Journal of Parkinson's Disease

Journal of Parkinson’s Disease

ISSN print
ISSN online
4; 4 issues
Last issue (4:1) published on 14 February 2014
Next issue
4:2 scheduled for May 2014
Back volumes
Institutional subscription for 2014 €545 / US$720 Excluding VAT
Subscription Rates Free Sample Copy
Share this journal

Book Launch: The Case of the Frozen Addicts: How the Solution of a Medical Mystery Revolutionized the Understanding of Parkinson's Disease (2014)

In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were confronted with mysteriously “frozen” patients. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution lay in the most daring area of research: fetal-tissue transplants. Written by J. William Langston and Jon Palfreman, this is the spell-binding story behind a headline that garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This new updated edition of the classic neurological mystery tale can now be ordered in print, epub or pdf format.

New Sister Journal: Journal of Neuromuscular Diseases

JPD welcomes a new sister journal: Journal of Neuromuscular Diseases (JND), edited by Carsten G. Bönnemann and Hanns Lochmüller. This journal is now accepting papers. The first 2 volumes will be freely available.

The Journal of Parkinson’s Disease is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that will expedite our fundamental understanding and improve treatment of Parkinson’s disease. The journal is international and multidisciplinary and aims to promote progress in the epidemiology, etiology, genetics, molecular correlates, pathogenesis, pharmacology, psychology, diagnosis and treatment of Parkinson’s disease. It will publish research reports, reviews, short communications, and letters-to-the-editor and offers very rapid publication and an affordable open access option.








Patrik Brundin, MD, PhD
Van Andel Research Institute
Grand Rapids, MI, USA
Wallenberg Neuroscience Center
Lund University, Lund, Sweden

J. William Langston, MD
The Parkinson's Institute and Clinical Center
Sunnyvale, CA, USA

Associate Editor for Reviews

M. Angela Cenci
Lund University, Lund, Sweden

Associate Editors

Roger Barker
University of Cambridge, Cambridge, United Kingdom

Bastiaan Bloem
University Medical Centre St Radboud, Nijmegen, The Netherlands

Mark R. Cookson
NIH, Bethesda, USA  

Dennis Dickson
Mayo Clinic, Scottsdale, USA

Robert H. Edwards
University of California San Francisco, San Francisco, USA  

Howard Federoff
Georgetown University, Washington, USA

Thomas Gasser
University of Tuebingen, Tuebingen, Germany

Glenda Halliday
The University of New South Wales, Sydney, Australia

Jan Petter Larsen
University of Stavanger, Stavanger, Norway

Peter A. LeWitt
Wayne State University, Detroit, USA
Henry Ford Hospital, Detroit, USA

Tamas Revesz
University College London, London, United Kingdom

Eng King Tan
Duke NUS Graduate Medical School, Singapore, Singapore

Jens Volkmann
Universitätsklinikum Wurzburg, Wurzburg, Germany

Nick Wood
University College London, London, United Kingdom

Social Media Editor

Jon Palfreman
University of Oregon, Eugene, USA

Managing Editor

Bethany Kumar
Case Western Reserve University, Cleveland, USA

Editorial Board

Dag Aarsland
University of Stavanger, Stavanger, Norway

Asa Abeliovich
Columbia University College of Physicians & Surgeons, New York, USA

Patrick Aebischer 
École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland   

Yves Agid
Institut du Cerveau et de la Moelle épinière, Paris, France

Alberto Albanese
National Neurological Hospital Carlo Besta, Milan, Italy

Ernest Arenas
Karolinska Institute, Stockholm, Sweden

Alberto Ascherio
Harvard School of Public Health, Boston, USA

M. Flint Beal
Weill Medical College of Cornell University, New York, USA

Alim Benabid
University of Grenoble, Grenoble, France

Hagai Bergman
The Hebrew University, Jerusalem, Israel

Anders Björklund
Lund University, Lund, Sweden

Vincenzo Bonifati
Erasmus MC, Rotterdam, The Netherlands

Heiko Braak
University of Ulm, Ulm, Germany

Alexis Brice   
Pierre and Marie Curie University, Paris, France

David J. Brooks
Hammersmith Hospital, London, United Kingdom

Robert Burke
Columbia University Medical Center, New York, USA

Paolo Calabresi
University of Perugia, Perugia, Italy

Piu Chan
Beijing Institute of Geriatrics, Beijing, China

K. Ray Chaudhuri
Kings College Hospital, London, United Kingdom

Marie Francoise Chesselet
University of California Los Angeles, Los Angeles, USA

Cynthia Comella
Rush University Medical Center, Chicago, USA

Ted M. Dawson
Johns Hopkins University School of Medicine, Baltimore, USA  

Valina L. Dawson
Johns Hopkins University School of Medicine, Baltimore, USA

David Eidelberg
The Feinstein Institute for Medical Research, New York, USA

Omar M. El-Agnaf
United Arab Emirates University, Al-Ain, United Arab Emirates

Stanley Fahn
Columbia University College of Physicians & Surgeons, New York, USA

Matt Farrer
University of British Columbia, Vancouver, Canada

Joaquim Ferreira   
Hospital de Santa Maria, Lisbon, Portugal

Nir Giladi
Tel Aviv University, Tel Aviv, Israel

Ann M. Graybiel
MIT, Cambridge, USA

J. Timothy Greenamyre
University of Pittsburgh, Pittsburgh, USA

James G. Greene
Emory University, Atlanta, USA

Katrina Gwinn
NIH, Bethesda, USA

Mark Hallett
NIH, Bethesda, USA

John Hardy
University College London, London, United Kingdom

Nobutaka Hattori
Juntendo University School of Medicine, Tokyo, Japan

Etienne C. Hirsch
Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Paris, France

Joseph Jankovic
Baylor College of Medicine, Houston, USA  

Christine Klein
University of Lübeck, Lübeck, Germany

Amos D. Korczyn
Tel Aviv University, Ramat Aviv, Israel

Jeffrey H. Kordower
Rush University, Chicago, USA

Seung-Jae Lee  
Konkuk University, Seoul, South Korea

Virginia Lee
University of Pennsylvania School of Medicine, Philadelphia, USA

Olle Lindvall
Lund University, Lund, Sweden

Andres Lozano
University of Toronto, Toronto, Canada

Laura Marsh
Baylor College of Medicine, Houston, USA

Mark P. Mattson
National Institute on Aging, Baltimore, USA

Eldad Melamed
Tel Aviv University, Tel Aviv, Israel

Alice Nieuwboer
Catholic University Leuven, Leuven, Belgium

Robert Nussbaum
University of California San Francisco, San Francisco, USA

Ronald F. Pfeiffer
University of Tennessee Health Science Center, Memphis, USA

Pierre Pollak
University of Grenoble, Grenoble, France

Serge Przedborski
Columbia University Medical Center, New York, USA

Niall Quinn
University College London, London, United Kingdom

Heinz Reichmann
University of Dresden, Dresden, Germany

Peter Riederer
University of Wuerzburg, Wuerzburg, Germany

Trevor Robbins
University of Cambridge, Cambridge, United Kingdom

Anthony Schapira
University College London, London, United Kingdom

Todd Sherer
Michael J. Fox Foundation, New York, USA

Ira Shoulson
Georgetown University, Washington, USA

Andrew Singleton
NIH, Bethesda, USA  

David G. Standaert
University of Alabama at Birmingham, Birmingham, USA

Dennis Steindler
University of Florida, Gainesville, USA

Gerald Stern
University College Hospitals, London, United Kingdom

Fabrizio Stocchi
IRCCS San Raffaele, Rome, Italy

A. Jon Stoessl
University of British Columbia, Vancouver, Canada

Michele Tagilati
Cedars-Sinai Medical Center, Los Angeles, USA

Jun Takahashi
Kyoto University, Kyoto, Japan

Caroline M. Tanner
The Parkinson's Institute and Clinical Center, Sunnyvale, USA

Eduardo Tolosa
University of Barcelona, Barcelona, Spain

John Q. Trojanowski
Hospital of the University of Pennsylvania, Philadelphia, USA

Daniel Weintraub
University of Pennsylvania, Philadelphia, USA

Founding Editors
From the Journal of Alzheimer’s Disease

George Perry
University of Texas at San Antonio, San Antonio, USA

Mark A. Smith†
Case Western Reserve University, Cleveland, USA

See instructions to authors.

Biomedical Reference Collection
Chemical Abstracts Service (CAS)
Journal Citation Reports/Science Edition
Science Citation Index-Expanded (SciSearch®)

2014 Neuroscience Neurology Brochure

31 Jan 2014 - Download the 2014 Neuroscience Neurology Brochure here. ...

Higher Vitamin D Levels Associated with Better Cognition and Mood in Parkinson’s Disease Patients

17 Jan 2014 - A new study exploring vitamin D levels in patients with Parkinson’s disease (PD) opens up the possibility of a new avenue of early intervention that may delay or prevent the onset of cognitive impairment and depression. The findings are published in the Journal of Parkinson’s Disease....

New Research Suggests Changes in Parietal Brain Gray Matter Volume Associated with Memory Deficits in Early PD

17 Jan 2014 - Research by a team of investigators in Finland suggests that the free recall memory deficits common even in early stages Parkinson’s disease (PD) are related to structural changes in the brain, specifically parietal cortical gray matter volume. Their findings are published in the current issue of the Journal of Parkinson’s Disease....

New Study Links Depression in Newly Diagnosed Parkinson’s Disease Patients to Reduced Striatal Dopamine Synthesis

10 Oct 2013 - According to the Parkinson’s Disease Foundation, up to 60% of individuals with Parkinson’s disease (PD) exhibit mild to moderate depression, which is often underdiagnosed. It is unclear whether depression results from having a debilitating disease or reflects a parallel abnormal change in the brain caused by PD pathophysiology. ...

PD-Like Sleep and Motor Problems Observed in α-Synuclein Mutant Mice

11 Jun 2013 - The presence of Lewy bodies in nerve cells, formed by intracellular deposits of the protein α-synuclein, is a characteristic pathologic feature of Parkinson’s Disease (PD). In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α-synuclein. By studying a strain of mice bred to overexpress α-synucl...

Shedding Light on Early Parkinson’s Disease Pathology

02 Apr 2013 - In a mouse model of early Parkinson’s disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the substantia nigra (SN), without the loss of nigral dopaminergic neurons. These findings, which may cast light on the molecular processes involved in the initial stages of PD, are available in the curr...

Blood-Based Biomarkers May Lead to Earlier Diagnosis of Parkinson’s Disease

21 Jan 2013 - Parkinson's disease (PD) is a progressive neurological condition. At present, it is usually diagnosed only when motor features are present. Hence, there is a need to develop objective and measurable biomarkers to improve PD diagnostics during its earlier stage, prior to its motor onset. In this pilot study, researchers identified and tested the first blood-based circulating microRNA (miRNA) biomar...

2013 Neuroscience Neurology Brochure

27 Nov 2012 - Download the 2013 Neuroscience Neurology Brochure here. ...

Years before Diagnosis, Quality of Life Declines for Parkinson’s Disease Patients

02 Jul 2012 - Growing evidence suggests that Parkinson’s disease (PD) often starts with non-motor symptoms that precede diagnosis by several years. In the first study to examine patterns in the quality of life of Parkinson’ disease patients prior to diagnosis, researchers have documented declines in physical and mental health, pain, and emotional health beginning several years before the onset of the disea...

Sleep Improves Functioning in Parkinson’s Patients, but Reasons Remain Elusive

20 Jun 2012 - Some Parkinson’s patients report that their motor function is better upon awakening in the morning, which is contrary to what would be expected after a night without medication. This phenomenon, known as sleep benefit, has been studied but no consistent variables have been found and in the last decade there has been little new research. A new study, published in the June issue of the Journal of...

19th Century Therapy for Parkinson’s Disease May Help Patients Today

23 Apr 2012 - In the 19th century, the celebrated neurologist, Jean-Martin Charcot, developed a “vibration chair” to relieve symptoms of Parkinson’s disease. He reported improvements in his patients, but he died shortly thereafter and a more complete evaluation of the therapy was never conducted. Now a group of scientists at Rush University Medical Center have replicated his work, and they report that wh...

New Findings and Imaging Techniques May Aid Diagnosis of Concomitant Alzheimer’s in Patients with Parkinson’s Disease Dementia

17 Apr 2012 - Dementia is a frequent complication of Parkinson’s disease (PD), but it is clinically impossible to distinguish PD dementia (PDD), which develops from the progression of the Lewy body pathology that underlies PD, from PD with coexistent Alzheimer’s disease (PDAD). Both have similar characteristics. A team of scientists has found that PDAD patients have much denser accumulations of amyloid plaq...

Journal of Parkinson's Disease Brochure 2012

27 Feb 2012 - Download the Journal of Parkinson's Disease Brochure 2012 here. ...

Scientists Report First Step in Strategy for Cell Replacement Therapy in Parkinson’s Disease

25 Jan 2012 - Induced pluripotent stem cells (iPSC) are a promising avenue for cell replacement therapy in neurologic diseases. For example, mouse and human iPSCs have been used to generate dopaminergic (DA) neurons that improve symptoms in rat Parkinson’s disease models. Reporting in the current issue of the Journal of Parkinson’s Disease, a group of scientists from Japan evaluated the growth, differentiat...

New Research Reveals How α-Synuclein Interacts with Cell Membranes in Parkinson’s Disease

19 Jan 2012 - The accumulation of α-synuclein, a small, negatively charged protein, in neural cells, is one of the hallmarks of Parkinson’s disease. It has been suggested that oligomeric α-synuclein causes membranes to become permeable, or to form channels on the outer cell membrane. Now, a group of scientists from Sweden has found a way to reliably replicate α-synuclein aggregation on cell membranes to ...

New Study Supports View that Lewy Bodies Are Not the Primary Cause of Cell Death in Parkinson’s Disease

10 Jan 2012 - The pathology of Parkinson’s disease is characterized by a loss of dopamine-producing neurons in the pars compacta of the substantia nigra (SN), an area of the brain associated with motor control, along with the development of α-synuclein (αS) protein in the form of Lewy bodies (LB) in the neurons that survive. The spread of LB pathology is thought to progress along with the clinical course o...

Genetic Factors Can Predict the Progression of Parkinson’s Disease

16 Dec 2011 - Parkinson’s disease is marked by the abnormal accumulation of α-synuclein and the early loss of dopamine neurons in the substantia nigra region of the brain. A polymorphism in the promotor of α-synuclein gene known as NACP-Rep1 has been implicated as a risk factor for the disease. Now, researchers have found that different variants of NACP-Rep1 and its interaction with the microtubule-associa...

New Study First to Link Mitochondrial Dysfunction and alpha-Synuclein Multiplication in Human Fibroblasts

07 Oct 2011 - A new study in the Journal of Parkinson’s Disease shows for the first time the effects of α-Synuclein (α-syn) gene multiplication on mitochondrial function and susceptibility to oxidative stress in human tissue. Mitochondrial dysfunction has been frequently implicated in the neurodegenerative process that underlies Parkinson’s disease, but the basis for this has not been fully understood. ...

Ability to Ride a Bike Can Aid Differential Diagnosis of Parkinson’s Disease in Any Setting

07 Oct 2011 - In a new study published today in the Journal of Parkinson’s Disease, Japanese researchers report that the ability to ride a bike can differentiate between atypical parkinsonism and Parkinson’s disease, regardless of the environment or situations for bicycling. ...