Epigenetic Markers

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Editor
Widschwendter, M.
Pub. date
March 2007
Pages
138
Binding
softcover
Book edition of
ISBN print
978-1-58603-722-2
Subject
Cancer Research, Medicine & Health
€138 / US$200 Excl. VAT
Order Epigenetic Markers ISBN @ €138.00

DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA’s four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off. DNA methylation patterns differ dramatically between healthy and diseased tissue and thereby can serve as biomarkers, opening a window into earlier detection of disease.
Editor Martin Widschwendter (Institute for Women’s Health, University College London) emphasizes that, “The concept of early detection of tumours before they spread and become incurable, represents one of the most important challenges in reducing the impact of the growing burden of cancer worldwide… Altered patterns of DNA methylation can be detected with high sensitivity, potentially providing us with diagnostic, prognostic and predictive information, and can be reversed by appropriate drug treatment. These possibilities make cancer epigenetics a most exciting field of current translational research.”
This book contains ten articles that explore the details and challenges of cancer epigenetics.