Aerobic Exercise Training Linked to Enhanced Brain Function in Adults at Risk for Alzheimer’s Disease
Regular aerobic exercise may decrease the likelihood of developing Alzheimer's disease, or slow its progression, in adults who are at higher risk, say scientists in a special issue of Brain Plasticity
February 3, 2020
Amsterdam, NL – Individuals at risk for Alzheimer's disease (AD) because of family history or genetic predisposition who engaged in six months of aerobic exercise training improved their brain glucose metabolism and higher-order thinking abilities (e.g., planning and mental flexibility) called executive function; these improvements occurred in conjunction with increased cardiorespiratory fitness. The results of this study are published in a special issue of Brain Plasticity devoted to Exercise and Cognition.
Drugs currently available to treat AD have limited therapeutic capacity. At a time when both the human and monetary costs of the disease are projected to rise dramatically in the coming decades, there is a critical need to provide individuals with readily-deployable strategies that can decrease the likelihood of acquiring the disease or slow its progression. Researchers therefore investigated whether exercise training in asymptomatic individuals harboring risk for AD improves markers associated with AD.
“This study is a significant step toward developing an exercise prescription that protects the brain against AD, even among people who were previously sedentary,” explained lead investigator Ozioma C. Okonkwo, PhD, of the Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health.
The study investigated 23 cognitively normal, relatively young older adults with a family history or genetic risk for AD. All patients had a sedentary lifestyle. They underwent a battery of assessments, including cardiorespiratory fitness testing, measurement of daily physical activity, brain glucose metabolism imaging (a measure of neuronal health), and cognitive function tests.
Half of the participants were randomly assigned to receive information about maintaining an active lifestyle but no further intervention. The other half participated in a moderate intensity treadmill training program with a personal trainer, three times per week for 26 weeks.
Compared to the participants maintaining their usual level of physical activity, individuals assigned to the active training program improved their cardiorespiratory fitness, spent less time sedentary after the training program ended, and performed better on cognitive tests of executive functioning (but not episodic memory). Executive function, an aspect of cognition that is known to decline with the progression of AD, comprises the mental processes enabling individuals to plan, focus attention, remember instructions, and juggle multiple tasks successfully. The participants’ improved cardiorespiratory fitness was associated with increased brain glucose metabolism in the posterior cingulate cortex, an area of the brain linked to AD.
“This research shows that a lifestyle behavior – regular aerobic exercise – can potentially enhance brain and cognitive functions that are particularly sensitive to the disease. The findings are especially relevant to individuals who are at a higher risk due to family history or genetic predisposition,” noted Dr. Okonkwo. The lead author on the study, Max Gaitán, MEd, of the Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, remarked that “an important next step would be to conduct a larger, more definitive, study. If these findings are replicated, they would have a tremendous impact on quality of later life, providing individuals with more years of independent living, active engagement with loved ones, and building memories.”
NOTES FOR EDITORS
Special Issue: Exercise and Cognition
Guest Editors: Henriette van Praag and Ozioma Okonkwo
Brain Plasticity, Volume 5, Issue 1
Open access content at: content.iospress.com/journals/brain-plasticity/5/1
Featured article: “Brain Glucose Metabolism, Cognition, and Cardiorespiratory Fitness Following Exercise Training in Adults at Risk for Alzheimer’s Disease” by Julian M. Gaitán, Elizabeth A. Boots, Ryan J. Dougherty, Jennifer M. Oh, Yue Ma, Dorothy F. Edwards, Bradley T. Christian, Dane B. Cook, and Ozioma C. Okonkwo (DOI 10.3233/BPL-190093).
Full open access study: content.iospress.com/articles/brain-plasticity/bpl190093.
For additional information, contact Diana Murray, IOS Press (+1 718-640-5678 or firstname.lastname@example.org). To reach the authors of this study, please contact Emily Kumlien (+1 608 265 8199 or email@example.com). For information about the special issue, contact Dr. Ozioma Okonkwo (firstname.lastname@example.org) or Dr. Henriette van Praag (email@example.com).
About Brain Plasticity
Brain Plasticity publishes peer-reviewed original articles, reviews, and short communications on all aspects of neurogenesis, gliogenesis, and synaptic plasticity, from development to the adult. This includes research articles or reviews on modifications to neural circuits in the developing and adult brain, whether by learning or physical activity, spine formation, changes in neural structure, changes in neural networks, new cell division, as well as response of the CNS to experimental injuries, neurodevelopmental and neurodegenerative disorders. Papers published in the open access journal adopt fresh conceptual approaches on specification and function at the molecular and cellular levels, neural circuits, systems and behavioral levels are encouraged. iospress.com/brain-plasticity
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