in which the experiments were done or in accord with the Helsinki Declaration of 1975. Procedures involving experimentation on animal subjects should be in accord with either the guide of the institution in which the experiments were done, or with the National Research Council’s guide for the care and use of laboratory animals.

If the address to which proofs should be sent is different from the correspondence address, authors are kindly requested to indicate this. Both the editor and the publisher should be informed of any changes in either or both of these addresses. Please also supply a direct telephone number, if available.

Note that all accepted papers are subject to payment of an Open Access Fee of $725 / EUR690.


Research Reports

Organization and presentation style

  1. Manuscripts must be written in English. Authors whose native language is not English are recommended to seek the advice of a native English speaker, if possible, before submitting their manuscripts. You can also visit Peerwith. Peerwith offers a language and copyediting service to all scientists who want to publish their manuscript in scientific peer-reviewed periodicals and books.
  2. Manuscripts should be double spaced throughout with wide margins (2.5cm or 1in), including the abstract and references. Every page of the manuscript, including the title page, references, tables, etc., should include a page number centered at the bottom.
  3. Manuscripts should be organized in the following order with headings and subheadings typed on a separate line, without indentation.
  4. Nomenclature for amyloids should follow the 2014 guidelines of the Nomenclature Committee of the International Society of Amyloidosis (Amyloid 21, 221–224, 2014), e.g., amyloid-β (Aβ) and amyloid-β protein precursor (AβPP). Also preferred is Aβ42 and sAβPPα.

Title page

  • Title (should be clear, descriptive and concise).
  • Full name(s) of author(s).
  • Full affiliation(s). Delineate affiliations with lowercase letters.
  • Present address of author(s), if different from affiliation.
  • Running title (45 characters or less, including spaces).
  • Complete correspondence address, including telephone number and email address.

Changes in Authorship

When submitting the manuscript the author listing and order should be final. If any addition, deletion or rearrangement of author names in the authorship list does need to be made after submission, this can be done only before acceptance and with the Editor’s approval. To request such a change, the Editor must receive the following from the corresponding author: (1) the reason for the change in author list and (2) written confirmation from all authors, including the affected author, that they agree with the addition, removal or rearrangement. Only in exceptional circumstances will the Editor consider the addition, deletion or rearrangement of authors after the manuscript has been accepted. While the Editor considers the request, publication of the manuscript will be suspended. If the manuscript has already been published in an issue, any requests approved by the Editor will result in an Erratum.

Abstract and Keywords

The abstract for research papers should follow a structured format: BACKGROUND, OBJECTIVE, METHODS, RESULTS, CONCLUSIONS. Do not include these as headings. Ideally, the abstract should be no longer than 250 words.

For other papers such as Reviews, the abstract should be clear, descriptive, and self-explanatory, and no longer than 250 words.

Include a list of 4-10 keywords. These keywords should be terms from the MeSH database.


Provide enough information to put your work into context. Be concise!  Clearly address the following points:

  • What information is already available?
  • What is the rationale or reason for your research?
  • What problem(s) does it address?

Do NOT include a comprehensive literature review of your research. End the Introduction by clearly stating the aims of your study.

Materials and Methods

This section should be well structured and detailed enough for others to be able to reproduce your experiments. Use clear sub-headings throughout. Start by describing the materials use, the supplier source, including any relevant catalog information, and supplier location. Use references appropriately to refer to published protocols or methodology. Do NOT repeat a detailed description of an already-published method or protocol.  


This section should present the results and summarise the findings of your study. Do not provide any data in great detail. If you need to include additional detailed data, do so in supplementary files submitted with the paper. Consider providing a one-sentence summary at the beginning of each paragraph in the Results section, if you think that this would help the reader in understanding your findings.


You should begin this section with a brief summary of the main findings. Ensure that you answer all the questions posed in the Introduction. Mention both the strengths and the limitations for your study, as well as applications and implications of your findings. Compare these to other published findings.

Acknowledgments including sources of support

Include individuals or companies which have assisted with your study, including advisors, funding sources, administrative support and suppliers who may have donated or given materials used in the study.

Conflict of Interest 

If there is no conflict of interest to declare, do still include this section and insert "The authors have no conflict of interest to report".


(Download the EndNote style from EndNote: same as JAD ( A .csl file is available here.)

  1. Place citations as numbers in square brackets in the text in order of appearance. Each citation should be to one manuscript only. All publications cited in the text should be presented in a list of references following the text of the manuscript. Only articles published or accepted for publication should be listed in the reference list. Submitted articles can be listed in the text as (Author(s), unpublished data).
  2. All authors should be listed in the reference list.
  3. Please include doi numbers for "in press" articles if available. 
  4. References should be listed in the order of appearance in the following style:

[1] Alzheimer Research Forum, Drugs in Clinical Trials: AAB-001,, Last updated May 29, 2007, Accessed on January 29, 2008.
[2] Smith MA (2006) Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss! In Alzheimer's Disease: A Century of Scientific and Clinical Research, Perry G, Avila J, Kinoshita J, Smith MA, eds. IOS Press, Amsterdam, pp. 305-308.
[3] Higuma M, Sanjo N, Mitoma H, Yoneyama M, Yokota T (2017) Whole-day gait monitoring in patients with Alzheimer’s disease: a relationship between attention and gait cycle. J Alzheimers Dis Rep 1, 1-8.
[4] Paxinos G, Watson C (1986) The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney.
[5] Zhu X, Perry G, Smith MA (2004) Two hits and you're out? A novel mechanistic hypothesis of Alzheimer disease, Alzheimer Research Forum,, Posted 23 October 2004, Accessed 29 January 2008.

Datasets and Data Articles

All datasets and data articles referenced in your manuscript should be cited in the main reference list of your article (not in a separate box or in the article text).


Number according to their sequence in the text. The text should include references to all tables. Provide each table on a separate page of the manuscript after the references. Include a brief and self-explanatory title with any explanations essential to the understanding of the table given in footnotes at the bottom of the table. Vertical lines should not be used to separate columns. Leave some extra space between the columns instead. Citations in the tables should be numbered and included in the Reference list.

Figures and Figure Legends

Number the figures according to their sequence in the text. The text should include references to all figures.

  • Figures should preferably be formatted in TIF or EPS format. JPG is also acceptable.
  • Figures should be designed with the format of JAD Reports in mind and preferable sized as they will appear when printed. A single column of the journal is 77mm and two columns are 165mm.
  • Figures should be at 300 dpi or higher and be cropped to include the figure only (no blank space). CMYK is preferred for color figures.
  • On figures where a scale is needed, use bar scales to avoid problems if the figure needs to be reduced.
  • Each illustration should have a brief self-explanatory legend that should be typed separately from the figure in the section of the manuscript following the tables.

Supplementary Material

Supplementary material can be submitted with the manuscript, included within the manuscript after the Figures and Tables (or otherwise after the References). Each supplementary item should have a legend and should not exceed the file size of 10MB. Supplemental videos can be submitted separately (see top of page for submission guidelines of videos). A short description of the supplementary items should be included under the header of “Supplementary Material” within the manuscript before the “References”. Supplementary material will be made available in the format in which it was provided. Large datasets should be hosted on the author’s own or institute’s website or in an appropriate database, and should be properly cited within the manuscript.

Reviews Articles

Reviews should be authoritative and topical and provide comprehensive and balanced coverage of a timely and/or controversial issue. Reviews should be prepared as detailed above for a Research Report, omitting Introduction through Discussion, and include a conclusion.

Short Communications 

A Short Communication is an article of original scholarship of unusual interest of less than 2000 words (not including references). An abstract of 100 words or less should be included with no subdivison of text into sections. A maximum of 20 References should be included and formatted as above. A total of three tables and/or figures are allowed.


A hypothesis article should be a balanced and insightful consideration of a topic with novel hypotheses well presented and supported. The article should be prepared as a Research Report but without Methods or Results sections. 


In cover letter:

  • Name, postal address, phone number and email address of the corresponding author.
  • Name of an Editorial Board member with expertise in the area of the study (if no Editorial Board member is suitable, the Editorial Office will handle the submission).
  • Statement that all authors have contributed to the work, agree with the presented findings, and that the work has not been published before nor is being considered for publication in another journal.
  • A list of at least 4-6 potential reviewers knowledgeable in the area of the study and potential reviewer conflicts.
  • Statement that procedures involving experiments on human subjects are done in accord with the ethical standards of the Committee on Human Experimentation of the institution in which the experiments were done or in accord with the Helsinki Declaration of 1975.
  • Statement that procedures involving experimentation on animal subjects are done in accord with either the guide of the institution in which the experiments were done, or with the National Research Council's guide for the care and use of laboratory animals.

In manuscript:

  • Compliance with guidelines on human experimentation as well as protocol approval by a local Institutional Review Board should be specified.
  • Compliance with guidelines of animal experimentation as well as protocol approval by the Institutional Animal Care and Use Committee should be specified.
  • Statement of all financial and material support for this research and any potential conflicts should also be clearly identified in the Acknowledgment and Conflict of Interest sections. If there is no Conflict of Interest then still add this statement.


Resubmissions should include the manuscript number and a reference that the paper is a revision. The point-by-point response to the previous reviews should be included at the top of the manuscript.

Financial Disclosure

All affiliations with or financial involvement (e.g., employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, royalties) with any organization or entity with a financial interest in or in financial competition with the subject matter or materials discussed in the manuscript are completely disclosed in the letter of submission. All financial and material support for this research and work are clearly identified in the manuscript including listing of support specified in the letter of submission that might constitute or give the appearance of influencing the findings, based on the judgment of the Editor-in-Chief in consultation with the Editor handling the review of the manuscript.


Accepted articles will be placed online as "pre-press" articles two weeks after acceptance. The corresponding author will receive the PDF proof around the same time, and is asked to check this proof carefully (the publisher will execute a cursory check only). Corrections other than printer's errors should be avoided. Costs arising from excessive corrections will be charged to the authors. Once the author corrections are received, the proof will be corrected accordingly and published in final form in the running volume of the journal. This last process will also take about 2 weeks.

Policy regarding Funding Agencies’ Access Policy mandate (PubMed Central)

If requested by the author, Research Councils UK (RCUK) and Wellcome Trust funded Open Access articles will be published under the mandated terms of the Creative Commons Attribution License (CC-BY). After acceptance of their article, the author can select the preferred CC-BY license in the provided Open Access payment form, which is linked in the acceptance letter.

JAD Reports is a full Open Access journal, which helps authors to comply with major funder mandates. Because JAD Reports is a newly-launched journal it is currently not yet able to deposit articles directly into Pubmed Central for the author, and the author must do this themselves. IOS Press grants authors permission to freely deposit the published PDF to PubMed Central and affiliated repositories after final publication in an issue with no embargo period. The guidelines for PubMed Central submission can be found here (follow Submission Method C). As soon as JAD Reports has passed the Pubmed Central application review, IOS Press will be able to deposit the articles for the authors directly on publication, and these instructions will be updated accordingly. Of course it is a priority to the Editors and Publisher to have this journal listed into Pubmed Central as soon as possible to optimize our service to our authors.

If requested by the author, Research Councils UK (RCUK) and Wellcome Trust funded Open Access articles will be published under the terms of the Creative Commons Attribution License (CC-BY). After acceptance of their article, the author should send a separate message to the publisher at to notify that their article (include reference number) should be published Open Access under the RCUK mandate. An extra fee applies for CC-BY publications. Here also the author must make the deposit to Pubmed Central themselves using Submission Method C until JAD Reports has been accepted by Pubmed Central.


Copyright of your article

Authors submitting a manuscript do so on the understanding that they have read and agreed to the terms of the IOS Press Author Copyright Agreement.

Quoting from other publications 

An author, when quoting from someone else's work or when considering reproducing figures or table from a book or journal article, should make sure that he is not infringing a copyright. Although in general an author may quote from other published works, he should obtain permission from the holder of the copyright if he wishes to make substantial extracts or to reproduce tables, plates or other figures. If the copyright holder is not the author of the quoted or reproduced material, it is recommended that the permission of the author should also be sought. Material in unpublished letters and manuscripts is also protected and must not be published unless permission has been obtained. Submission of a paper will be interpreted as a statement that the author has obtained all the necessary permission. A suitable acknowledgement of any borrowed material must always be made.

Quoting from Journal of Alzheimer’s Disease Reports

Permissions for use of materials published in JAD Reports (figures, tables, thesis publication) can be requested at


Complimentary copy 

The articles will be freely available in the online contents and can be used according to the CC-BY-NC (non-commercial) license. There is no embargo period.

How to order reprints, journals, or IOS Press books

JAD Reports is published online only. To order commercial reprints, please contact the publisher for a quotation. IOS Press, Fax: +31 20 6870039. Email:

An author is entitled to 25% discount on IOS Press books. See Author's Discount (25%) on all IOS Press book publications.


Authors of published articles (non-prepress, final articles) will be contacted by Kudos. Kudos is a service that helps researchers maximize the impact and visibility of their research. It allows authors to enrich their articles with lay metadata, add links to related materials and promote their articles through the Kudos system to a wider public. Authors will receive no more than three emails: one invitation and a maximum of two reminders to register for the service and link the published article to their profile. Using and registering for Kudos remains entirely optional. For more information, please have a look at our authors section.


Would you like some pointers on how to help your research achieve a wider reach and greater impact? Please consult our Promotional Toolkit for Authors for tips.


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