Clinical Hemorheology and Microcirculation
Blood Flow, Vessels and Imaging
Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
SUBMISSION OF MANUSCRIPTS
Authors are requested to submit their manuscript electronically to the journal’s editorial management system.
Note that the manuscript should be uploaded as one file with tables and figures included. This file can be a Word document, a PDF, or a zip file.
From 1 August 2016 there is a publication fee for articles submitted on or after this date, and that are accepted for publication.
Authors pay 300 EUR (340 USD) for an accepted article. Page charges do not apply to feature articles.
Required files for final submissions
After the article has been accepted, the authors should submit the final version as source files, including a word processor file of the text, such as Word or LateX (If using LaTeX, please use the standard article.sty as a style file and also send a PDF version of the LaTeX file).
It is possible to have figures printed in colour, provided the cost of their reproduction is paid for by the author. See Preparation of Manuscripts for the required file formats.
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See also our website for more information about this option IOS Press Open Library®
This journal publishes all its articles in the IOS Press pre-press module. By publishing articles ahead of print the latest research can be accessed much quicker. The pre-press articles are the uncorrected proof versions of the article and are published online shortly after the proof is created. At the same time, the pre-press articles are indexed by PubMed where they appear as [Epub ahead of print]. Pre-press articles are fully citable by using the DOI number.
As soon as the pre-press article is assigned to an issue, the author corrections will be incorporated and final bibliographic information will be added. The pre-press version will then be replaced by the updated, final version.
PREPARATION OF MANUSCRIPTS
Organization of the paper and style of presentation
Manuscripts must be written in English. Authors whose native language is not English are advised to seek the advice of a native English speaker, before submitting their manuscripts.
Peerwith offers a language and copyediting service to all scientists who want to publish their manuscript in scientific peer-reviewed periodicals and books.
Manuscripts should be prepared with wide margins and double spacing throughout, including the abstract, footnotes and references. Every page of the manuscript, including the title page, references, tables, etc., should be numbered. However, in the text no reference should be made to page numbers; if necessary, one may refer to sections. Try to avoid the excessive use of italics and bold face.
Manuscripts should be organized in the following order:
Headings and subheadings should be numbered and typed on a separate line, without indentation.
SI units should be used, i.e., the units based on the metre, kilogramme, second, etc.
The title page should provide the following information:
Each paper submitted must be accompanied by an abstract which does not exceed 200 words. It should state concisely the reason for the study, what was done, what was found, what was concluded, and the relevance of the work.
The abstract for research papers should follow the “structured abstract” format. Section labels should be in bold uppercase letters followed by a colon, and each section will begin on a new line.
Number as Table 1, Table 2 etc, and refer to all of them in the text.
Each table should be provided on a separate page of the manuscript. Tables should not be included in the text.
Each table should have a brief and self-explanatory title.
Column headings should be brief, but sufficiently explanatory. Standard abbreviations of units of measurement should be added between parentheses.
Vertical lines should not be used to separate columns. Leave some extra space between the columns instead.
Any explanations essential to the understanding of the table should be given in footnotes at the bottom of the table.
Authors are requested to use the Vancouver citation style. Place citations as numbers in square brackets in the text. All publications cited in the text should be presented in a list of references at the end of the manuscript. List the references in the order in which they appear in the text. Only articles published or accepted for publication should be listed in the reference list. Submitted articles can be listed as (author(s), unpublished data). If an article has a DOI, this should be provided after the page number details. Manuscripts will not be considered if they do not conform to the Vancouver citation guidelines.
References must be listed in Vancouver style:
 Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002;935(1-2):40-6.
 Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA. Medical microbiology. 4th ed. St. Louis: Mosby; 2002.
 Berkow R, Fletcher AJ, editors. The Merck manual of diagnosis and therapy. 16th ed. Rahway (NJ): Merck Research Laboratories; 1992.
 Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGrawHill; 2002. p. 93-113.
 Canadian Cancer Society [homepage on the Internet]. Toronto: The Society; 2006 [updated 2006 May 12; cited 2006 Oct 17]. Available from: www.cancer.ca/.
 Tian D, Araki H, Stahl E, Bergelson J, Kreitman M. Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci U S A. In press 2002.
 Fletcher D, Wagstaff CRD. Organisational psychology in elite sport: its emergence, application and future. Psychol Sport Exerc. 2009;10(4):427-34. doi:10.1016/j.psychsport.2009.03.009.
Footnotes should only be used if absolutely essential. In most cases it is possible to incorporate the information in the text.
- If used, they should be numbered in the text, indicated by superscript numbers and kept as short as possible.
Number figures as Fig. 1, Fig. 2, etc and refer to all of them in the text.
Each figure should be provided on a separate sheet. Figures should not be included in the text.
Colour figures can be included, provided the cost of their reproduction is paid for by the author.
For the file formats of the figures please take the following into account:
Figures should be designed with the format of the page of the journal in mind. They should be of such a size as to allow a reduction of 50%.
On maps and other figures where a scale is needed, use bar scales rather than numerical ones, i.e., do not use scales of the type 1:10,000. This avoids problems if the figures need to be reduced.
Each figure should have a self-explanatory caption. The captions to all figures should be typed on a separate sheet of the manuscript.
Photographs are only acceptable if they have good contrast and intensity.
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Authors submitting a manuscript do so on the understanding that they have read and agreed to the terms of the IOS Press Author Copyright Agreement.
Quoting from other publications
An author, when quoting from someone else's work or when considering reproducing figures or table from a book or journal article, should make sure that he is not infringing a copyright. Although in general an author may quote from other published works, he should obtain permission from the holder of the copyright if he wishes to make substantial extracts or to reproduce tables, plates or other figures. If the copyright holder is not the author of the quoted or reproduced material, it is recommended that the permission of the author should also be sought. Material in unpublished letters and manuscripts is also protected and must not be published unless permission has been obtained. Submission of a paper will be interpreted as a statement that the author has obtained all the necessary permission. A suitable acknowledgement of any borrowed material must always be made.
The corresponding author will receive a PDF proof and is asked to check this proof carefully (the publisher will execute a cursory check only). Corrections other than printer's errors, however, should be avoided. Costs arising from such corrections will be charged to the authors.
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20 Dec 2012 - Anniversary issue published with review articles on developments in the field ...
Winner of the A.L. Copley Best Paper Prize 2017:
Zsolt Marton, MD
Zsolt Marton works as an assistant professor at the University of Pecs Medical School. He is a specialist in internal medicine, cardiology and intensive care. He graduated at the Medical University of Pecs, Hungary in 1999. As the head of the Intensive Care Unit of the 1st Department of Medicine, University of Pecs he takes part in the care of critically ill and cardiology patients and manages the activities of the ICU. He participates in the education of both medical students and PhD trainees. His research initially focused on the effect of free radicals on hemorheologic parameters, methodological aspects of hemorheology, then mainly on the relation of hemodynamic and hemorheologic parameters in the field of cardiology and intensive care. His special interest is to investigate the rheological parameters and microcirculation in seriously altered hemodynamic state. He is a member of the Hungarian Society of Hemorheology, Hungarian Society of Cardiology and Hungarian Society of Anesthesiology and Intensive Therapy.
"The relationship between hemorheological parameters and mortality in critically ill patients with and without sepsis" K. Totsimon, K. Biro, Z.E. Szabo, K. Toth, P. Kenyeres and Z. Marton Clinical Hemorheology and Microcirculation 65(2), 2017, 119-129. doi: 10.3233/CH-16136.
The authors investigated the prognostic role of hemorheological parameters in critical ill patients. They compared the changes of rheological variables to hemodynamic alterations and to well-known prognostic scores. Patients treated on intensive care unit with different non-surgical diseases were studied. Routine laboratory parameters and prognostic scores (APACHE, SAPS) were determined and hemorheological variables (hematocrit, plasma and whole blood viscosity, red blood cell aggregation and deformability) were measured an different time points. Whole blood viscosity and red blood cell deformability were found lower, red blood cell aggregation higher in septic than in nonseptic patients. In nonseptic patients whole blood viscosity, red blood cell aggregation were higher in nonsurvivors compared to survivors. Worsening of red blood cell deformability predicted higher mortality. Their findings prove that rheological parameters (especially red blood cell aggregation deformability) could predict mortality in severely ill patients and they may add prognostic information over the routine ICU scores.
Winner of the A.L. Copley Best Paper Prize 2016:
Thomas Neumann, MD
T. Neumann, M. Baertschi, W. Vilser, S. Drinda, M. Franz, A. Bruckmann, G. Wolf and C. Jung
“Retinal vessel regulation at high altitudes”
Clin Hemorheol Microcirc 63 (2016), 281-292. doi: 10.3233/CH-162041.
The authors set up a two parts study where 1) healthy individuals were exposed to a simulated altitude of 5500 meters and 2) a second group of healthy individuals were brought to a mountain station at an altitude of 3000 meters. In the second part of the study, individuals were also treated with a dual endothelin (ET) receptor antagonist that binds the two ET receptor subtypes, ETA and ETB. The authors investigated the retinal vessel diameter, response to flicker light, retinal oxygen saturation and retinal venous pressure in the different experimental conditions. Both hypoxic exposures caused an increase of retinal arterial and venous diameters and a decrease of the arterial and venous response to flicker light. In the second part of the study, retinal venous pressure increased in 6 individuals after ascent to 3000 meters and normalized after dual ET receptor antagonist. This finding clearly shows that hypoxia may disturb retinal vascular reactivity in apparently healthy individuals and highlight the effects of blocking ET receptors in such an environmental situation.