JAD_13

Journal of Alzheimer’s Disease

impact factor 2014 3.612
ISSN print
1387-2877
ISSN online
1875-8908
Volume
43-48; 24 issues
Status
Last issue (43:2) online on 21 November 2014
Next issue
43:3 scheduled for December 2014
Back volumes
1-42
Website
www.j-alz.com
Subject
Biochemistry, Medicine & Health, Neurosciences
Institutional subscription for 2015 €2350 / US$3200 Excluding VAT
Subscription Rates Free Sample Copy
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JAD Introduces New Section: Ethics Review
The Journal of Alzheimer’s Disease has launched a new feature, “Ethics Review,” which will provide support and guidance to move ethical decision-making forward. The goal is to create a forum for dementia researchers, clinicians[removed comma] and policy makers to bring greater clarity and constructive discussion to define risks and benefits from the perspectives of diverse disciplines. The first contribution, "Ethics Review as a Catalyst for Progress" by Allyson C. Rosen, John Wesson Ashford and George Perry is freely available online

New Sister Journal: Journal of Neuromuscular Diseases
JAD welcomes a new sister journal: Journal of Neuromuscular Diseases (JND), edited by Carsten G. Bönnemann and Hanns Lochmüller. The second issue of JND is now freely available online. This journal is accepting papers

The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer’s disease.

In Remembrance of Editor-in-Chief Mark A. Smith

Click here to read JAD's article on the top 100 researchers in Alzheimer's Disease, free of charge.

Editor-in-Chief
George Perry, PhD
College of Sciences
University of Texas at San Antonio
One UTSA Circle
San Antonio, Texas 78249, USA
Tel: +1.210.458.4450
Fax:+1.210.458.4445

Managing Editor
Beth Kumar
Department of Pathology
Case Western Reserve University
2103 Cornell Road
Cleveland, Ohio 44106, USA
Email: editorial@j-alz.com
Tel:+1.216.368.3671
Fax:+1.216.368.8964

Deputy Editor
Jesus Avila

Deputy Editor
Xiongwei Zhu

Deputy Editor
Massimo Tabaton

Scientometrics Editor
Aaron A. Sorensen

Former Editor-in-Chief, 2001-2010
Mark A. Smith, PhD

Senior Editors
Alejandra Alonso
Gary Arendash
J. Wesson Ashford
Claudio Babiloni
Barbara Borroni
Jack C. de la Torre
Daniela Galimberti
Amos Korczyn
Debomoy Lahiri
Piotr Lewczuk
Patrizia Mecocci
Miguel Medina
Thomas Shea
Henrik Zetterberg

Associate Editors
Please find the full list of the Associate Editors at http://j-alz.com/board.

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Mind before matter: do negative thoughts increase risk of Alzheimer’s disease?

19 Nov 2014 - Researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London have proposed that repetitive negative thinking (RNT), a common symptom of many psychological disorders, may increase the risk of developing Alzheimer’s disease....

New Research on Walnuts and the Fight Against Alzheimer’s Disease

22 Oct 2014 - A new animal study published in the Journal of Alzheimer’s Disease indicates that a diet including walnuts may have a beneficial effect in reducing the risk, delaying the onset, slowing the progression of, or preventing Alzheimer’s disease. ...

People at high risk of Alzheimer’s may have early visuomotor difficulties

08 Oct 2014 - Before there are any telltale behavioural signs of dementia, a simple test that combines thinking and movement could point to those with a heightened risk of developing Alzheimer’s disease and who are already having visuomotor difficulties, according to new research out of York University....

UB researchers corroborate the neuroprotective effects of Sirtuin 1 activation on mice with Alzheimer’s disease

07 Oct 2014 - A study coordinated by the University of Barcelona (UB) has described a mechanism that plays a key role in the evolution of Alzheimer’s disease. According to the paper published in the Journal of Alzheimer’s Disease, the activation of the protein Sirtuin 1 in a murine model with familial Alzheimer’s disease has neuroprotective effects. The study, based on the PhD thesis developed by the researcher David Porquet (UB), first describes Sirtuin 1 pathway in this murine model. Mercè Pallàs, from the Department of Pharmacology and Therapeutic Chemistry at the Faculty of Pharmacy of UB, coordinates the study. The Bellvitge Biomedical Research Institute (IDIBELL) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) also collaborate in the study. ...

Marijuana compound may offer treatment for Alzheimer’s disease, University of South Florida preclinical study indicates

30 Sep 2014 - Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease, a recent study from neuroscientists at the University of South Florida shows....

Conversion of mild cognitive impairment to dementia among subjects with diabetes

17 Sep 2014 - Findings by researchers at the School of Public Health of Tianjin Medical University suggest that in a survival analysis of the cohorts, Type 2 diabetes mellitus with mild cognitive impairment (T2DM-MCI) accelerated the median progression to dementia by 2.74 years. ...

Study Finds Air Pollution Harmful to Young Brains

17 Sep 2014 - Pollution in many cities threatens the brain development in children. Findings by University of Montana Professor Dr. Lilian Calderón-Garcidueñas, MA, MD, Ph.D., and her team of researchers reveal that children living in megacities are at increased risk for brain inflammation and neurodegenerative changes, including Alzheimer’s or Parkinson’s disease. ...

Diabetes Mellitus and Mild Cognitive Impairment: Higher Risk in Middle Age?

03 Sep 2014 - Essen, Germany, September 2, 2014 – In a large population-based study of randomly selected participants in Germany, researchers found that mild cognitive impairment (MCI) occurred twice more often in individuals diagnosed with diabetes mellitus type 2. Interestingly, this strong association was only observed in middle-aged participants (50-65 years), whereas in older participants (66-80 years) the association vanished. This study is published in the Journal of Alzheimer’s Disease....

Marijuana compound may offer treatment for Alzheimer’s disease

01 Sep 2014 - Tampa, FL -- Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease, a recent study from neuroscientists at the University of South Florida shows....

Computerized Cognition Test Provides Better Assessment than Observation

28 Aug 2014 - Research published in the Journal of Alzheimer’s Disease this week suggests healthy older adults are less capable of observing their own cognitive decline over an 18 month period than Cogstate’s computerized brief battery (CBB). The study, conducted by neuropsychologists, also indicated that close family members were unable to perceive decline in the cognitive behavior of their partner and trial participant in social settings. ...

Human Brain Deficits of PKCe: Targeted for Alzheimer’s Disease Therapeutic and Diagnostic Trials

20 Aug 2014 - Today, researchers at the Blanchette Rockefeller Neurosciences Institute (BRNI) announced findings from a new study entitled, “PKCe Deficits in Alzheimer’s Disease Brains and Skin Fibroblasts.” These new findings offer significant promise for a new therapeutic and diagnostic approach to Alzheimer's disease (AD) that has remained so refractory to effective and early drug treatment. This approach is now the major focus of ongoing clinical trials being conducted by at BRNI/Neurotrope, Inc. collaboration. In contrast to past strategies, this new therapeutic strategy now being clinically tested, not only removes the precursors to amyloid plaques and tangles, it also induces the growth of new synapses and prevents neuronal death. ...

Drexel University College of Medicine Research May Lead to Improved Alzheimer’s/ Vascular Dementia Diagnostic Guidelines

14 Aug 2014 - Alzheimer’s disease (AD) and vascular dementia (VaD) are the most common forms of dementia. Traditionally, these illnesses have been treated as separate clinical syndromes. But new research led by Drexel University College of Medicine suggests that AD and VaD have much more in common than diagnostic guidelines currently allow. The study is set for publication in the September edition of the Journal of Alzheimer’s Disease....

Decline in Daily Functioning Related to Decreased Brain Activity in Early Stages of Alzheimer’s Disease

12 Aug 2014 - Decline in daily functioning associated with Alzheimer’s disease is related to alterations in activity in certain regions of the brain, according to a study published in the August 2014 issue of the Journal of Alzheimer’s Disease. ...

Dementia Risk Quadrupled in People with Mild Cognitive Impairment

07 Aug 2014 - In a long-term, large-scale population-based study of individuals aged 55 years or older in the general population researchers found that those diagnosed with mild cognitive impairment (MCI) had a four-fold increased risk of developing dementia or Alzheimer’s disease (AD) compared to cognitively healthy individuals. Several risk factors including older age, positive APOE-ɛ4 status, low total cholesterol levels, and stroke, as well as specific MRI findings were associated with an increased risk of developing MCI. The results are published in a supplement to the Journal of Alzheimer’s Disease. ...

JAD Leads the Field in New Study of More Than 6 Decades of AD Literature

06 Aug 2014 - There have been several studies mapping out Alzheimer’s disease (AD) research using bibliometrics. One of these studies was instrumental in building the Top 100 Most Prolific AD Investigators and Top 100 Most Cited AD Investigators lists that you’ll find on the JAD website....

Study disproves link between lyme disease and alzheimer’s

18 Jul 2014 - New research from the University of Toronto Mississauga definitively puts to rest a theory that Lyme disease causes Alzheimer’s....

Symptoms of depression predict dementia

17 Jul 2014 - People who develop a combination of mild cognitive problems and depressive symptoms in old age are more likely to develop Alzheimer’s than are their age peers with mild cognitive disorders and no symptoms of depression. This was the conclusion of a study conducted at the University of Antwerp, in which scientists followed a large group of elderly people with mild cognitive impairment. The study is appearing in a leading publication, the Journal of Alzheimer’s Disease....

Cocoa Extract May Counter Specific Mechanisms of Alzheimer’s Disease

25 Jun 2014 - A specific preparation of cocoa-extract called Lavado may reduce damage to nerve pathways seen in Alzheimer’s disease patients’ brains long before they develop symptoms, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published June 20 in the Journal of Alzheimer’s Disease (JAD). ...

Bob Olsson, PhD, Wins 2014 Alzheimer Award

28 May 2014 - We are proud to announce that Bob Olsson, PhD, has been chosen as the recipient of the 2014 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on microglia markers and Alzheimer’s disease....

Compound Reverses Symptoms of Alzheimer’s Disease in Mice, SLU Research Shows

21 May 2014 - A molecular compound developed by Saint Louis University scientists restored learning, memory and appropriate behavior in a mouse model of Alzheimer’s disease, according to findings in the May issue of the Journal of Alzheimer’s Disease. The molecule also reduced inflammation in the part of the brain responsible for learning and memory....

Study: Testosterone therapy can damage brain health in Caucasian men

06 May 2014 - Ads touting testosterone replacement therapy are ubiquitous on radio and television. But medical research has determined that its success at enhancing libido may come at a price....

No Evidence of AD-Associated Changes in Adolescents Carrying Genetic Risk Factors

09 Apr 2014 - Two studies published in the Journal of Alzheimer’s Disease indicate that some of the pathologic changes associated with Alzheimer’s disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease. In the first study, no differences were found in hippocampal volume or asymmetry between cognitively normal adolescent carriers and non-carriers of the ApoE ɛ4 or ɛ2 allelles. The second study reports no differences in plasma concentrations of amyloid-β peptides among young adult ɛ4, ɛ3 or ɛ2 carriers....

New Therapeutic Target Discovered for Alzheimer’s Disease

19 Mar 2014 - A team of scientists from the University of California, San Diego School of Medicine, the Medical University of South Carolina and San Diego-based American Life Science Pharmaceuticals, Inc., report that cathepsin B gene knockout or its reduction by an enzyme inhibitor blocks creation of key neurotoxic pGlu-Aβ peptides linked to Alzheimer’s disease (AD). Moreover, the candidate inhibitor drug has been shown to be safe in humans....

SDSC/UC San Diego Researchers Hone in on Alzheimer’s Disease

21 Feb 2014 - Researchers studying peptides using the Gordon supercomputer at the San Diego Supercomputer Center (SDSC) at the University of California, San Diego (UCSD) have found new ways to elucidate the creation of the toxic oligomers associated with Alzheimer’s disease. ...

Neuropsychological assessment more efficient than MRI for tracking disease progression in memory clinic patients

19 Feb 2014 - Investigators at the University of Amsterdam, The Netherlands, have shown that progression of disease in memory clinic patients can be tracked efficiently with 45 minutes of neuropsychological testing. MRI measures of brain atrophy were shown to be less reliable to pick up changes in the same patients. ...

2014 Neuroscience Neurology Brochure

31 Jan 2014 - Download the 2014 Neuroscience Neurology Brochure here. ...

Study Reveals Buildup of Amyloid in Brain Blood Vessels Promotes Early Cognitive Impairment

02 Jan 2014 - A team of Stony Brook University researchers led by William Van Nostrand, PhD, Professor in the Department of Neurosurgery, has discovered in a model of Alzheimer’s disease that early accumulation of a small protein, known as amyloid β, in the blood vessels of the brain can drive early cognitive impairment. The findings, published in the current online edition of the Journal of Alzheimer’s Disease, suggest that targeting early buildup of amyloid in brain blood vessels could be a potential treatment strategy in early stage disease. ...

Lifestyle holds key to predicting women’s brain health

19 Dec 2013 - Australian researchers have identified lifestyle factors that impair women’s brain performance as early as age 45....

UA Study Shows Intensive Exercise Training Program Designed for Dementia Patients Improves Care in Clinical Setting

19 Dec 2013 - A study by researchers at the University of Arizona Department of Surgery published in the Journal of Alzheimer's Disease showed an innovative, customized exercise program applied to clinical practice substantially improved care for dementia patients....

A research team finds a method to predict Alzheimer's disease within two years of screening

03 Dec 2013 - At the first signs of memory loss, most people start worrying and wonder, “What if I have Alzheimer's disease?” And yet, the disease is often diagnosed late in its development and sometimes up to ten years after the first pathological changes have affected the brain. A major goal in the treatment of Alzheimer's disease has been to provide earlier diagnosis so that patients can receive treatment as early as possible. A study by Sylvie Belleville, PhD, Director of Research at the Institut universitaire de gériatrie de Montréal, an institution affiliated with Université de Montréal, has shown a way to do just that. In their study, Sylvie Belleville and her team accurately predicted (at a rate of 90%) which of their research subjects with mild cognitive impairment would receive a clinical diagnosis of Alzheimer's disease within the following two years and which subjects would not develop this disease. The study was published in Volume 38, Issue 2 of the prestigious Journal of Alzheimer's Disease. ...

Prescription of anti-Alzheimer medications to persons with mild cognitive impairment (MCI) is low in France

15 Nov 2013 - In France prescription of drugs for Alzheimer’s disease (AD) is strictly regulated. The Department of Public Health and the Memory Clinic of Nice University Hospital have explored real world prescriptions of anti-AD medications in patients with mild cognitive impairment (MCI) not AD. A national survey [1] was set up from the data of the French National Alzheimer Databank (BNA) and shows that off label prescriptions are not frequent and concern 6.1% of MCI patients (versus a quarter of MCI patients in the US [2]). French physicians seem to limit this kind of prescription to MCI patients at risk of conversion to AD: more aged, with a more important quantitative cognitive impairment and with a memory predominant form. In a context of low efficacy of the available medications against AD this study emphasizes the need to develop more preventive drugs....

New Method Predicts Time from Alzheimer’s Onset to Nursing Home, Death

08 Nov 2013 - A Columbia University Medical Center-led research team has clinically validated a new method for predicting time to full-time care, nursing home residence, or death for patients with Alzheimer’s disease. The method, which uses data gathered from a single patient visit, is based on a complex model of Alzheimer’s disease progression that the researchers developed by consecutively following two sets of Alzheimer’s patients for 10 years each. The results were published online ahead of print in the Journal of Alzheimer's Disease....

Sanders-Brown Researchers Produce New Research on Little-Understood Brain Disease

08 Nov 2013 - As the population of older adults continues to grow, researchers at the University of Kentucky Sanders-Brown Center on Aging are engaged in work to understand the mechanisms of a variety of diseases that predominately affect those of advanced age....

A Potential New Strategy to Face Dementia

08 Oct 2013 - Alzheimer’s disease (AD) affects millions of people worldwide. As a result of an increase in life expectancy, the number of patients with dementia is expected to increase dramatically. Due to the lack of effective treatments that can slow down or reverse the progression of AD, preventive measures to lower the prevalence rate of AD by means of managing potential or actual risk factors is a reasonable clinical strategy. In this respect, identifying treatable factors which are able to promote cognitive deterioration would have important practical implications....

Novel accelerometer-based algorithm detects early signals of Alzheimer’s disease in everyday motion behavior

08 Oct 2013 - The projected substantial increase in Alzheimer’s disease due to the higher life expectancy in modern societies is one of the great future challenges of health care systems worldwide. Alzheimer’s disease leads to significant changes in the temporal structure of activities that impair everyday activities. Abnormal motion behavior and degeneration of the sleep-waking cycle are among the most severe behavioral symptoms. An early detection and even a prediction of these behaviors would allow a timely onset of interventions that aim to delay the manifestation or exacerbation of symptoms and reduce the need of institutionalized care....

Changing to the Western diet increases risk of Alzheimer's disease

25 Sep 2013 - In a paper just published electronically in the Journal of Alzheimer’s Disease, dramatic increases in Alzheimer’s disease (AD) in Japan and significant increases in developing countries are linked to changes in national diets....

UCLA study suggests iron is at core of Alzheimer's disease

26 Aug 2013 - Alzheimer's disease has proven to be a difficult enemy to defeat. After all, aging is the No. 1 risk factor for the disorder, and there's no stopping that. ...

Breastfeeding may reduce Alzheimer’s risk

08 Aug 2013 - Mothers who breastfeed their children may have a lower risk of developing Alzheimer’s Disease, with longer periods of breastfeeding also lowering the overall risk, a new study suggests....

Exercise May be the Best Medicine for Alzheimer’s Disease, UMD Study Shows

07 Aug 2013 - New research out of the University of Maryland School of Public Health shows that exercise may improve cognitive function in those at risk for Alzheimer’s by improving the efficiency of brain activity associated with memory. Memory loss leading to Alzheimer’s disease is one of the greatest fears among older Americans. While some memory loss is normal and to be expected as we age, a diagnosis of mild cognitive impairment, or MCI, signals more substantial memory loss and a greater risk for Alzheimer’s, for which there currently is no cure. ...

Poor dental health may lead to Alzheimer’s, study suggests

01 Aug 2013 -

People with poor oral hygiene or gum disease may be at a greater risk of developing Alzheimer’s disease, a new study led by The University of Central Lancashire (UCLan) School of Medicine and Dentistry suggests.

The research, which has received international collaboration, and led by Professor Stjohn Crean and Dr Sim Singhrao from UCLan, examined brain samples donated by ten patients without dementia and ten patients suffering from dementia. The research demonstrated the presence of products from Porphyromonas gingivalis in brains from patients suffering from dementia.

This bacterium is commonly associated with chronic periodontal (gum) disease. These bacteria enter the bloodstream through daily activities such as eating, chewing, tooth brushing but especially following invasive dental treatment, and from there, potentially enter the brain on a regular basis. The researchers propose that every time they reach the brain, the bacteria may trigger immune system responses by already primed brains cells, causing them to release more chemicals that kill neurons. This could be one mechanism that leads to changes in the brain, which is typical of Alzheimer’s disease, and could be responsible for causing symptoms such as confusion and deteriorating memory.

The research benefited from donated brain samples, provided by Brains for Dementia Research, a brain donation scheme supported by Alzheimer’s Research UK and Alzheimer’s Society. Finding P. gingivalis in the brains from dementia sufferers compared to those without dementia is significant as its presence in Alzheimer’s diseased brains has not been documented previously and at the same time adds to a growing body of evidence that suggests an association between poor oral health and dementia.

These published research findings from human brain specimens are further supported by recent (as yet unpublished) research from the same group, on periodontal disease, using animal models, which has been carried out in collaboration with the University of Florida. This animal work has confirmed that P. gingivalis in the mouth finds its way to the brain once the periodontal disease becomes established.

Professor Stjohn Crean, Dean, School of Medicine & Dentistry said:

“Whereas previous studies have indicated a link between dementia and other bacteria and viruses such as the Herpes simplex virus type I, this new research indicates a possible association between gum disease and individuals who may be susceptible to developing Alzheimer’s disease, if exposed to the appropriate trigger! Research currently underway at UCLan is playing an active role in exploring this link, but it remains to be proven whether poor dental hygiene can lead to dementia in healthy people, which obviously could have significant implications for the population as a whole.  It is also likely that these bacteria could make the existing disease condition worse.”

Dr. Sim K. Singhrao, Senior Research Fellow at UCLan said: “We are working on the theory that when the brain is repeatedly exposed to bacteria and/or their debris from our gums, subsequent immune responses may lead to nerve cell death and possibly memory loss. Thus, continued visits to dental hygiene professionals throughout one’s life may be more important than currently envisaged with inferences for health outside of the mouth only. To help us prove our hypothesis we are hoping to use the Brains for Dementia Research tissue resource to examine brain tissue from people with both intact and compromised memory who have relevant dental records. The future of the research aims to discover if P. gingivalis can be used as a marker, via a simple blood test, to predict the development of Alzhiemer’s disease in at risk patients.” 

Notes to editors:

The University of Central Lancashire (UCLan), with Professor Lakshmyya Kesavalu who specialises in animal models of periodontal disease (Department of Periodontology and Oral Biology, College of Dentistry, University of Florida, USA).

The University of Central Lancashire (UCLan) has developed an enviable reputation as an institution that innovates, evolving its course portfolio to over 500 undergraduate programmes and 180 postgraduate courses. The University has an established research reputation within the areas of Business, Health, Humanities and Science. In the recent Research Assessment Exercise, all 17 subject areas submitted were rated as containing research of international excellence while 11 areas were assessed to be undertaking research which is world-leading. With approximately 32,000 students, the University indirectly contributes close to £250 million into the regional economy every year. UCLan is currently in the process of spending more than £120 million on new buildings and facilities to support teaching, learning and leisure activities.

Brains for Dementia Research is a partnership between the Alzheimer’s Research UK and Alzheimer’s Society to promote brain donation and develop a network of brain tissue banks in England and Wales for dementia research. The project is being run in association with the Medical Research Council. The Brains for Dementia Research coordinating centre is based at King’s College London and there are six assessment and donation centres based at the Universities of Cardiff, London, Manchester, Newcastle, Oxford and Bristol. 

For more information contact:

Natasha Gandhi
PR Officer - University of Central Lancashire
T:  0207 067 0295   
E:  ngandhi@webershandwick.com

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue. Sophie Poole, Sim K. Singhrao, Lakshmyya Kesavalu, Michael A. Curtis, St John Crean. Journal of Alzheimer's Disease, DOI 10.3233/JAD-121918. Published by IOS Press.

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Ineke van Rossum, MD, Receives 2013 Alzheimer Award

01 Jul 2013 - Ineke van Rossum, MD, has been chosen as the recipient of the 2013 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of her outstanding work that implicates a different role for biomarkers in the diagnosis and prognosis of subjects with mild cognitive impairment due to Alzheimer’s disease....

New Alzheimer’s research suggests possible cause: the interaction of proteins in the brain

26 Jun 2013 - For years, Alzheimer's researchers have focused on two proteins that accumulate in the brains of people with Alzheimer's and may contribute to the disease: plaques made up of the protein amyloid-beta, and tangles of another protein, called tau....

Alzheimer's Leaves Clues in Blood

05 Jun 2013 - Alzheimer researchers in Spain have taken a step closer to finding a blood test to help in the diagnosis of Alzheimer’s disease. ...

UC Santa Barbara Scientists Discover Cinnamon Compounds’ Potential Ability to Prevent Alzheimer’s

29 May 2013 - Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important health benefit? The common baking spice might hold the key to delaying the onset of — or warding off — the effects of Alzheimer’s disease....

UCLA brain-imaging tool and stroke risk test help identify cognitive decline early

04 Apr 2013 - UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia. ...

Probable amnestic MCI people are in the highest risk of conversion to dementia

05 Mar 2013 - People with probable amnestic mild cognitive impairment (MCI) have the most and closest risk of conversion to dementia, mainly Alzheimer’s disease (AD), according to a recent research of Fundació ACE, Barcelona Alzheimer Treatment and Research Center (www.fundacioace.com). That is, amnestic MCI subjects without any comorbidity that could explain their cognitive deficits have 8.5 times more risk to convert to dementia than people with non-amnestic MCI caused by cerebrovascular pathology or psycho-affective symptoms. Furthermore, a storage pattern of memory impairment, the multiple domain condition, and the presence of at least one ε4 allele increase the risk of conversion to dementia in MCI subjects. ...

Most U.S. neurologists plan to use new brain scan for Alzheimer’s detection

14 Feb 2013 - A large majority of the nation's top neurologists say they would use a recently approved amyloid detection brain scan to evaluate their patients for Alzheimer's disease if the scan was paid for by health insurance, according to a survey recently published in the Journal of Alzheimer's Disease....

Vitamin D, omega-3 may help clear amyloid plaques found in Alzheimer's

07 Feb 2013 - A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system's ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer's disease. ...

Exercise can slow onset of Alzheimer’s memory loss — scientists identify link

28 Jan 2013 - Keeping active can slow down the progression of memory loss in people with Alzheimer’s disease, a study has shown. A team of researchers from The University of Nottingham has identified a stress hormone produced during moderate exercise that may protect the brain from memory changes related to the disease. The work, funded by Research into Ageing (Age UK) and the University and published in the Journal of Alzheimer’s Disease, may also explain why people who are susceptible to stress are at more risk of developing the disease. ...

Method developed by VTT targets diagnosis of early Alzheimer’s disease

05 Dec 2012 - A software tool called PredictAD developed by VTT Technical Research Centre of Finland promises to enable earlier diagnosis of the disease on the basis of patient measurements and large databases. Alzheimer’s disease currently takes on average 20 months to diagnose in Europe. VTT has shown that the new method could allow as many as half of patients to get a diagnosis approximately a year earlier....

2013 Neuroscience Neurology Brochure

27 Nov 2012 - Download the 2013 Neuroscience Neurology Brochure here. ...

Controlling Vascular Disease May Be Key to Reducing Prevalence of Alzheimer’s Disease

06 Nov 2012 - Over the last 15 years, researchers have found a significant association between vascular diseases such as hypertension, atherosclerosis, diabetes type 2, hyperlipidemia, and heart disease and an increased risk of Alzheimer’s disease. In a special issue of the Journal of Alzheimer’s Disease, leading experts provide a comprehensive overview of the pathological, biochemical, and physiological processes that contribute to Alzheimer’s disease risk and ways that may delay or reverse these age-related abnormalities....

New Diagnostic Biomarkers Offer Ray of Hope for Alzheimer’s Disease

30 Aug 2012 - Alzheimer’s disease (AD) is one of the most common brain disorders, with an estimated 35 million people affected worldwide. In the last decade, research has advanced our understanding of how AD affects the brain. However, diagnosis continues to rely primarily on neuropsychological tests which can only detect the disease after clinical symptoms begin. In a supplement to the Journal of Alzheimer’s Disease, investigators report on the development of imaging-based biomarkers that will have an impact on diagnosis before the disease process is set in motion. ...

Tai Chi Increases Brain Size and Benefits Cognition in Randomized Controlled Trial of Chinese Elderly

20 Jun 2012 - Scientists from the University of South Florida and Fudan University in Shanghai found increases in brain volume and improvements on tests of memory and thinking in Chinese seniors who practiced Tai Chi three times a week, reports an article published today in the Journal of Alzheimer’s Disease. ...

Link between Metabolic Disorders and Alzheimer’s Disease Examined

15 Jun 2012 - No effective treatments are currently available for the prevention or cure of Alzheimer’s disease (AD), the most frequent form of dementia in the elderly. The most recognized risk factors, advancing age and having the apolipoprotein E Ɛ4 gene, cannot be modified or treated. Increasingly, scientists are looking toward other risk factors to identify preventive and therapeutic strategies. Much attention recently has focused on the metabolic syndrome (MetS), with a strong and growing body of research suggesting that metabolic disorders and obesity may play a role in the development of dementia. ...

Drink coffee to avoid Alzheimer's Disease: study shows older adults benefit

06 Jun 2012 - Research shows drinking coffee can avoid the onset of Alzheimer's Disease in people over 65 years old. ...

Scientists Reveal Early Diagnostic Clues for Alzheimer’s Disease Using Advanced Brain Imaging Technology

03 May 2012 -

Alzheimer's disease (AD) is a major neurodegenerative disorder that affects millions of people worldwide. New and accurate techniques for early diagnosis are critical. Pravat K. Mandal, PhD, and his colleagues have developed a completely non-invasive brain imaging technique to measure specific brain chemical changes. This provides a signature of the early stages of AD from the hippocampal region of the brain. Their work is reported in the Journal of Alzheimer’s Disease.
    
“Alzheimer’s disease has become a silent tsunami in the aging population,” says Dr. Mandal, who is associated with the National Brain Research Center, Gurgaon, India, and Johns Hopkins University School of Medicine.  “This discovery of a diagnostic technique that requires no blood work or radiation, and that can be conducted in less than fifteen minutes, may offer hope to Alzheimer’s disease patients and their families.”

Dr. Mandal and his co-investigators studied the brains of normal controls, AD patients, and patients with mild cognitive impairment (MCI) using multi-voxel 31P magnetic resonance spectroscopy (MRS) imaging, along with an advanced analytical tool, to assess brain chemistry in the hippocampal regions.  They observed during the course of their study that the left hippocampus becomes alkaline in AD patients, which is in contrast to the normal aging process in which the brain tends to be more acidic.  

Dr. Mandal and his colleagues also identified four brain chemicals that change significantly in pre-Alzheimer and Alzheimer disease patients compared to normal subjects.  They are phosphomonoester (PME), the building block of neuronal membrane; phosphodiester (PDE), the membrane degradation product; phosphocreatine (PCr), stored energy for brain functioning; and adenosine triphosphate (-ATP), the source of brain energy.  The level of PME is significantly decreased in the left hippocampal areas of these patients, and the levels of PDE, PCr, and -ATP are increased.  

“In the left hippocampus the increase in pH to the alkaline range, along with statistically significant increases in PDE, PCr, and y-ATP and decreases in PDE, serve as a promising new biomarker for AD,” notes Dr. Mandal.  He and his colleagues plan to conduct longitudinal studies with Alzheimer and Parkinson patients with larger sample sizes to investigate specificity of their test.  “It is our hope that such clinical research, using state-of-the-art technology, may give new hope to cognitively impaired patients for an earlier and more predictable AD diagnosis.”   

These clinical studies were performed in collaboration with Dr. Manjari Tripathi, MD, DM, Department of Neurology, All India Institute of Medical Sciences, New Delhi. This study was made possible through the research funding, to Dr. Mandal, from the Department of Biotechnology, Government of India.

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Mapping of Hippocampal pH and Neurochemicals from in vivo Multi-Voxel 31P Study in Healthy Normal Young Male/Female, Mild Cognitive Impairment, and Alzheimer’s Disease,” by Pravat K. Mandal, Himanshu Akolkar and  Manjari Tripathi. Journal of Alzheimer’s Disease, Volume 31 (2012), Supplement 3, DOI 10.3233/JAD-2012-120166.

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Anders Lönneborg, PhD, Receives 2012 Alzheimer Award

02 May 2012 -

Anders Lönneborg, PhD, has been chosen as the recipient of the 2012 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on the detection of early Alzheimer’s disease.

“My co-authors and I are extremely pleased to have been chosen by a distinguished group of peers as the recipients of this year’s Journal of Alzheimer’s Disease award for our work on the development of ADtect®, the 96-gene expression test for detection of early Alzheimer’s disease,” said Dr. Lönneborg, Research Director, DiaGenic, Oslo, Norway.

Each year the more than 500 Associate Editors of the Journal of Alzheimer’s Disease vote to select an outstanding article published the previous year to receive this prestigious award, which is made possible by support from IOS Press and Elan Pharmaceuticals. Dr. Lönneborg will be presented with the bronze Alzheimer Medal featuring the likeness of Alois Alzheimer. The winning paper is entitled, “A Novel Blood Test for the Early Detection of Alzheimer’s Disease" (J Alzheimers Dis 23, 121-129, 2011), by A. Lönneborg et al.

The team behind the paper, led by Dr. Lönneborg, investigated the diagnostic value of a 96-gene expression array for detection of early AD. A disease classification algorithm was developed and was validated in two steps using an independent initial test set and another second test set. A similar accuracy (72%), sensitivity (72%) and specificity (71%) were achieved both in the initial analysis and in the two independent test sets. When compared with available CSF biomarker data high agreement (80%) was found.

“Although further studies are needed to confirm these findings, they suggest that the gene expression test using a convenient blood sample can aid the diagnosis of mild to moderate AD,” adds Dr. Lönneborg.

Anders Lönneborg, PhD, received his degree in molecular plant physiology from the University of Umeå, Sweden in 1986. After a postdoctoral fellowship in molecular plant biology at Michigan State University under the mentorship of Prof. Chris Somerville, and working as Research Scientist at the Norwegian University of Life Sciences and as Senior Scientist at the Norwegian Forest Research Institute, Dr. Lönneborg was acknowledged competence as professor in 1995. In 1998 he founded DiaGenic with Dr. Praveen Sharma, where he has served as Research Director since the company’s inception and CEO from 2003-2007.

DiaGenic’s focus has always been to develop blood-based tests based on gene expression to aid the diagnosis of important diseases, primarily neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease. The company aims to develop companion diagnostics and biomarkers to aid the development of novel treatments for Alzheimer’s disease.

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