Nottingham scientists uncover new clues for early diagnosis of Alzheimer’s

February 7, 2012 - Scientists in Nottingham have found abnormal levels of seven different proteins in spinal fluid could act as markers for detecting Alzheimer’s disease. The study, which was part-funded by Alzheimer’s Research UK, the UK’s leading dementia research charity, could lead to the development of a new test to detect the disease in its early stages. More...

February 7, 2012

Shoulder Pain from Using your iPad? Don’t Use It on Your Lap

Recommendations for Tablet Computer Use Published in WORK: A Journal of Prevention, Assessment, and Rehabilitation

January 27, 2012 - The sudden popularity of tablet computers such as the Apple iPad® has not allowed for the development of guidelines to optimize users’ comfort and well-being. In a new study published in WORK: A Journal of Prevention, Assessment, and Rehabilitation, researchers from Harvard School of Public Health, Microsoft Corporation, and Brigham and Women’s Hospital report that head and neck posture during tablet computer use can be improved by placing the tablet higher to avoid low gaze angles, and through the use of a case that provides optimal viewing angles. More...

January 27, 2012

Scientists Report First Step in Strategy for Cell Replacement Therapy in Parkinson’s Disease

Research Published in the Journal of Parkinson's Disease

January 25, 2012 - Induced pluripotent stem cells (iPSC) are a promising avenue for cell replacement therapy in neurologic diseases. For example, mouse and human iPSCs have been used to generate dopaminergic (DA) neurons that improve symptoms in rat Parkinson’s disease models. Reporting in the current issue of the Journal of Parkinson’s Disease, a group of scientists from Japan evaluated the growth, differentiation, and function of human-derived iPSC-derived neural progenitor cells (NPCs) in a primate model, elucidating their therapeutic potential. More...

January 25, 2012

New Research Reveals How α-Synuclein Interacts with Cell Membranes in Parkinson’s Disease

Report Published in the Journal of Parkinson's Disease

January 19, 2012 - The accumulation of α-synuclein, a small, negatively charged protein, in neural cells, is one of the hallmarks of Parkinson’s disease. It has been suggested that oligomeric α-synuclein causes membranes to become permeable, or to form channels on the outer cell membrane. Now, a group of scientists from Sweden has found a way to reliably replicate α-synuclein aggregation on cell membranes to investigate how different forms of α-synuclein interact with membranes under different conditions and to learn if any of the α-synuclein species can penetrate these membranes. Their results are published in the current issue of the Journal of Parkinson’s Disease. More...

January 19, 2012