Share this news

Patients with Parkinson’s Disease Face Unique “Hidden Sorrows” Related to the COVID-19 Pandemic

Experts writing in the Journal of Parkinson’s Disease discuss potentially grave consequences for Parkinson’s disease patients related to social distancing, but also opportunities like new avenues for research and initiatives that may offer positive help and support

April 3, 2020
Amsterdam, NL – While much attention has focused on the potential for severe respiratory complications and unfavorable outcomes from the COVID-19 pandemic among patients with Parkinson’s disease (PD), the impact extends beyond these threats. Social distancing requires flexible adaptation to new circumstances, resilience, and a reduction in physical activities, which may be more difficult for patients with PD.

Writing in the Journal of Parkinson’s Disease, Rick C. Helmich, MD, PhD, and Bastiaan R. Bloem, MD, PhD, of the Radboud University Medical Centre; Donders Institute for Brain, Cognition and Behavior; Department of Neurology; Centre of Expertise for Parkinson & Movement Disorders; Nijmegen, the Netherlands say, “The pathophysiology of PD puts patients at an increased risk of chronic stress, and a further worsening of this may well be one of the ‘hidden sorrows’ of the COVID-19 pandemic. Increased psychological stress can worsen motor symptoms, while reducing the efficacy of dopaminergic medication.” They also note that there is some evidence that stress can trigger latent PD.

Resilience, or the ability to maintain or quickly recover mental health during and after times of adversity, can protect against the detrimental effects of stress. Dr. Helmich and Dr. Bloem note that the current crisis offers opportunities to see who copes best under the current circumstances, in order to understand the factors that contribute to resilience in PD patients. Mindfulness-based interventions can reduce stress, and they see opportunities for web-based solutions to help reduce anxiety and depression, and also to reduce social isolation.

Another hidden consequence of the pandemic is a marked reduction in physical activities. Recent evidence has shown that physical exercise may reduce symptom progression in PD. Loss of aerobic exercise may lead to a worsening of motor symptoms in PD and may contribute further to psychological stress. “A hopeful consequence of the current crisis has been the emergence of web-based exercise initiatives such as online singing, exercise, or dancing classes for PD patients,” note the authors. “Self-management strategies that reduce stress, increase coping, or increase physical exercise will play an increasing role in the treatment of PD.”

The crisis offers emerging opportunities for PD research, as well. The authors observe that the COVID-19 pandemic is an external stressor that is aligned in time for large groups of people. This provides a unique opportunity for researchers to test how the pandemic influences the course of PD in existing groups of patients enrolled in research studies. It also allows researchers to study what factors increase resilience in PD. “Deleterious as the current crisis may be, it will hopefully also bring about some long-term positive outcomes for the many people living with PD worldwide,” observe Dr. Helmich and Dr. Bloem.

PD is a slowly progressive disorder that affects movement, muscle control and balance. It is the second most common age-related neurodegenerative disorder affecting about 3% of the population by the age of 65 and up to 5% of individuals over 85 years of age.

###

NOTES FOR EDITORS:
Full open access commentary: “The impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities” by Rick C. Helmich, MD, PhD and Bastiaan R. Bloem, MD, PhD (DOI: 10.3233/JPD-xxxxxxx) published in the Journal of Parkinson’s Disease, Volume 10, Issue 2 (April 2020) by IOS Press. This article is openly available at: content.iospress.com/articles/journal-of-parkinsons-disease/jpd202038.

Bastiaan R. Bloem, MD, PhD, is Co-Editor-in-Chief of the Journal of Parkinson’s Disease.

Contact
For additional information contact Diana Murray, IOS Press (+1 718-640-5678 or d.murray@iospress.com). Journalists wishing to interview the study’s authors should contact Rick Helmich (rick.helmich@radboudumc.nl) or Bas Bloem (bas.bloem@radboudumc.nl).

About Journal of Parkinson’s Disease
Celebrating its 10th anniversary in 2020, the Journal of Parkinson’s Disease (JPD) is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that will expedite our fundamental understanding and improve treatment of Parkinson’s disease. The journal is international and multidisciplinary and aims to promote progress in the epidemiology, etiology, genetics, molecular correlates, pathogenesis, pharmacology, psychology, diagnosis and treatment of Parkinson’s disease. JPD publishes research reports, reviews, short communications, and letters-to-the-editor and offers very rapid publication and an affordable open access option. JPD has a Journal Impact Factor of 3.698 according to Journal Citation Reports (Web of Science Group, 2019) and is published by IOS Press. journalofparkinsonsdisease.com

About IOS Press
IOS Press is headquartered in Amsterdam with satellite offices in the USA, Germany, India and China and serves the information needs of scientific and medical communities worldwide. IOS Press now publishes more than 80 international peer-reviewed journals and about 75 book titles each year on subjects ranging from computer science, artificial intelligence, and engineering to medicine, neuroscience, and cancer research. iospress.com