Clinical Hemorheology and Microcirculation
Blood Flow, Vessels and Imaging
Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
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From 1 August 2016 there is a publication fee for articles submitted on or after this date, and that are accepted for publication.
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PREPARATION OF MANUSCRIPTS
Organization of the paper and style of presentation
Manuscripts must be written in English. Authors whose native language is not English are advised to seek the advice of a native English speaker, before submitting their manuscripts.
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Manuscripts should be prepared with wide margins and double spacing throughout, including the abstract, footnotes and references. Every page of the manuscript, including the title page, references, tables, etc., should be numbered. However, in the text no reference should be made to page numbers; if necessary, one may refer to sections. Try to avoid the excessive use of italics and bold face.
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The abstract for research papers should follow the “structured abstract” format. Section labels should be in bold uppercase letters followed by a colon, and each section will begin on a new line.
Number as Table 1, Table 2 etc, and refer to all of them in the text.
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Each table should have a brief and self-explanatory title.
Column headings should be brief, but sufficiently explanatory. Standard abbreviations of units of measurement should be added between parentheses.
Vertical lines should not be used to separate columns. Leave some extra space between the columns instead.
Any explanations essential to the understanding of the table should be given in footnotes at the bottom of the table.
Authors are requested to use the Vancouver citation style. Place citations as numbers in square brackets in the text. All publications cited in the text should be presented in a list of references at the end of the manuscript. List the references in the order in which they appear in the text. Only articles published or accepted for publication should be listed in the reference list. Submitted articles can be listed as (author(s), unpublished data). If an article has a DOI, this should be provided after the page number details. Manuscripts will not be considered if they do not conform to the Vancouver citation guidelines.
References must be listed in Vancouver style:
 Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002;935(1-2):40-6.
 Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA. Medical microbiology. 4th ed. St. Louis: Mosby; 2002.
 Berkow R, Fletcher AJ, editors. The Merck manual of diagnosis and therapy. 16th ed. Rahway (NJ): Merck Research Laboratories; 1992.
 Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGrawHill; 2002. p. 93-113.
 Canadian Cancer Society [homepage on the Internet]. Toronto: The Society; 2006 [updated 2006 May 12; cited 2006 Oct 17]. Available from: www.cancer.ca/.
 Tian D, Araki H, Stahl E, Bergelson J, Kreitman M. Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci U S A. In press 2002.
 Fletcher D, Wagstaff CRD. Organisational psychology in elite sport: its emergence, application and future. Psychol Sport Exerc. 2009;10(4):427-34. doi:10.1016/j.psychsport.2009.03.009.
Footnotes should only be used if absolutely essential. In most cases it is possible to incorporate the information in the text.
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Number figures as Fig. 1, Fig. 2, etc and refer to all of them in the text.
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20 Dec 2012 - Anniversary issue published with review articles on developments in the field ...
Winner of the A.L. Copley Best Paper Prize 2019:
Simone Dinarelli, Marco Girasole and Francesco Misiti "Amyloid β peptide affects erythrocyte morphology: Role of intracellular signaling pathways" Clinical Hemorheology and Microcirculation 71(4), 2019, 437-449. doi: 10.3233/CH-199007.
"S. Dinarelli and colleagues received the Prize for their prospective study about the relationship between amyloid peptide and erythrocyte morphology and the role of intracellular pathways. The study revealed that amyloid ß treatment accelerated the occurrence of morphological and biochemical aging markers in human red blood cells and influenced the cell metabolism. Biochemical data demonstrated that contemporaneously to morphological alterations, Aβ triggers: (i) metabolic alterations and (ii) a complex signaling pathway involving caspase 3, protein kinase C and nitric oxide derived metabolites. The study provides an insight how amyloid ß treatment of RBC induced changes in specific cell signalling events and/or metabolic pathways, in turns affecting the membrane-cytoskeleton interaction and the membrane integrity." [ F. Jung, P. Connes, C. Lehmann, A.L. Copley Best Paper Prize 2019, Clin Hemorheol Microcirc 75(1) (2020), doi: 10.3233/CH-209100]
Winner of the A.L. Copley Best Paper Prize 2018:
David N. Naumann
David Naumann is an honorary clinical lecturer at the University of Birmingham, and honorary research fellow at Imperial College London. He graduated from medical school at the University of Cambridge in 2006 and joined the Royal College of Surgeons in 2008. His PhD research was undertaken at the University of Birmingham, where he investigated early microcirculatory dysfunction following traumatic haemorrhagic shock. He is currently a member of the faculty for the Trauma Sciences MSc at the University of Birmingham, and works as a surgical registrar in the West Midlands, as part of the UK Defence Medical Services. His ongoing research interests include trauma immunology, and the response of the endothelium, circulating immune cells and microcirculation to trauma and haemorrhagic shock.
"Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: A prospective observational study" D.N. Naumann, J. Hazeldine, J. Bishop, M.J. Midwinter, P. Harrison, G. Nash and S.D. Hutchings. Clinical Hemorheology and Microcirculation 71(1), 2019, 71-82. doi: 10.3233/CH-180397.
The authors tested the hypothesis that changes in plasma viscosity affect microcirculatory flow following injury and haemorrhagic shock. There is evidence from preclinical studies (particularly small animal models) that increased plasma viscosity may improve flow, but this had not yet been tested in a clinical setting. This is particularly important because viscosity may be a physical property of importance when designing and selecting resuscitation fluids. The authors were the first to compare microcirculatory flow parameters (using sublingual incident dark field video-microscopy) with plasma viscosity (measured using a Wells-Brookfield cone and plate micro-viscometer) in a cohort of patients admitted to hospital following major trauma. They found no evidence of improved microcirculatory flow in the presence of higher viscosity, which seems to contrast with evidence from animal studies. These findings cast some doubt on the translatability of animal studies to more complex clinical scenarios, and suggest that further investigations are required to determine whether the viscosity of resuscitation fluid is indeed a factor of relevance in clinical practice.
Winner of the A.L. Copley Best Paper Prize 2017:
Zsolt Marton, MD
Zsolt Marton works as an assistant professor at the University of Pecs Medical School. He is a specialist in internal medicine, cardiology and intensive care. He graduated at the Medical University of Pecs, Hungary in 1999. As the head of the Intensive Care Unit of the 1st Department of Medicine, University of Pecs he takes part in the care of critically ill and cardiology patients and manages the activities of the ICU. He participates in the education of both medical students and PhD trainees. His research initially focused on the effect of free radicals on hemorheologic parameters, methodological aspects of hemorheology, then mainly on the relation of hemodynamic and hemorheologic parameters in the field of cardiology and intensive care. His special interest is to investigate the rheological parameters and microcirculation in seriously altered hemodynamic state. He is a member of the Hungarian Society of Hemorheology, Hungarian Society of Cardiology and Hungarian Society of Anesthesiology and Intensive Therapy.
"The relationship between hemorheological parameters and mortality in critically ill patients with and without sepsis" K. Totsimon, K. Biro, Z.E. Szabo, K. Toth, P. Kenyeres and Z. Marton Clinical Hemorheology and Microcirculation 65(2), 2017, 119-129. doi: 10.3233/CH-16136.
The authors investigated the prognostic role of hemorheological parameters in critical ill patients. They compared the changes of rheological variables to hemodynamic alterations and to well-known prognostic scores. Patients treated on intensive care unit with different non-surgical diseases were studied. Routine laboratory parameters and prognostic scores (APACHE, SAPS) were determined and hemorheological variables (hematocrit, plasma and whole blood viscosity, red blood cell aggregation and deformability) were measured an different time points. Whole blood viscosity and red blood cell deformability were found lower, red blood cell aggregation higher in septic than in nonseptic patients. In nonseptic patients whole blood viscosity, red blood cell aggregation were higher in nonsurvivors compared to survivors. Worsening of red blood cell deformability predicted higher mortality. Their findings prove that rheological parameters (especially red blood cell aggregation deformability) could predict mortality in severely ill patients and they may add prognostic information over the routine ICU scores.
Winner of the A.L. Copley Best Paper Prize 2016:
Thomas Neumann, MD
T. Neumann, M. Baertschi, W. Vilser, S. Drinda, M. Franz, A. Bruckmann, G. Wolf and C. Jung
“Retinal vessel regulation at high altitudes”
Clin Hemorheol Microcirc 63 (2016), 281-292. doi: 10.3233/CH-162041.
The authors set up a two parts study where 1) healthy individuals were exposed to a simulated altitude of 5500 meters and 2) a second group of healthy individuals were brought to a mountain station at an altitude of 3000 meters. In the second part of the study, individuals were also treated with a dual endothelin (ET) receptor antagonist that binds the two ET receptor subtypes, ETA and ETB. The authors investigated the retinal vessel diameter, response to flicker light, retinal oxygen saturation and retinal venous pressure in the different experimental conditions. Both hypoxic exposures caused an increase of retinal arterial and venous diameters and a decrease of the arterial and venous response to flicker light. In the second part of the study, retinal venous pressure increased in 6 individuals after ascent to 3000 meters and normalized after dual ET receptor antagonist. This finding clearly shows that hypoxia may disturb retinal vascular reactivity in apparently healthy individuals and highlight the effects of blocking ET receptors in such an environmental situation.