Clinical Hemorheology and Microcirculation

Blood Flow, Vessels and Imaging

Share this journal
impact factor 2020 1.741
ISSN print
ISSN online
77-79; 12 issues
Last issue (78:1) online on 04 June 2021
Next issue
78:2 scheduled for July 2021
Back volumes
Biochemistry, Medicine & Health
Subscribe to Online

Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.

The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.

Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.

The following professionals and institutions will benefit most from subscribing to Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.

Important new topics will increasingly claim more pages of Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.

Brandenburg University of Technology
Institute of Biotechnology, Molecular Cell Biology
Senftenberg, Germany

Department of Plastic, Hand and Reconstructive Surgery
University Hospital Regensburg, Germany

Università degli Studi di Palermo, Italy

Université Claude Bernard Lyon, France

Catholic Kwandong University, South Korea

Dalhousie University, Halifax, Canada

Founding Editors

Honorary Editors-in-Chief

Honorary Members

Section Editors

B. AMANN-VESTI, University Hospital Zürich, Switzerland
M.R. BOISSEAU, Bordeaux University, France
R. KOPPENSTEINER, Medical University Vienna, Austria
R. MARTINI, University of Padova, Italy
C. THALHAMMER, University Inselhospital Bern, Switzerland

Animal studies:
B. HIEBL, University of Veterinary Medicine Hannover, Germany
N. NEMETH, University of Debrecen, Hungary
F.Y. ZHUANG, China-Japan Friendship Institute of Clinical Medical Sciences, Beijing, China

Biomedical Engineering:
F. BASSETTO, University of Padua, Italy
F. LIAO, National Center for Nanoscience and Technology, Beijing, China
P. MENU, Université de Lorraine, Nancy, France
G.W. SCHMID-SCHÖNBEIN, University of California, San Diego, USA
J. SEKI, University Osaka, Japan
M. SINGH, Indian Institute of Technology, Madras, India
P. VOGT, Medizinische Hochschule Hannover, Germany

N. ANTONOVA, Bulgarian Academy of Sciences, Sofia, Bulgaria
E. KALIVIOTIS, Cyprus University of Technology, Limassol, Cyprus
A. KOUTSIARIS, Technological Educational Institute of Thessaly, Larisa, Greece
R.N. PITTMAN,  Virginia Commonwealth University, Richmond, USA

Blood Rheology:
J.F. BRUN, Université de Montpellier, France
Y. ISOGAI, Toyama Prefectural University, Japan
H.J. MEISELMAN, University of Southern California, Los Angeles, USA
A. SILVA HERDADE, University of Lisbon, Lisbon, Portugal

C. JUNG, University Düsseldorf, Germany
J.-W PARK, Charité, Berlin, Germany / South-Korea
J.D. PARKER, Sinai Health System University of Toronto, Canada
K. TOTH, University of Pecs, Hungary

Clinical Imaging:
J.P. HONG, University of Ulsan, South Korea
E.M. JUNG, University of Regensburg, Germany
C. STROSZCYNSKI, University of Regensburg, Germany
M. WALDNER, University of Erlangen, Germany
H.-X. XU, Tongji University School of Medicine, Shanghai, China
D. YI, Fudan University, Shanghai, China

Clinical Microcirculation:
V. CERNY, Charles University Prague, Czech Republic
A. COLANTUONI, 'Federico II' University Medical School, Naples, Italy
M. ROSSI, University Hospital of Pisa, Italy

Clinical Studies:
J. CHANG, Stanford University, USA
M. JÜNGER, University of Greifswald, Germany
A. MOMENI, Stanford University, USA
N. TANAHASHI, Tokyo, Japan

S. BALLAS, Thomas Jefferson University, Philadelphia, USA
M.R. HARDEMAN, University of Amsterdam, Netherlands

Human Studies:
R. HORCH, University of Erlangen, Germany
R. ROHRICH, University of Texas Southwestern, Dallas, USA
M. SIMMONDS, Griffith University, Gold Coast, Australia

Internal Medicine:
M. BANERJEE, National Institutes of Health, Bethesda, USA
M. FORNAL, Jagiellonian University, Krakow, Poland
P. LACOLLEY, Broussais Hospital, Paris, France
F. LAGHI PASINI, Università degli Studi Siena, Italy
R.S. ROSENSON, Icahn School of Medicine at Mount Sinai, New York, USA

E. BOUSKELA, University of Rio de Janeiro State, Brasil
H. LENASI, University of Ljubljana, Slovenia
H. LIPOWSKY, Penn State University, USA
R. XIU, Peking Union Medical College, China

Molecular Biology:
J.-H. KUEPPER, Brandenburger-Technische Universität, Germany
J. PIETZSCH, Helmholtz-Zentrum Dresden-Rossendorf, Germany
Ö. YALCIN, Koc University, Istanbul, Turkey

Molecular Medicine:
R. ALIS, Catholic University of Valencia, Spain
S. EGÉE, Université Sorbonne, Paris, France
C. SALDANHA, University of Lisbon, Portugal
J. ZHOU, University of Halifax, Canada

F. FORCONI, University of Southampton, UK
B. WANG, Wuhan, China

W. TO, University of California, USA
S. WOLF, University of Bern, Switzerland
U. WOLF-SCHNURRBUSCH, University of Bern, Switzerland

M.B. YERER-AYCAN, Kaisere, Turkey
B. RIQUELME, Rosario, Argentina

G. NASH, University of Birmingham, UK
A. N. DIKMENOGLI-FALKMARKEN, Hacettepe University, Istanbul, Turkey
M. MANTSKAVA, Beritashvili Institute of Physiology, Tbilisi, Georgia
S. PATUMRAJ, Srinakharinwirot University, Bangkok,Thailand

S. AHMADIZAD, Shahid Beheshti University, Tehran, Iran
S. BRAUNE, Helmholtz Zentrum Geesthacht, Germany

Red Blood Cells:
B. M. COOKE, James Cook University, Cairns, Australia
M. GRAU, Sporthochschule Köln, Germany
W. EL NEMER, Université Paris Diderot, France
M. RAMPLING, Imperial College, London, UK
J.-L. WAUTIER, Université Paris Diderot, France

Stem Cells and Regenerative Medicine:
X. BAI, Medical College of Wisconsin, Milwaukee, USA
A. BLOCKI, The Chinese University of Hong Kong, Hong Kong
S. GEHMERT, University Clinic Basel, Switzerland
V. PAVLOV, Bashir State University, Ufa, Russia
M. RODRIGUES, Stanford University, USA

Trans- and Re-plantation:
E. GEISSLER, University of Regensburg, Germany
R. GIUNTA, LMU München, Germany

Vascular Biology:
T. GORI, University of Mainz, Germany, University of Siena, Italy
M. KLONIZAKIS, Sheffield Hallam University, Sheffield, UK
A. KRÜGER-GENGE, Fraunhofer Institute for Applied Polymer Research, Potsdam, Germany

Vascular Pathology:
A. CHEUNG, University of California, Sacramento, USA
R.P. FRANKE, University of Ulm, Germany
R. KLOPFLEISCH, Freie Universität Berlin, Germany

Wound Healing:
C.E. BUTLER, The University of Texas MD Anderson Cancer Center, Austin, USA
G. GURTNER, Stanford University, USA
B. KUEHLMANN, Stanford University, USA
M. LONGAKER, Stanford University, USA
S. SCHREML, University of Regensburg, Germany
D. WAN, Stanford University, USA


By submitting my article to this journal, I agree to the IOS Press License to Publish: and the IOS Press Privacy Policy:

Authors are requested to submit their manuscript electronically to the journal’s editorial management system.
Note that the manuscript should be uploaded as one file with tables and figures included. This file can be a Word document, a PDF, or a zip file.

Publication fee
From 1 August 2016 there is a publication fee for articles submitted on or after this date, and that are accepted for publication.
Authors pay 300 EUR (340 USD) for an accepted article. Page charges do not apply to feature articles.

Required files for final submissions
After the article has been accepted, the authors should submit the final version as source files, including a word processor file of the text, such as Word or LateX (If using LaTeX, please use the standard article.sty as a style file and also send a PDF version of the LaTeX file).

Colour figures

It is possible to have figures printed in colour, provided the cost of their reproduction is paid for by the author. See Preparation of Manuscripts for the required file formats.

Open Access option
The IOS Press Open Library® offers authors an Open Access (OA) option. By selecting the OA option, the article will be freely available from the moment it is published, also in the pre-press module. In the Open Library® the article processing charges are paid in the form of an Open Access Fee. Authors will receive an Open Access Order Form upon acceptance of their article. Open Access is entirely optional.
See also our website for more information about this option IOS Press Open Library®

This journal publishes all its articles in the IOS Press pre-press module. By publishing articles ahead of print the latest research can be accessed much quicker. The pre-press articles are the uncorrected proof versions of the article and are published online shortly after the proof is created. At the same time, the pre-press articles are indexed by PubMed where they appear as [Epub ahead of print]. Pre-press articles are fully citable by using the DOI number.
As soon as the pre-press article is assigned to an issue, the author corrections will be incorporated and final bibliographic information will be added. The pre-press version will then be replaced by the updated, final version.


Organization of the paper and style of presentation
Manuscripts must be written in English. Authors whose native language is not English are advised to seek the advice of a native English speaker, before submitting their manuscripts.

Peerwith offers a language and copyediting service to all scientists who want to publish their manuscript in scientific peer-reviewed periodicals and books.

Manuscripts should be prepared with wide margins and double spacing throughout, including the abstract, footnotes and references. Every page of the manuscript, including the title page, references, tables, etc., should be numbered. However, in the text no reference should be made to page numbers; if necessary, one may refer to sections. Try to avoid the excessive use of italics and bold face.

Manuscripts should be organized in the following order:

  • Title page
  • Body of text (divided by subheadings)
  • Acknowledgements
  • References
  • Tables
  • Figure captions
  • Figures
  • Headings and subheadings should be numbered and typed on a separate line, without indentation.

    SI units should be used, i.e., the units based on the metre, kilogramme, second, etc.

    Title page
    The title page should provide the following information:

  • Title (should be clear, descriptive and not too long)
  • Name(s) of author(s); please indicate who is the corresponding author
  • Full affiliation(s)
  • Present address of author(s), if different from affiliation
  • Complete address of corresponding author, including tel. no., fax no. and e-mail address
  • Abstract; should be clear, descriptive, self-explanatory and not longer than 200 words, it should also be suitable for publication in abstracting services
  • Keywords
  • Abstract page
    Each paper submitted must be accompanied by an abstract which does not exceed 200 words. It should state concisely the reason for the study, what was done, what was found, what was concluded, and the relevance of the work.
    The abstract for research papers should follow the “structured abstract” format. Section labels should be in bold uppercase letters followed by a colon, and each section will begin on a new line.




    Number as Table 1, Table 2 etc, and refer to all of them in the text.

    Each table should be provided on a separate page of the manuscript. Tables should not be included in the text.

    Each table should have a brief and self-explanatory title.

    Column headings should be brief, but sufficiently explanatory. Standard abbreviations of units of measurement should be added between parentheses.

    Vertical lines should not be used to separate columns. Leave some extra space between the columns instead.

    Any explanations essential to the understanding of the table should be given in footnotes at the bottom of the table.


    Authors are requested to use the Vancouver citation style. Place citations as numbers in square brackets in the text. All publications cited in the text should be presented in a list of references at the end of the manuscript. List the references in the order in which they appear in the text. Only articles published or accepted for publication should be listed in the reference list. Submitted articles can be listed as (author(s), unpublished data). If an article has a DOI, this should be provided after the page number details. Manuscripts will not be considered if they do not conform to the Vancouver citation guidelines.

    References must be listed in Vancouver style:

    [1] Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002;935(1-2):40-6.
    [2] Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA. Medical microbiology. 4th ed. St. Louis: Mosby; 2002.
    [3] Berkow R, Fletcher AJ, editors. The Merck manual of diagnosis and therapy. 16th ed. Rahway (NJ): Merck Research Laboratories; 1992.
    [4] Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGrawHill; 2002. p. 93-113.
    [5] Canadian Cancer Society [homepage on the Internet]. Toronto: The Society; 2006 [updated 2006 May 12; cited 2006 Oct 17]. Available from:
    [6] Tian D, Araki H, Stahl E, Bergelson J, Kreitman M. Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci U S A. In press 2002.
    [7] Fletcher D, Wagstaff CRD. Organisational psychology in elite sport: its emergence, application and future. Psychol Sport Exerc. 2009;10(4):427-34. doi:10.1016/j.psychsport.2009.03.009.


    Footnotes should only be used if absolutely essential. In most cases it is possible to incorporate the information in the text.

    • If used, they should be numbered in the text, indicated by superscript numbers and kept as short as possible.

    Number figures as Fig. 1, Fig. 2, etc and refer to all of them in the text.

    Each figure should be provided on a separate sheet. Figures should not be included in the text.

    Colour figures can be included, provided the cost of their reproduction is paid for by the author.

    For the file formats of the figures please take the following into account:

  • Line art should be have a minimum resolution of 600 dpi, save as EPS or TIFF
  • Grayscales (incl photos) should have a minimum resolution of 300 dpi (no lettering), or 500 dpi (when there is lettering); save as tiff
  • Do not save figures as JPEG, this format may lose information in the process
  • Do not use figures taken from the Internet, the resolution will be too low for printing
  • Do not use colour in your figures if they are to be printed in black & white, as this will reduce the print quality (note that in software often the default is colour, you should change the settings)
  • For figures that should be printed in colour, please send a CMYK encoded EPS or TIFF
  • Figures should be designed with the format of the page of the journal in mind. They should be of such a size as to allow a reduction of 50%.

    On maps and other figures where a scale is needed, use bar scales rather than numerical ones, i.e., do not use scales of the type 1:10,000. This avoids problems if the figures need to be reduced.

    Each figure should have a self-explanatory caption. The captions to all figures should be typed on a separate sheet of the manuscript.

    Photographs are only acceptable if they have good contrast and intensity.


    Copyright of your article
    Authors submitting a manuscript do so on the understanding that they have read and agreed to the terms of the IOS Press Author Copyright Agreement.

    Quoting from other publications
    An author, when quoting from someone else's work or when considering reproducing figures or table from a book or journal article, should make sure that he is not infringing a copyright. Although in general an author may quote from other published works, he should obtain permission from the holder of the copyright if he wishes to make substantial extracts or to reproduce tables, plates or other figures. If the copyright holder is not the author of the quoted or reproduced material, it is recommended that the permission of the author should also be sought. Material in unpublished letters and manuscripts is also protected and must not be published unless permission has been obtained. Submission of a paper will be interpreted as a statement that the author has obtained all the necessary permission. A suitable acknowledgement of any borrowed material must always be made.


    The corresponding author will receive a PDF proof and is asked to check this proof carefully (the publisher will execute a cursory check only). Corrections other than printer's errors, however, should be avoided. Costs arising from such corrections will be charged to the authors.


    How to order reprints, a PDF file, journals, or IOS Press books
    The corresponding author of a contribution to the journal will receive a complimentary PDF Author’s Copy of the article, unless otherwise stated. This PDF copy is watermarked and for personal use only. A free PDF copy will not be provided for conference proceedings and abstract issues. An order form for a PDF file without watermark, reprints or additional journal copies will be provided along with the PDF proof.

    If you wish to order reprints of an earlier published article, please contact the publisher for a quotation. IOS Press, Fax: +31 20 687 0019. Email:

    An author is entitled to 25% discount on IOS Press books. See Author's discount (25%) on all IOS Press book publications.


    Authors of published articles (non-prepress, final articles) will be contacted by Kudos. Kudos is a service that helps researchers maximize the impact and visibility of their research. It allows authors to enrich their articles with lay metadata, add links to related materials and promote their articles through the Kudos system to a wider public. Authors will receive no more than three emails: one invitation and a maximum of two reminders to register for the service and link the published article to their profile. Using and registering for Kudos remains entirely optional. For more information, please have a look at our authors section.


    Would you like some pointers on how to help your research achieve a wider reach and greater impact? Please consult our Promotional Toolkit for Authors for tips.


    Academic Source Complete
    CAB Abstracts
    Chemical Abstracts Service (CAS)
    EBSCO databases
    Google Scholar
    INIST - Institute for Scientific and Technical Information
    Microsoft Academic Search
    SIIC Data Bases
    Ulrich's Periodicals Directory
    Web of Science: Biological Abstracts
    Web of Science: BIOSIS Previews
    Web of Science: Current Contents/Clinical Medicine
    Web of Science: Current Contents®/Life Sciences

    Celebrating 31 years of Clinical Hemorheology and Microcirculation journal

    20 Dec 2012 - Anniversary issue published with review articles on developments in the field ...

    Winner of the A.L. Copley Best Paper Prize 2020:

    Norbert Nemeth


    Prof. Norbert Nemeth MD, PhD, DSc., Full Professor, Head of the Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Hungary (since 2013). Vice-dean for educational affairs of the Faculty of Medicine, University of Debrecen (since 2017). Field of interest: ischemia-reperfusion, microcirculation, experimental and clinical hemorheology, experimental microsurgical models, microsurgical education and training. Former president of the International Society for Experimental Microsurgery (ISEM, 2014-2016), president of the Hungarian Society of Hemorheology (since 2016). Honorary member of the Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SOBRADPEC, 2012). Board member of the International Society for Clinical Hemorheology (since 2008), and of the European Society for Surgical Research (ESSR, Award Committee, 2008-2013). Former president of the Experimental Surgical Session of the Hungarian Surgical Society (2013-2015), vice-president of the Hungarian Society of Laboratory Animal Science (since 2012). Member of the Editorial Board of the journals Microsurgery (since 2006), the Annals of Plastic Surgery (since 2008), the Clinical Hemorheology and Microcirculation (since 2014), the Acta Cirurgica Brasileira (associate editor since 2015), the Frontiers in Physiology (Red Blood Cell Physiology section, review editor since 2018), the Series on Biomechanics (since 2019), and the Journal of Cellular Biotechnology (since 2021).

    The authors received the A.L. Copley Best Paper Prize for their study :
    "Microrheology, microcirculation and structural compensatory mechanisms of a chronic kidney disease rat model. A preliminary study"

    Souleiman Ghanem, Tamas Lesznyak, Laszlo Fazekas, Bence Tanczos, Barbara Barath, Maitham Nasser, Laszlo Horvath, Laszlo Bidiga, Balazs Szabo, Adam Deak,

    Katalin Peto and Norbert Nemeth

    Clinical Hemorheology and Microcirculation 75(1), 2020; 47-56. doi: 10.3233/CH-190763.

    The authors studied two groups of female Sprague-Dawley rats: one subjected to nephrectomy and one sham-operated group where no intervention was made. The study revealed that serum creatinine increased in the nephrectomy group (p = 0.008), accompanied with a decrease of red blood cell count (p = 0.028) and hemoglobin concentration (p = 0.015). Erythrocyte aggregation parameters slightly increased in nephrectomy group, while red blood cell deformability did not show any significant changes. The microcirculation remained intact in the remnant kidney of the nephrectomy group. However, in comparison with the sham-operated group, the diameter of glomeruli increased significantly (p < 0.01). The authors concluded that erythrocyte mass was influenced more than micro-rheological properties in this model. The main compensation mechanism was rather structural than at microcirculatory level.

    Winner of the A.L. Copley Best Paper Prize 2019:

    Francesco Misiti

    Curriculum Vitae

    Simone Dinarelli, Marco Girasole and Francesco Misiti "Amyloid β peptide affects erythrocyte morphology: Role of intracellular signaling pathways" Clinical Hemorheology and Microcirculation 71(4), 2019, 437-449. doi: 10.3233/CH-199007.

    "S. Dinarelli and colleagues received the Prize for their prospective study about the relationship between amyloid peptide and erythrocyte morphology and the role of intracellular pathways. The study revealed that amyloid ß treatment accelerated the occurrence of morphological and biochemical aging markers in human red blood cells and influenced the cell metabolism. Biochemical data demonstrated that contemporaneously to morphological alterations, Aβ triggers: (i) metabolic alterations and (ii) a complex signaling pathway involving caspase 3, protein kinase C and nitric oxide derived metabolites. The study provides an insight how amyloid ß treatment of RBC induced changes in specific cell signalling events and/or metabolic pathways, in turns affecting the membrane-cytoskeleton interaction and the membrane integrity." [ F. Jung, P. Connes, C. Lehmann, A.L. Copley Best Paper Prize 2019, Clin Hemorheol Microcirc 75(1) (2020), doi: 10.3233/CH-209100]

    Winner of the A.L. Copley Best Paper Prize 2018:

    David N. Naumann

    Curriculum Vitae

    David Naumann is an honorary clinical lecturer at the University of Birmingham, and honorary research fellow at Imperial College London. He graduated from medical school at the University of Cambridge in 2006 and joined the Royal College of Surgeons in 2008. His PhD research was undertaken at the University of Birmingham, where he investigated early microcirculatory dysfunction following traumatic haemorrhagic shock. He is currently a member of the faculty for the Trauma Sciences MSc at the University of Birmingham, and works as a surgical registrar in the West Midlands, as part of the UK Defence Medical Services. His ongoing research interests include trauma immunology, and the response of the endothelium, circulating immune cells and microcirculation to trauma and haemorrhagic shock.

    "Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: A prospective observational study" D.N. Naumann, J. Hazeldine, J. Bishop, M.J. Midwinter, P. Harrison, G. Nash and S.D. Hutchings. Clinical Hemorheology and Microcirculation 71(1), 2019, 71-82. doi: 10.3233/CH-180397.

    The authors tested the hypothesis that changes in plasma viscosity affect microcirculatory flow following injury and haemorrhagic shock. There is evidence from preclinical studies (particularly small animal models) that increased plasma viscosity may improve flow, but this had not yet been tested in a clinical setting. This is particularly important because viscosity may be a physical property of importance when designing and selecting resuscitation fluids. The authors were the first to compare microcirculatory flow parameters (using sublingual incident dark field video-microscopy) with plasma viscosity (measured using a Wells-Brookfield cone and plate micro-viscometer) in a cohort of patients admitted to hospital following major trauma. They found no evidence of improved microcirculatory flow in the presence of higher viscosity, which seems to contrast with evidence from animal studies. These findings cast some doubt on the translatability of animal studies to more complex clinical scenarios, and suggest that further investigations are required to determine whether the viscosity of resuscitation fluid is indeed a factor of relevance in clinical practice.

    Winner of the A.L. Copley Best Paper Prize 2017:

    Zsolt Marton, MD

    Curriculum Vitae

    Zsolt Marton works as an assistant professor at the University of Pecs Medical School. He is a specialist in internal medicine, cardiology and intensive care. He graduated at the Medical University of Pecs, Hungary in 1999. As the head of the Intensive Care Unit of the 1st Department of Medicine, University of Pecs he takes part in the care of critically ill and cardiology patients and manages the activities of the ICU. He participates in the education of both medical students and PhD trainees. His research initially focused on the effect of free radicals on hemorheologic parameters, methodological aspects of hemorheology, then mainly on the relation of hemodynamic and hemorheologic parameters in the field of cardiology and intensive care. His special interest is to investigate the rheological parameters and microcirculation in seriously altered hemodynamic state. He is a member of the Hungarian Society of Hemorheology, Hungarian Society of Cardiology and Hungarian Society of Anesthesiology and Intensive Therapy.

    "The relationship between hemorheological parameters and mortality in critically ill patients with and without sepsis" K. Totsimon, K. Biro, Z.E. Szabo, K. Toth, P. Kenyeres and Z. Marton Clinical Hemorheology and Microcirculation 65(2), 2017, 119-129. doi: 10.3233/CH-16136.

    The authors investigated the prognostic role of hemorheological parameters in critical ill patients. They compared the changes of rheological variables to hemodynamic alterations and to well-known prognostic scores. Patients treated on intensive care unit with different non-surgical diseases were studied. Routine laboratory parameters and prognostic scores (APACHE, SAPS) were determined and hemorheological variables (hematocrit, plasma and whole blood viscosity, red blood cell aggregation and deformability) were measured an different time points. Whole blood viscosity and red blood cell deformability were found lower, red blood cell aggregation higher in septic than in nonseptic patients. In nonseptic patients whole blood viscosity, red blood cell aggregation were higher in nonsurvivors compared to survivors. Worsening of red blood cell deformability predicted higher mortality. Their findings prove that rheological parameters (especially red blood cell aggregation deformability) could predict mortality in severely ill patients and they may add prognostic information over the routine ICU scores.

    Winner of the A.L. Copley Best Paper Prize 2016:

    Thomas Neumann, MD


    Curriculum Vitae

    T. Neumann, M. Baertschi, W. Vilser, S. Drinda, M. Franz, A. Bruckmann, G. Wolf and C. Jung
    “Retinal vessel regulation at high altitudes”
    Clin Hemorheol Microcirc 63 (2016), 281-292. doi: 10.3233/CH-162041.

    The authors set up a two parts study where 1) healthy individuals were exposed to a simulated altitude of 5500 meters and 2) a second group of healthy individuals were brought to a mountain station at an altitude of 3000 meters. In the second part of the study, individuals were also treated with a dual endothelin (ET) receptor antagonist that binds the two ET receptor subtypes, ETA and ETB. The authors investigated the retinal vessel diameter, response to flicker light, retinal oxygen saturation and retinal venous pressure in the different experimental conditions. Both hypoxic exposures caused an increase of retinal arterial and venous diameters and a decrease of the arterial and venous response to flicker light. In the second part of the study, retinal venous pressure increased in 6 individuals after ascent to 3000 meters and normalized after dual ET receptor antagonist. This finding clearly shows that hypoxia may disturb retinal vascular reactivity in apparently healthy individuals and highlight the effects of blocking ET receptors in such an environmental situation.