Restorative Neurology and Neuroscience

Restorative Neurology and Neuroscience

impact factor 2014 4.179
ISSN print
0922-6028
ISSN online
1878-3627
Volume
32; 6 issues
Status
Last issue (32:5) online on 07 October 2014
Next issue
32:6 scheduled for December 2014
Back volumes
1-31
Subject
Biochemistry, Medicine & Health, Neurosciences
Institutional subscription for 2014 €1090 / US$1450 Excluding VAT
Subscription Rates Free Sample Copy
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This interdisciplinary journal publishes papers relating the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. Experiments on un-anesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind peer review to editorial board members or outside reviewers.

Restorative Neurology and Neuroscience is a member of Neuroscience Peer Review Consortium.

Editor-in-Chief

Bernhard A. Sabel, PhD
Institute of Medical Psychology
Otto-v.-Guericke University of Magdeburg
Leipzigerstrasse 44
39120 Magdeburg
Germany
Tel.: +49 391 672 1800
Fax:+49 391 672 1803
Email: rnn@med.ovgu.de

Managing Editor

Sylvia Prilloff, PhD
Email: editor-rnn@med.ovgu.de

Editorial Assistant

Steffi Matzke

Founding Editor

Donald G. Stein

Reviewing Editors

Doychin N. Angelov, University of Cologne, Cologne, Germany
William Freed, NIDA, Baltimore, USA
Lutz Jäncke, University Zurich, Zurich, Switzerland 
Josef Rauschecker, Georgetown University, Washington, USA
Paolo Maria Rossini, Catholic University of Rome , Rome, Italy
Donald G. Stein, Emory University, Atlanta, USA

 

 

Associate Editors

Zubair Ahmed, University of Birmingham, Birmingham, United Kingdom
Jane B. Allendorfer, University of Alabama at Birmingham, Birmingham, USA
Eckart Altenmüller, HMTM-Hannover, Hannover, Germany
Amir Amedi, The Hebrew University of Jerusalem, Jerusalem, Israel
Patrick Anderson, University College London, London, United Kingdom
Andrea Antal, University Göttingen, Göttingen, Germany
Kristyn A. Bates, The University of Western Australia, Perth, Australia
Eric Beaumont, University Montréal, Montréal, Canada
Christian Behl, Johannes Gutenberg University Mainz, Mainz, Germany
Jorge A. Bergado, CIREN , Havana, Cuba
Michael Borich, University of British Columbia , Vancouver, Canada
Daniele Bottai, University of Milan, Milan, Italy
Lara Boyd, University of British Columbia, Vancouver, Canada
Stephan Brandt, Charité, Berlin, Germany
Barbara S. Bregman, Georgetown University, Washington D.C., USA
Jacqueline Bresnahan, Ohio State University Medical Center, Columbus, USA
Ross Bullock, Virginia Commonwealth University, Richmond, USA
Merih Cetinkaya, Uludag University, Bursa, Turkey
Neelima B. Chauhan, Jesse Brown VA Medical Center, University of Illinois at Chigaco, Chicago, USA
Benjamin Clemens, RWTH Aachen University Hospital, Aachen, Germany
Leonardo Cohen, NINDS-NIH , Bethesda, USA
Branch Coslett, University of Pennsylvania, Philadelphia, USA
Koen Cuypers, REVAL, Hasselt University, Diepenbeek, Belgium
Volker Dietz, University Hospital Balgrist, Zürich, Switzerland
Máté D. Döbrössy, University Hospital Freiburg, Freiburg, Germany
Gary Dunbar, Central Michigan University, Michigan, USA
Dominique Durand, Case Western Reserve University, Cleveland, USA
Michael Fehlings, Toronto Western Hospital, Toronto, Canada
Florinda Ferreri, University Campus Biomedico, Rome, Italy
Seth Finklestein, Biotrofix Inc., Nedham, USA
Herta Flor, Central Institute of Mental Health, Mannheim, Germany
Karin Forsberg Nilsson, Uppsala University, Uppsala, Sweden
Richard Frackowiak, CHUV University Hospital, London, UK
Felipe Fregni, Harvard Medical School , Boston, USA
Augusto Fusco, IRCCS Fondazione Santa Lucia, Rome, Italy
Afsaneh Gaillard, Université de Poitiers , Poitiers, France
Diana García del Barco-Herrera, Center for Genetic Engineering and Biotechnology Pharmaceutical Division, La Habana, Cuba
Alfredo Gorio, University of Milan, Milano, Italy
Sherifa Hamed, Assiut University Hospital , Assiut, Egypt
Roy Hamilton, University of Pennsylvania, Philadelphia, USA
Alan Harvey, University of Western Australia, Perth, Australia
Huiguang He, Chinese Academy of Sciences, Beijing, China
Paco Herson, Oregon Health and Science University, Portland, USA
David Hovda, University of California, Los Angeles, USA
Walter Huber, RWTH Aachen, Aachen, Germany
Ole Isacson, Harvard Medical School, Belmont, USA
Lyn B. Jakeman, Ohio State University Medical Center, Columbus, USA
Kunlin Jin, University of North Texas Health Science Center, Fort Worth, USA
Jukka Jolkkonen, University of Eastern Finland, Kuopio, Finland
Theresa A. Jones, University of Texas, Austin, USA
Monika Jungblut, Interdisciplinary Institute for Music- and Speech-Therapy, Duisburg, Germany
Jon H. Kaas, Vanderbilt University, Nashville, USA
MinYoung Kim, CHA University, Gyeonggi-do, Republic of Korea
Soo Young Kim, University of California Berkeley, Berkeley, USA
Yun-Hee Kim, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Teresa J. Kimberley, University of Minnesota, Minneapolis, USA
Anthony E. Kline, University of Pittsburgh, Pittsburgh, USA
Bryan E. Kolb, University of Lethbridge, Lethbridge, Canada
Boris Kotchoubey, University of Tuebingen, Tuebingen, Germany
Elisabetta Ládavas, University of Bologna, Bologna, Italy
Emma Lane, Cardiff University, Cardiff, Wales
Michelle LaPlaca, Georgia Tech, Atlanta, USA
Jongmin Lee, Konkuk University, Seoul, Korea
Shelly Levy-Tzedek, Hebrew University in Jerusalem, Jerusalem, Israel
Susan Mackinnon, Washington University , St. Louis, USA
Lamberto Maffei, Istituti di Neurofisiologia del C.N.R., Pisa, Italy
Hari Manev, University of Illinois at Chicago, Chicago, USA
Paolo Manganotti, University of Verona, Verona, Italy
Niklas Marklund, Uppsala University Hospital, Uppsala, Sweden
Per Mattsson, Karolinska Institutet, Stockholm, Sweden
Donald E. Mitchell, Dalhousie University, Halifax, Canada
Gabriela Moralí, Instituto Mexicano del Seguro Social , México City, México
Harald Müller, University Mainz, Mainz, Germany
Antonio Nardone, University of Eastern Piedmont and Fondazione Salvatore Maugeri (IRCCS), Novara, Italy
Xavier Navarro, University Barcelona, Barcelona, Spain
Michael A. Nitsche, University Goettingen, Goettingen, Germany
Antal Nógrádi, University of Szeged, Szeged, Hungary
Randolph Nudo, University Kansas, Kansas City, USA
Rosario Osta Pinzolas, Zaragoza University , Zaragoza, Spain
Martin Oudega, University of Pittsburgh School of Medicine, Pittsburgh, USA
Nam-Jong Paik, Seoul National University , Seoul, South Korea
Alvaro Pascual-Leone, Beth. Israel Hosp., Boston, USA
Walter Paulus, University Göttingen , Göttingen, Germany
Giovanni Pellegrino, Campus Bio-Medico University, Rome, Italy
Iris-Katharina Penner, University of Basel , Basel, Switzerland
Thomas Platz, Ernst-Moritz-Arndt University , Greifswald, Germany
Uri Polat, Tel Aviv University, Ramat Aviv, Israel
Alberto Priori, University of Milan, Fondazione IRCCS Ca', Granda Milan, Italy
Svetlana Pudnik, Case Western University, Cleveland, USA
Zhang Qinli, Shanxi Medical University, Taiyuan Shanxi, China
Geoffrey Raisman, UCL Institute of Neurology, London, United Kingdom
Julio J. Ramirez, Davidson College, Davidson, USA
Klaus Reymann, German Center for Neurodegenerative diseases (DZNE), Magdeburg, Germany
Ian H. Robertson, University of Dublin, Dublin, Ireland
Roberta Ronchi, IRCCS Istituto Auxologico Italiano, Milano, Italy
David Russell, Oslo University Hospital , Oslo, Norway
Mircea Ariel Schoenfeld, University Magdeburg, Magdeburg, Germany
Kiarash Shahlaie, University of California Davis, Sacramento, USA
Xue-feng F. Shi, Tianjin Eye Hospital and Institute, Tianjin Medical University, Tianjin, China
Jeffrey S. Smith, Saginaw Valley State University, Saginaw, USA
Kwok-Fai So, University of Hong Kong, Hong Kong, China
Cathy Stinear, The University of Auckland , Auckland, New Zealand
Jerzy P. Szaflarski, University of Alabama at Birmingham, Birmingham, USA
Elzbieta Szelag, Nencki Institute of Experimental Biology, Warsaw, Poland
Yong Tang, Chongqing Medical University, Chongqing, China
Peter A. Tass, Research Center Juelich , Juelich, Germany
Edward Taub, University Alabama at Birmingham, Birmingham, USA
Franca Tecchio, LET’S-ISTC-CNR, Rome, Italy
Solon Thanos, University of Münster, Münster, Germany
Eugene Tunik, University of New Jersey, Newark, USA
Gitendra Uswatte, University of Alabama at Birmingham, Birmingham, USA
Joost Verhaagen, Netherlands Institute for Brain Research, Amsterdam, Netherlands
Oliver Von Bohlen, University of Greifswald , Greifswald, Germany
Stephen Waxman, Yale University School of Medicine, New Haven, USA
Anja Wellejus, Nensius Research A/S, Copenhagen, Denmark
Sherry L. Willis, L. University of Texas, Austin, USA
Steven L. Wolf, L. Emory University , Atlanta, USA
Lan Zhang, Xuanwu Hospital of  Capital Medical University, Beijing, China
Sungchil Yang, University of California, San Francisco, USA
Xiaojun Zhang, Beijing Tongren Hospital, Capital Medical University, Beijing, China
Binhai Zheng, University of California San Diego, La Jolla, USA
Jacqueline Zöllig, University of Zurich, Zurich, Switzerland 

Reviewers

Yaomin Chen, University of Texas Southwestern Medical Center, Dallas, USA
Ying Dai, Deaconess Medical Center, Boston, USA 
Dalton Dietrich, University of Miami , Miami, USA
Edward D. Hall, University Kentucky, Lexington, USA
Patricia Hurn, Oregon Health & Sci. University, Portland, USA
Liaoliao Li, University of Virginia, Charlottesville, VA, USA
Nanxin "Nick" Li, Yale University, New Haven, USA
Jeffrey D. Rothstein, Johns-Hopkins University, Baltimore, USA
Timothy J. Schallert, University of Texas, Austin, USA
Wei Shen, Pfizer Neuroscience Research Unit, Cambridge, USA
Evan Y. Snyder, The Burnham Institute, La Jolla, USA
Jing Wang, Mount Sinai School of Medicine, New York, USA
Takehiko Yanagihara, Osaka Neurological Research Institute , Osaka, Japan

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Publication Fee
When an article is accepted for publication, authors are required to pay a publication fee of 550 USD / 400 €.

Open Access Option
In addition to the publication fee, authors have the option to make their article freely available on the Publisher's journal platform. For a charge of 1250 USD / 900 € your article (including pre-publication) will be freely accessible immediately upon publication. A form to request Open Access will be supplied with the acceptance letter. 

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Authors are requested to submit their manuscript electronically to www.mstracker.com.

Note that the manuscript should be uploaded as one file with tables and figures included. This file can be a Word document, a PDF, or an embedded or zip file (.rar) if separate high resolution figures or a supplemental file such as a video are also to be included with the submission (the file size maximum for a video is 25MB). If the video is too large to submit, please contact rnn@med.ovgu.de to arrange a file transfer. For further information about submitting supplementary data click here.

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All correspondence concerning editorial matters as well as information regarding submissions should be sent to:

Editor-in-Chief:
Bernhard A. Sabel, PhD
Institute of Medical Psychology
Otto-v.-Guericke University of Magdeburg
Leipzigerstr. 44
39120 Magdeburg
Germany
Tel. +49 391 672 1800
Fax +49 391 672 1803
Email: rnn@med.ovgu.de

Editorial Assistant:
Steffi Matzke

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Poggel, D.A., Kasten E. and Sabel, B.A. (2004). Attentional cueing improves vision restoration therapy in patients with visual field loss. Neurol, 63(11), 2069-2076.

Books:
Finger, S. & Stein, D.G. (1982). Brain damage and recovery. New York: Academic Press.

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User-Friendly Electronic “EyeCane” Enhances Navigational Abilities for the Blind

21 Oct 2014 - White Canes provide low-tech assistance to the visually impaired, but some blind people object to their use because they are cumbersome, fail to detect elevated obstacles, or require long training periods to master. Electronic travel aids (ETAs) have the potential to improve navigation for the blind, but early versions had disadvantages that limited widespread adoption. A new ETA, the “EyeCane,” developed by a team of researchers at The Hebrew University of Jerusalem, expands the world of its users, allowing them to better estimate distance, navigate their environment, and avoid obstacles, according to a new study published in Restorative Neurology and Neuroscience. ...

EyeMusic Sensory Substitution Device Enables the Blind to “See” Colors and Shapes

05 Feb 2014 - Using auditory or tactile stimulation, Sensory Substitution Devices (SSDs) provide representations of visual information and can help the blind “see” colors and shapes. SSDs scan images and transform the information into audio or touch signals that users are trained to understand, enabling them to recognize the image without seeing it....

2014 Neuroscience Neurology Brochure

31 Jan 2014 - Download the 2014 Neuroscience Neurology Brochure here. ...

Real-Time Video Feedback Could Improve Effect of Core Stabilization Exercise in Stroke Patients

31 Jan 2014 - About 80% of stroke survivors experience hemiparesis, which causes weakness or the inability to move one side of the body. Core stabilization exercise to improve postural stability and independent walking in chronic hemiparetic stroke patients could be enhanced by real-time video feedback, report researchers in Restorative Neurology and Neuroscience....

Residual Activity “Hot Spots” in the Brain Key for Vision Recovery in Stroke Patients

03 Jan 2014 - Scientists know that vision restoration training (VRT) can help patients who have lost part of their vision due to glaucoma, optic nerve damage, or stroke regain some of their lost visual functions, but they do not understand what factors determine how much visual recovery is achieved. ...

Corticosteroid Added to Standard Treatment Improves Eyesight in Patients with Sudden Vision Loss

20 Nov 2013 - Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the leading causes of sudden and irreversible loss of vision in older adults. In a prospective randomized trial of 60 patients with NAION, investigators have shown that the addition of the corticosteroid fluocortolone (FC) to standard therapy significantly improves both short- and long-term visual acuity, especially when given soon after the onset of symptoms. Their results are published in Restorative Neurology and Neuroscience....

Transcranial Direct Current Stimulation Improves Sleep in Patients with Post-Polio Syndrome

27 Aug 2013 - Of the 15 million people around the world who have survived poliomyelitis, up to 80% report progressive deteriorating strength and endurance many years after infection, a condition known as post-polio syndrome (PPS). Researchers in Italy from the National Hospital for Poliomyelitis, the Policlinico G.B. De Rossi in Verona, and the University of Milan have found that transcranial direct current stimulation (tDCS) for 15 days improved sleep and fatigue symptoms in patients with PPS, suggesting this non-invasive tool may be a new therapeutic option for this condition. Their results are published in Restorative Neurology and Neuroscience....

New Study Supports Intracerebral Injections of Bone Marrow-Derived Stem Cells to Prevent or Reduce Post-Stroke Cognitive Deficits

26 Aug 2013 - Cognitive deficits following ischemic stroke are common and debilitating, even in the relatively few patients who are treated expeditiously so that clots are removed or dissolved rapidly and cerebral blood flow restored. A new study in Restorative Neurology and Neuroscience demonstrates that intracerebral injection of bone-marrow-derived mesenchymal stem cells (BSCs) reduces cognitive deficits produced by temporary occlusion of cerebral blood vessels in a rat model of stroke, suggesting that BSCs may offer a new approach for reducing post-stroke cognitive dysfunction. ...

Novel Chinese Herbal Medicine JSK Improves Spinal Cord Injury Outcomes in Rats

20 Aug 2013 - A new study published in Restorative Neurology and Neuroscience demonstrates that Chinese herbal medicine Ji-Sui-Kang (JSK), given systemically for three weeks after injury in rats, improved locomotor function, reduced tissue damage, and preserved the structure of neural cells compared to control rats. The report also includes data showing that JSK may first act to reduce inflammation and cell apoptosis and death, and boost local oxygen supply while, later on, it appears to restore function and promote tissue regeneration. ...

Necrostatin-1 Counteracts Aluminum’s Neurotoxic Effects

05 Aug 2013 - Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer’s disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum’s neurotoxic effects....

Higher Education May Be Protective Against MS-Associated Cognitive Deficits

03 Jul 2013 - Multiple sclerosis (MS) can lead to severe cognitive impairment as the disease progresses. Researchers in Italy have found that patients with high educational levels show less impairment on a neuropsychological evaluation compared with those with low educational levels. Their results are published in Restorative Neurology and Neuroscience....

Short-Term Benefits Seen With Repetitive Transcranial Magnetic Stimulation for Focal Hand Dystonia

10 Apr 2013 - Repetitive transcranial magnetic stimulation (rTMS) is being increasingly explored as a therapeutic tool for movement disorders associated with deficient inhibition throughout the central nervous system. This includes treatment of focal hand dystonia (FHD), characterized by involuntary movement of the fingers either curling into the palm or extending outward. A new study published in Restorative Neurology and Neuroscience reports short-term changes in behavioral, physiologic, and clinical measures that support further research into the therapeutic potential of rTMS....

Shift of Language Function to Right Hemisphere Impedes Post-Stroke Aphasia Recovery

04 Apr 2013 - In a study designed to differentiate why some stroke patients recover from aphasia and others do not, investigators have found that a compensatory reorganization of language function to right hemispheric brain regions bodes poorly for language recovery. Patients who recovered from aphasia showed a return to normal left-hemispheric language activation patterns. These results, which may open up new rehabilitation strategies, are available in the current issue of Restorative Neurology and Neuroscience....

Shedding Light on Early Parkinson’s Disease Pathology

02 Apr 2013 - In a mouse model of early Parkinson’s disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the substantia nigra (SN), without the loss of nigral dopaminergic neurons. These findings, which may cast light on the molecular processes involved in the initial stages of PD, are available in the current issue of Restorative Neurology and Neuroscience....

Novel Herbal Compound Offers Potential to Prevent and Treat Alzheimer’s Disease

19 Feb 2013 - Administration of the active compound tetrahydroxystilbene glucoside (TSG) derived from the Chinese herbal medicine Polygonum multiflorum Thunb, reversed both overexpression of α-synuclein, a small protein found in the brain, and its accumulation using a mouse model of Alzheimer’s disease. These results, which may shed light on the neuropathology of AD and open up new avenues of treatment, are available in the current issue of Restorative Neurology and Neuroscience....

2013 Neuroscience Neurology Brochure

27 Nov 2012 - Download the 2013 Neuroscience Neurology Brochure here. ...

Abnormal Involuntary Eye Movements in the “Lazy Eye” Disease Amblyopia Linked to Changes in Subcortical Regions of the Brain

17 Oct 2012 - The neural mechanism underlying amblyopia, also called “lazy eye” is still not completely clear. A new study now reports abnormal eye movements of the lazy eye, which suggests that disturbed functioning of eye movement coordination between both eyes and not primarily the dysfunction of the visual cortex may be a cause of amblyopia (Xue-feng Shi et al.)....

Neural Interface for Hand Prosthesis Can Restore Function in Brain Areas Responsible for Motor Control

21 Aug 2012 - Amputation disrupts not only the peripheral nervous system but also central structures of the brain. While the brain is able to adapt and compensate for injury in certain conditions, in amputees the traumatic event prevents adaptive cortical changes. A group of scientists reports adaptive plastic changes in an amputee’s brain following implantation of multielectrode arrays inside peripheral nerves. Their results are available in the current issue of Restorative Neurology and Neuroscience. ...

Scientists Report Promising New Direction for Cognitive Rehabilitation in the Elderly

21 Aug 2012 - Research has found that declines in temporal information processing (TIP), the rate at which auditory information is processed, underlies the progressive loss of function across multiple cognitive systems in the elderly, including new learning, memory, perception, attention, thinking, motor control, problem solving, and concept formation. In a new study, scientists have found that elderly subjects who underwent temporal training improved not only the rate at which they processed auditory information, but also in other cognitive areas. The study is published in the current issue of Restorative Neurology and Neuroscience. ...

Therapy Combining Exercise and Neuroprotective Agent Shows Promise for Stroke Victims

16 Aug 2012 - In a study published in the current issue of Restorative Neurology and Neuroscience scientists report that a therapy combining exercise with the neurovascular protective agent S-nitrosoglutathione (GSNO) improved recovery from stroke in a rat model. GSNO is a compound found naturally in the body and it has no known side effects or toxicity. ...

Music to My Eyes: Device Converting Images into Music Helps Individuals without Vision Reach for Objects in Space

09 Jul 2012 - Sensory substitution devices (SSDs) use sound or touch to help the visually impaired perceive the visual scene surrounding them. The ideal SSD would assist not only in sensing the environment but also in performing daily activities based on this input. For example, accurately reaching for a coffee cup, or shaking a friend’s hand. In a new study, scientists trained blindfolded sighted participants to perform fast and accurate movements using a new SSD, called EyeMusic. Their results are published in the July issue of Restorative Neurology and Neuroscience....

Electrical Brain Stimulation Can Alleviate Swallowing Disorders after Stroke

02 Jul 2012 - After stroke, patients often suffer from dysphagia, a swallowing disorder that results in greater healthcare costs and higher rates of complications such as dehydration, malnutrition, and pneumonia. In a new study published in the July issue of Restorative Neurology and Neuroscience, researchers have found that transcranial direct current stimulation (tDCS), which applies weak electrical currents to the affected area of the brain, can enhance the outcome of swallowing therapy for post-stroke dysphagia. ...

Device Implanted in Brain Has Therapeutic Potential for Huntington’s Disease

19 Jun 2012 - Studies suggest that neurotrophic factors, which play a role in the development and survival of neurons, have significant therapeutic and restorative potential for neurologic diseases such as Huntington’s disease. However, clinical applications are limited because these proteins cannot easily cross the blood brain barrier, have a short half-life, and cause serious side effects. Now, a group of scientists has successfully treated neurological symptoms in laboratory rats by implanting a device to deliver a genetically engineered neurotrophic factor directly to the brain. They report on their results in the latest issue of Restorative Neurology and Neuroscience. ...

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