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Air Pollution Poses Risk to Thinking Skills in Later Life, a Study Says

February 8, 2021
Edinburgh, UK – Exposure to air pollution in childhood is linked to a decline in thinking skills in later life, a study published in the Journal of Alzheimer's Disease suggests. A greater exposure to air pollution at the very start of life was associated with a detrimental effect on people’s cognitive skills up to 60 years later, the research found.

Researchers at the University of Edinburgh tested the general intelligence of more than 500 people aged approximately 70 years using a test they had all completed at the age of 11 years. The participants then repeated the same test at the ages of 76 and 79 years. A record of where each person had lived throughout their life was used to estimate the level of air pollution they had experienced in their early years.

The team used statistical models to analyse the relationship between a person’s exposure to air pollution and their thinking skills in later life. They also considered lifestyle factors, such as socio-economic status and smoking. Findings showed exposure to air pollution in childhood had a small but detectable association with worse cognitive change between the ages of 11 and 70 years.

This study shows it is possible to estimate historical air pollution and explore how this relates to cognitive ability throughout life, researchers say.

Dr Tom Russ, Director of the Alzheimer Scotland Dementia Research Centre at the University of Edinburgh, said: “For the first time we have shown the effect that exposure to air pollution very early in life could have on the brain many decades later. This is the first step towards understanding the harmful effects of air pollution on the brain and could help reduce the risk of dementia for future generations.”

Researchers say until now it has not been possible to explore the impact of early exposure to air pollution on thinking skills in later life because of a lack of data on air pollution levels before the 1990s when routine monitoring began.

For this study researchers used a model called the EMEP4UK atmospheric chemistry transport model to determine pollution levels  known as historical fine particulate matter (PM2.5) concentrations  for the years 1935, 1950, 1970, 1980, and 1990. They combined these historical findings with contemporary modelled data from 2001 to estimate life course exposure.

The participants were part of the Lothian Birth Cohort 1936 study, a group of individuals who were born in 1936 and took part in the Scottish Mental Survey of 1947. Since 1999, researchers have been working with the Lothian Birth Cohorts to chart how a person’s thinking power changes over their lifetime.


Full open access study: “Life Course Air Pollution Exposure and Cognitive Decline: Modelled Historical Air Pollution Data and the Lothian Birth Cohort 1936” by Tom C. Russ, Mark P.C. Cherrie, Chris Dibben, Sam Tomlinson, Stefan Reis, Ulrike Dragosits, Massimo ieno, Rachel Beck, Ed Carnell, Niamh K. Shortt, Graciela Muniz-Terrera, Paul Redmond, Adele M. Taylor, Tom Clemens, Martie van Tongeren, Raymond M. Agius, John M. Starr, Ian J. Deary, and Jamie R. Pearce (DOI:10.3233/JAD-200910), published in the Journal of Alzheimer’s Disease, Volume 79, Issue 3 (February 2021). The article is freely available at: This study will also appear in the upcoming book Air Pollution and Alzheimer’s Disease (details, when available, can be found here).

The study – funded by the Natural Environment Research Council NERC – was carried out in partnership with the UK Centre for Ecology & Hydrology (UKCEH) and the University of Manchester. It was also supported by Age UK (Disconnected Mind project) and Alzheimer Scotland.

For further information, please contact: Joanne Morrison, Press and PR Office, University of Edinburgh (+44 1316514266,

About the Journal of Alzheimer’s Disease
Now in its 24th year of publication, the Journal of Alzheimer’s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment, and psychology of Alzheimer’s disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. Groundbreaking research that has appeared in the journal includes novel therapeutic targets, mechanisms of disease, and clinical trial outcomes. JAD has a Journal Impact Factor of 3.909 according to Journal Citation Reports (Clarivate, 2020). The journal is published by IOS Press.