IOSPress

Scientists Reveal Early Diagnostic Clues for Alzheimer’s Disease Using Advanced Brain Imaging Technology

03 May 2012 -

Alzheimer's disease (AD) is a major neurodegenerative disorder that affects millions of people worldwide. New and accurate techniques for early diagnosis are critical. Pravat K. Mandal, PhD, and his colleagues have developed a completely non-invasive brain imaging technique to measure specific brain chemical changes. This provides a signature of the early stages of AD from the hippocampal regio...

Anders Lönneborg, PhD, Receives 2012 Alzheimer Award

02 May 2012 -

Anders Lönneborg, PhD, has been chosen as the recipient of the 2012 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on the detection of early Alzheimer’s disease.

“My co-authors and I are extremely pleased to have been chosen ...

WesternU Dean to publish Alzheimer’s research

18 Apr 2012 - Michel Baudry, PhD, dean of the Graduate College of Biomedical Sciences at Western University of Health Sciences, will publish his research on the critical role of oxidative stress in Alzheimer’s disease and a potential treatment....

Antioxidant May Disrupt Alzheimer's Disease Process

10 Apr 2012 - Alzheimer’s disease (AD) is now the sixth leading cause of death among Americans, affecting nearly 1 in 8 people over the age of 65. There is currently no treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals like copper and zinc may start years before the onset of AD symptoms. A new stu...

Pulse Pressure Elevation Could Presage Cerebrovascular Disease in Alzheimer’s Patients

10 Apr 2012 - Researchers at the University of California, San Diego and Veterans Affairs San Diego Healthcare System have shown that elevated pulse pressure may increase the risk of cerebrovascular disease (CVD) in older adults with Alzheimer’s disease (AD). Their study has been published in the early online edition of Journal of Alzheimer's Disease in advance of the June 5 print publication....

Amyloid beta in the brain of individuals with Alzheimer’s disease

02 Apr 2012 - The deposition of amyloid beta in the brain of individuals with Alzheimer’s disease is the focus of much research into both its cause and treatment. ...

MRI and neuropsychological tests best predict Alzheimer’s disease in old patients

02 Apr 2012 - Investigators from the University of Amsterdam, Netherlands, have shown that in most elderly patients invasive and expensive techniques, i.e. lumbar puncture and PET scan, are not useful to establish the diagnosis of Alzheimer’s disease. They arrived at this conclusion after analysis of data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a large collaborative research project of ...

Brain atrophy can predict further cognitive decline in Alzheimer’s disease

27 Mar 2012 - Researchers from the Alzheimer Center, VU University Medical Center in Amsterdam, the Netherlands, have found a way to predict clinical progression of Alzheimer’s disease in subjects in the predementia stage. Patients with mild memory problems, who had brain atrophy on MRI scan or a high level of tau protein in cerebrospinal fluid showed more rapid cognitive decline than subjects without this sh...

Role of Amyloid Beta as Sensors and Protectors in Alzheimer’s and Other Diseases Explored

27 Mar 2012 - Alzheimer’s disease is the sixth leading cause of death in the United States and the only cause of death among the top 10 in America without a way to prevent, cure or even slow its progression, according to the Alzheimer’s Association. Today, 5.4 million Americans are living with the disease, and another American develops it every 69 seconds....

Variability in blood-based amyloid-β assays: The need for consensus on pre-analytical processing

26 Mar 2012 - Associate Professor Kevin Barnham from the Mental Health Research Institute has recently finished a report that highlights both the need for standard blood collection and processing methods in Alzheimer’s disease research, and a way forward. ...

Ein neuer Test könnte die Diagnose und Entwicklung von Medikamenten für die Alzheimer-Krankheit erleichtern

26 Mar 2012 - Ein internationales Team von Forschern hat eine neue Methode zur Messung des im Gehirn abgelagerten Beta-Amyloid entwickelt. Dieser Protein-Komplex steht im Verdacht, größere Schädigungen von Nervenzellen sowie Dysfunktionen bei der Alzheimer-Krankheit zu verursachen. Die neue Methode könnte die Erkennung der Erkrankung sowie Entwicklung von Medikamenten gegen diesen Protein-Komplex erleichter...

A new test might facilitate diagnosis and drug development for Alzheimer’s disease

26 Mar 2012 - An international team of researchers have developed a new method for measurement of aggregated beta-amyloid – a protein complex believed to cause major nerve cell damage and dysfunction in Alzheimer’s disease. The new method might facilitate diagnosis and detection as well as development of drugs directed against aggregated beta-amyloid....

Cognitive problems common among non-demented elderly

26 Mar 2012 - Both subjective and objective cognitive impairment are highly common among non-demented elderly Swedes, with an overall prevalence of 39 percent and 25 percent respectively, according to a nation-wide twin-study by researchers at the Aging Research Center of Karolinska Institutet, Sweden. The study confirms higher education as a major protective factor and stresses the importance of environmental ...

New hope for treating Alzheimer's Disease: A Role for the FKBP52 protein

21 Mar 2012 - New research in humans published today reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer’s drugs and for detecting the disease before the onset of clinical symptoms....

Scientists pinpoint how vitamin D may help clear amyloid plaques found in Alzheimer's

06 Mar 2012 - A team of academic researchers has identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer's disease. ...

Walnuts may boost Memory and Improve Cognitive Function

01 Mar 2012 - Do you recall what you ate for breakfast today or dinner last night? According to new research, you may have a better chance remembering if you had included walnuts. Recent findings published in the Journal of Alzheimer’s Disease report walnut consumption in a Mediterranean diet is associated with better memory scores and cognitive function. The results suggest that antioxidants present in walnu...

Nottingham scientists uncover new clues for early diagnosis of Alzheimer’s

07 Feb 2012 - Scientists in Nottingham have found abnormal levels of seven different proteins in spinal fluid could act as markers for detecting Alzheimer’s disease. The study, which was part-funded by Alzheimer’s Research UK, the UK’s leading dementia research charity, could lead to the development of a new test to detect the disease in its early stages....

New Study Challenges Accepted Approaches to Research in Senile Dementia (Alzheimer’s Disease)

07 Nov 2011 - Amsterdam, NL, 7 November 2011 – Impacting millions of families and devouring billions of dollars globally, Alzheimer’s disease is the focus of exhaustive research to find a cure. Although intensely investigated over the last three decades using cutting-edge technologies, the “pathogenic cause” of Alzheimer’s disease has not been found. While many research “breakthroughs” have been...

Could hypertension drugs help people with Alzheimer’s?

19 Oct 2011 - Within the next 20 years it is expected the number of people with Alzheimer’s disease (AD) will double from its current figure of half a million to one million. A new study has looked at whether certain types of drugs used to treat high blood pressure, also called hypertension, might have beneficial effects in reducing the number of new cases of Alzheimer’s disease each year. ...

Advances in Brain Imaging Can Expedite Research and Diagnosis in Alzheimer’s Disease

11 Oct 2011 - Alzheimer’s disease (AD) is a common problem that is becoming progressively burdensome throughout the world. A new supplement to the Journal of Alzheimer’s Disease, Imaging the Alzheimer Brain, clearly shows that multiple imaging systems are now available to help understand, diagnose, and treat the disease. ...

Blood tests may hold clues to pace of alzheimer’s disease progression

04 Oct 2011 - A team of scientists, led by Johns Hopkins researchers, say they may have found a way to predict how quickly patients with Alzheimer’s disease (AD) will lose cognitive function by looking at ratios of two fatty compounds in their blood. The finding, they say, could provide useful information to families and caregivers, and might also suggest treatment targets for this heartbreaking and incurab...

Scientists uncover new clues to Alzheimer’s risk gene that affects one in six

07 Sep 2011 - UK scientists have uncovered how a known risk gene for Alzheimer’s might play a role in the development of the disease. The study – which was funded by Alzheimer’s Society and Alzheimer’s Research UK – provides an exciting new area of investigation for researchers developing treatments and ultimately a cure for the disease. It is being published in the current issue of the Journal of Alz...