Journal of Parkinson’s Disease
The Journal of Parkinson’s Disease is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that will expedite our fundamental understanding and improve treatment of Parkinson’s disease. The journal is international and multidisciplinary and aims to promote progress in the epidemiology, etiology, genetics, molecular correlates, pathogenesis, pharmacology, psychology, diagnosis and treatment of Parkinson’s disease. It will publish research reports, reviews, short communications, and letters-to-the-editor and offers very rapid publication and an affordable open access option.
Click here to see: Editor-in-Chief Patrik Brundin introduces the Journal of Parkinson’s Disease.
Patrik Brundin, MD, PhD
J. William Langston, MD
Associate Editor for Reviews
M. Angela Cenci
Mark R. Cookson
Robert H. Edwards
Jan Petter Larsen
Peter A. LeWitt
Social Media Editor
M. Flint Beal
David J. Brooks
K. Ray Chaudhuri
Marie Francoise Chesselet
Ted M. Dawson
Valina L. Dawson
Omar M. El-Agnaf
Ann M. Graybiel
J. Timothy Greenamyre
James G. Greene
Etienne C. Hirsch
Jeffrey H. Kordower
Mark P. Mattson
Ronald F. Pfeiffer
David G. Standaert
A. Jon Stoessl
Eng King Tan
Caroline M. Tanner
John Q. Trojanowski
Mark A. Smith†
Journal Citation Reports/Science Edition
Science Citation Index-Expanded (SciSearch®)
16 June 2013 - 20 June 2013
MDS European Summer School for Young Neurologists
26 July 2013 - 28 July 2013
XXI World Congress of Neurology
21 September 2013 - 26 September 2013
World Parkinson Congress
01 October 2013 - 04 October 2013
XX WFN World Congress on Parkinson’s Disease and Related Disorders
08 December 2013 - 11 December 2013
02 Apr 2013 - In a mouse model of early Parkinson’s disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the substantia nigra (SN), without the loss of nigral dopaminergic neurons. These findings, which may cast light on the molecular processes involved in the initial stages of PD, are available in the curr...
21 Jan 2013 - Parkinson's disease (PD) is a progressive neurological condition. At present, it is usually diagnosed only when motor features are present. Hence, there is a need to develop objective and measurable biomarkers to improve PD diagnostics during its earlier stage, prior to its motor onset. In this pilot study, researchers identified and tested the first blood-based circulating microRNA (miRNA) biomar...
27 Nov 2012 - Download the 2013 Neuroscience Neurology Brochure here. ...
02 Jul 2012 - Growing evidence suggests that Parkinson’s disease (PD) often starts with non-motor symptoms that precede diagnosis by several years. In the first study to examine patterns in the quality of life of Parkinson’ disease patients prior to diagnosis, researchers have documented declines in physical and mental health, pain, and emotional health beginning several years before the onset of the disea...
20 Jun 2012 - Some Parkinson’s patients report that their motor function is better upon awakening in the morning, which is contrary to what would be expected after a night without medication. This phenomenon, known as sleep benefit, has been studied but no consistent variables have been found and in the last decade there has been little new research. A new study, published in the June issue of the Journal of...
23 Apr 2012 - In the 19th century, the celebrated neurologist, Jean-Martin Charcot, developed a “vibration chair” to relieve symptoms of Parkinson’s disease. He reported improvements in his patients, but he died shortly thereafter and a more complete evaluation of the therapy was never conducted. Now a group of scientists at Rush University Medical Center have replicated his work, and they report that wh...
New Findings and Imaging Techniques May Aid Diagnosis of Concomitant Alzheimer’s in Patients with Parkinson’s Disease Dementia
17 Apr 2012 - Dementia is a frequent complication of Parkinson’s disease (PD), but it is clinically impossible to distinguish PD dementia (PDD), which develops from the progression of the Lewy body pathology that underlies PD, from PD with coexistent Alzheimer’s disease (PDAD). Both have similar characteristics. A team of scientists has found that PDAD patients have much denser accumulations of amyloid plaq...
27 Feb 2012 - Download the Journal of Parkinson's Disease Brochure 2012 here. ...
25 Jan 2012 - Induced pluripotent stem cells (iPSC) are a promising avenue for cell replacement therapy in neurologic diseases. For example, mouse and human iPSCs have been used to generate dopaminergic (DA) neurons that improve symptoms in rat Parkinson’s disease models. Reporting in the current issue of the Journal of Parkinson’s Disease, a group of scientists from Japan evaluated the growth, differentiat...
19 Jan 2012 - The accumulation of α-synuclein, a small, negatively charged protein, in neural cells, is one of the hallmarks of Parkinson’s disease. It has been suggested that oligomeric α-synuclein causes membranes to become permeable, or to form channels on the outer cell membrane. Now, a group of scientists from Sweden has found a way to reliably replicate α-synuclein aggregation on cell membranes to ...
New Study Supports View that Lewy Bodies Are Not the Primary Cause of Cell Death in Parkinson’s Disease
10 Jan 2012 - The pathology of Parkinson’s disease is characterized by a loss of dopamine-producing neurons in the pars compacta of the substantia nigra (SN), an area of the brain associated with motor control, along with the development of α-synuclein (αS) protein in the form of Lewy bodies (LB) in the neurons that survive. The spread of LB pathology is thought to progress along with the clinical course o...
16 Dec 2011 - Parkinson’s disease is marked by the abnormal accumulation of α-synuclein and the early loss of dopamine neurons in the substantia nigra region of the brain. A polymorphism in the promotor of α-synuclein gene known as NACP-Rep1 has been implicated as a risk factor for the disease. Now, researchers have found that different variants of NACP-Rep1 and its interaction with the microtubule-associa...
New Study First to Link Mitochondrial Dysfunction and alpha-Synuclein Multiplication in Human Fibroblasts
07 Oct 2011 - A new study in the Journal of Parkinson’s Disease shows for the first time the effects of α-Synuclein (α-syn) gene multiplication on mitochondrial function and susceptibility to oxidative stress in human tissue. Mitochondrial dysfunction has been frequently implicated in the neurodegenerative process that underlies Parkinson’s disease, but the basis for this has not been fully understood. ...
07 Oct 2011 - In a new study published today in the Journal of Parkinson’s Disease, Japanese researchers report that the ability to ride a bike can differentiate between atypical parkinsonism and Parkinson’s disease, regardless of the environment or situations for bicycling. ...