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New Evidence: Effects of Huntington’s Disease Mutation May Begin in Childhood

The neurodevelopmental hypothesis of Huntington’s disease (HD) suggests its origins are rooted in childhood when the mutant gene that causes HD begins to affect both brain and body growth and development, reports JHD

January 6, 2021
Amsterdam, NL – There is growing evidence to support the hypothesis that there is a neurodevelopmental component to the late-onset neurodegeneration occurring in the brain of huntingtin gene (HTT gene) mutation carriers, and that this increased susceptibility to brain cell death begins during childhood. Experts discuss the evidence that the HTT gene mutation affects brain and body growth based on a unique study of children at risk for HD, the Kids-HD study, in a review paper and accompanying research article published in the Journal of Huntington’s Disease.

The classic concept is that Huntington’s disease is caused by toxic mutant huntingtin (mHTT) acting over time on mature brain cells. However, there is growing evidence for an alternative theory in which mHTT has an effect on brain development and that this altered development plays a vital role in the later degenerative process. This theory is based on the notion that wild-type huntingtin (HTT) function plays a role in normal brain development.

“Although the gene was discovered in 1993, we still don’t have a good understanding of what causes HD – how does the mutant gene cause brain cells to become ‘sick’ then die?” noted lead investigator Peg C. Nopoulos, MD, Department of Psychiatry, Department of Pediatrics, and Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA. “The neurodevelopmental hypothesis is a relatively new way of thinking about the disease and can help focus research efforts in a new direction. This review and the accompanying study are important in reshaping our ideas about how we view the nature and timing of preventive treatment for HD and the factors that contribute to disease.”

The neurodevelopmental hypothesis of HD posits that the disease-causing gene mutation affects development of a specific region or specific brain circuit. These cells are abnormal in their growth; however, they are compensated for early in life. Therefore, despite abnormal development, there are no overt symptoms. The abnormally developed cells remain in a “mutant steady state.” These cells are then vulnerable to dysfunction and degeneration later in life when they are subjected to stresses and strains, either normal (programmed synaptic elimination during puberty or through the aging process) or pathological (toxic effects of mHTT). In the end, the disease pathology results in neural degeneration with its accompanying cognitive and motor deficits.

Caption: Theories of the etiology of Huntington’s disease (credit: JHD)

The two papers focus on the most recent findings from Kids-HD, a unique brain imaging study of children aged six to 18 years old at risk for HD because they have a parent or grandparent with HD. The review discusses the effects of mHTT on brain development and the study evaluates the effect of mHTT on body development.

According to the authors, there is evidence in children as young as 6 who carry a mutation in the HTT gene, that production of mHTT alters the growth and development of the striatum and related circuitry. The gene contains a sequence of three DNA bases – cytosine-adenine-guanine (CAG) – repeated multiple times. The developmental changes appear to be influenced by the CAG repeat length and occur well before onset of symptoms of the disease. Deficits may then be compensated for by increased activity in other brain circuits, particularly those involving the cerebellum, and are manifest only when compensatory systems are no longer working.

The body development analysis used data from the 186 children in the Kids-HD study. Investigators applied simple measures of growth – height, weight, and the combined BMI measure – to compare changes in two groups – those who carried the CAG repeat expansion mutation in the HTT gene and those who did not.

Around puberty the study began to show an altered trajectory of growth in HTT gene mutation carriers. The pace at which their BMI increased slowed over time so that at by about 17 years old, that group had substantially lower BMI than the group without the gene mutation. Boys with the gene mutation tended to be taller than the control group, but with lower weight; girls with the gene mutation tended to be around the same height, but lower in weight.

Importantly, although the gene mutation carriers were roughly 30 years from the expected time of onset of the disease, the mutant HTT gene had already affected their growth and development. This work is important because it suggests that the mutation is altering the body even before the onset of neurological disease in midlife.

Gene therapy trials are currently underway to evaluate the effectiveness of drugs to slow disease progression in affected individuals, and future trials will ultimately aim to prevent disease onset by delivery of gene therapy to gene mutation carriers – those with mHTT, but no symptoms.

“Gene therapy trials are finally here. However, interfering with a gene responsible for brain development early in life must be done with an abundance of caution,” commented Dr. Nopoulos. “Understanding how mHTT affects brain development is vital in the context of planning disease prevention therapies.”

HD is a fatal genetic neurodegenerative disease that causes the progressive breakdown of nerve cells in the brain. An estimated 250,000 people in the United States are either diagnosed with, or at risk for, the disease. Symptoms include personality changes, mood swings and depression, forgetfulness and impaired judgment, unsteady gait, and involuntary movements (chorea). Every child of an HD parent has a 50% chance of inheriting the gene. Patients usually survive 10–20 years after diagnosis.

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NOTES FOR EDITORS
Full open access review article: “The Neurodevelopmental Hypothesis of Huntington’s Disease” by Ellen van der Plas, Jordan Schultz, and Peg C. Nopoulos (doi.org/10.3233/JHD-200394), in the Journal of Huntington’s Disease, Volume 9, Issue 3 published by IOS Press. The article is openly available at: content.iospress.com/articles/journal-of-huntingtons-disease/jhd200394

This article was supported by the CHDI Foundation and National Institute of Neurological Disorders and Stroke (NINDS) Grant #NS055903.

Full open access research article: “Developmental Trajectory of Height, Weight, and BMI in Children and Adolescents at Risk for Huntington’s Disease: Effect of mHTT on Growth” by Alexander Tereshchenko, Ellen van der Plas, Kathy Mathews, Eric Epping, Amy Conrad, Doug Langbehn, and Peg C. Nopoulos (doi.org/10.3233/JHD-200407), in the Journal of Huntington’s Disease, Volume 9, Issue 3 published by IOS Press. The article is openly available at: content.iospress.com/articles/journal-of-huntingtons-disease/jhd200407.

This study was supported by grants from the National Institute for Neurologic Disorders and Stroke (NINDS), 5R01NS055903; the CHDI Foundation; the Huntington Disease Society of America; the University of Iowa Huntington Disease Center of Excellence; and the University of Iowa Clinical and Translational Science Award (UL1 TR002537). This work was conducted on an MRI instrument funded by 1S10OD025025-01.

Contact
Diana Murray, IOS Press, can be contacted (+1 7186405678 or d.murray@iospress.com) for additional information. Journalists who wish to interview the authors should contact Peg C. Nopoulos, MD (peggy-nopoulos@uiowa.edu).

About the Journal of Huntington’s Disease
The Journal of Huntington’s Disease (JHD) is an international multidisciplinary journal to facilitate progress in understanding the genetics, molecular correlates, pathogenesis, pharmacology, diagnosis and treatment of Huntington’s disease and related disorders. The journal publishes research reports, reviews, short communications, letters-to-the-editor, and will consider research that has negative findings. JHD is dedicated to providing an open forum for original research in basic science, translational research, and clinical medicine that will expedite our fundamental understanding and improve treatment of Huntington’s disease and related disorders. iospress.com/journal-of-huntingtons-disease

About IOS Press
IOS Press is headquartered in Amsterdam with satellite offices in the USA, Germany, India and China and serves the information needs of scientific and medical communities worldwide. IOS Press now publishes more than 90 international peer-reviewed journals and about 65 book titles each year on subjects ranging from computer science, artificial intelligence, and engineering to medicine, neuroscience, and cancer research. iospress.com