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Targeting Alpha-Synuclein in the Gut May Slow Down Parkinson’s Disease

November 13, 2019 - Amsterdam, NL – Aggregates of the protein alpha-synuclein arising in the gut may play a key role in the development of Parkinson's disease (PD). Investigators are testing the hypothesis that by targeting the enteric nervous system with a compound that can inhibit the intracellular aggregation of alpha-synuclein, they can restore enteric functioning in the short term, and possibly slow the progressive deterioration of the central nervous system in the long term. They review results to date in the Journal of Parkinson's Disease.

November 13, 2019

Researchers Develop a New Home-Based App to Better Monitor Parkinson’s Disease Motor Symptoms

November 12, 2019 - Amsterdam, NL – In order to optimally treat motor symptoms in patients with Parkinson's disease (PD), it is necessary to have a good understanding of their severity and daily fluctuations. A report in the Journal of Parkinson's Disease describes how a new app, SleepFit, could be a useful tool in routine clinical practice to monitor motor symptoms and facilitate specific symptom-oriented follow-up. The researchers also determined that information obtained prospectively in real time from the user-friendly app can differ from data gathered retrospectively from patient interviews.

November 12, 2019

Nusinersen Improves Motor Function in Adults with Spinal Muscular Atrophy

November 11, 2019 - Amsterdam, NL – A study published in the Journal of Neuromuscular Diseases presents the first evidence of mild improvement or stabilization of motor and respiratory function in adults with spinal muscular atrophy type 3 (SMA3) treated with Nusinersen, which was the case even in patients who have had the disease for 20 years or more. These findings prove the efficacy of Nusinersen beyond types and age groups, paving the way for adult treatment.

November 11, 2019

What Do We Know About the Gut Microbiota in Parkinson’s Disease?

November 11, 2019 - Amsterdam, NL – Since the discovery that the gut microbiome may play a role in the development of Parkinson's disease (PD), this fresh scientific approach has produced varying results. In this review published in the Journal of Parkinson's Disease scientists compare results of current research and provide recommendations to increase the comparability and utility of these studies with a view towards improving patient outcomes.

November 11, 2019