Journal of Alzheimer’s Disease

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JAD_13
impact factor 2016 3.920
ISSN print
1387-2877
ISSN online
1875-8908
Volume
49-54; 24 issues
Status
Last issue (55:2) online on 22 November 2016
Next issue
55:3 scheduled for March 2017
Back volumes
1-48
Website
www.j-alz.com
Subject
Biochemistry, Medicine & Health, Neurosciences
Institutional subscription for 2017 €2470 / US$3200 Excluding VAT
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Alzheimer Funding Analyzer Launched on Journal of Alzheimer’s Disease Website

The Journal of Alzheimer’s Disease (JAD) is proud to announce the launch of the Alzheimer’s Funding Analyzer (AFA) on the JAD website. It is a free service that is part of a new suite of online features that have been designed to serve the needs of the Alzheimer disease (AD) research community.

The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer’s disease.

In Remembrance of Editor-in-Chief Mark A. Smith

Editor-in-Chief
George Perry, PhD
College of Sciences
University of Texas at San Antonio
One UTSA Circle
San Antonio, Texas 78249, USA
Email: george.perry@utsa.edu
Tel: +1.210.458.4450
Fax:+1.210.458.4445

Managing Editor
Beth Kumar
Department of Pathology
Case Western Reserve University
2103 Cornell Road
Cleveland, Ohio 44106, USA
Email: editorial@j-alz.com
Tel:+1.216.368.3671
Fax:+1.216.368.8964

Deputy Editor
Jesus Avila

Deputy Editor
Xiongwei Zhu

Deputy Editor
Massimo Tabaton

Scientometrics Editor
Aaron A. Sorensen

Former Editor-in-Chief, 2001-2010
Mark A. Smith, PhD

Senior Editors
Jose Abisambra
Maheen Mausoof Adamson
Paula Agostinho
Gary Arendash
Beatrice Arosio
J. Wesson Ashford
Jason Brandt
Paulo Caramelli
Jack C. de la Torre
Sebastiaan Engelborghs
Daniela Galimberti
Debomoy Lahiri
Piotr Lewczuk
Patrizia Mecocci
Francesco Panza
Sang Won Seo
Thomas Shea
Lan Tan
Jin-Tai Yu
Henrik Zetterberg

Associate Editors
Please find the full list of the Associate Editors at http://j-alz.com/board.

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Aurin Biotech’s Simple Saliva Test Predicts Future Onset Of Alzheimer’s Disease

28 Nov 2016 - Aurin Biotech (aurinbiotech.com), announced that it has developed a simple saliva test that can diagnose Alzheimer’s disease, as well as predict its future onset, allowing individuals to take preventive measures before the disease takes hold. ...

New Study Shows Marijuana Users have Low Blood Flow to the Brain

28 Nov 2016 - As the U.S. races to legalize marijuana for medicinal and recreational use, a new, large scale brain imaging study gives reason for caution. Published in the Journal of Alzheimer’s Disease, researchers using single photon emission computed tomography (SPECT), a sophisticated imaging study that evaluates blood flow and activity patterns, demonstrated abnormally low blood flow in virtually every area of the brain studies in nearly 1,000 marijuana compared to healthy controls, including areas known to be affected by Alzheimer’s pathology such as the hippocampus....

UTMB study offers new insight into how Alzheimer’s disease begins

24 Nov 2016 - A new study from The University of Texas Medical Branch at Galveston offers important insight into how Alzheimer’s disease begins within the brain. The researchers found a relationship between inflammation, a toxic protein and the onset of the disease. The study also identified a way that doctors can detect early signs of Alzheimer’s by looking at the back of patients’ eyes....

A Novel and Intelligent Home Monitoring System for Care Support of Elders with Cognitive Impairment

31 Oct 2016 - Greek researchers demonstrated the potential use of assistive technologies for people with dementia, to fulfill an important need: the improvement of clinical diagnosis and decision making meeting individual needs. ...

Study Demonstrates Mass Spectrometry Technique Dramatically Enhances Detection of Key Early Stage Alzheimer’s Biomarkers

12 Oct 2016 - A peer reviewed study led by Proteome Sciences plc (“Proteome Sciences”), in conjunction with a group of highly respected universities and hospitals, demonstrates the ability of an innovative mass spectrometry (MS) workflow to dramatically improve the ability to detect tau-derived peptides that are directly related to human Alzheimer’s pathology as early stage biomarkers of the disease....

Online advice for preventing Alzheimer’s disease often problematic: UBC research

11 Oct 2016 - New UBC research finds that many online resources for preventing Alzheimer’s disease are problematic and could be steering people in the wrong direction....

Specific Triazine Herbicides Induce Amyloid-β42 Production

15 Sep 2016 - A new study led by Laurent Meijer, at ManRos Therapeutics, and collaborators shows that some herbicides (triazines) trigger enhanced in vitro production of the Aβ42 over Aβ40 amyloid peptides in various cell lines. This suggests that some products from the ‘human chemical exposome’ (HCE) (estimated to be over 85,000 products) may contribute to the increased production of Aβ42 over Aβ40 characteristic of Alzheimer’s disease (AD). In addition, some of these products might be turned into pharmacological tools to develop a chemically-induced animal model of AD (in contrast with the currently used genetic, recombinant mice models). Publication of these findings is scheduled in the Journal of Alzheimer's Disease, vol. 54(4) issue. This work is now continuing with special focus on (1) Persistent Organic Pollutants (POPs) and (2) defining conditions under which such products could trigger in vivo Aβ42 production in mice....

Markers associated with Alzheimer’s and Parkinson’s diseases are present in Mexico City children chronically exposed to concentrations of fine particulate matter PM2.5 above the current EPA USA standards

12 Sep 2016 - A new study by researchers at the Universities of Montana, Valle de México, Boise State, Veracruz University, Médica Sur, Centro de Ciencias de la Atmósfera, UNAM, Hospital Regional de Alta Especialidad, Ciudad Victoria, Hospital de Especialidades #14, IMSS, Centre Hospitalier Universitaire, Hôpital de Hautepierre and AJ Roboscreen GmbH heightens concerns over the detrimental impact of fine particulate matter PM2.5 on CSF markers associated with Alzheimer and Parkinson’s diseases in children ages 11.9±4.8 years. These findings are published in the Journal of Alzheimer’s Disease....

Efficacy and Safety of Crocus Sativus L in Patients with Mild Cognitive Impairment: One Year Single-Blind Randomized, with Parallel Groups, Clinical Trial

12 Sep 2016 - Greek researchers and clinicians demonstrated the potential of Crocus Sativus L. (saffron) as a therapeutic pharmaceutical natural compound for older adults with amnestic Mild Cognitive Impairment (aMCI). MCI is a condition that often predates Alzheimer’s disease (AD) and is characterized by memory loss and inability to execute complex Activities of Daily Living. While there is no treatment for MCI and symptomatic only treatment for AD, the global effort against cognitive disorders is focused on early detection and management of AD at the stage of MCI....

Midlife physical activity is associated with better cognition in old age

12 Sep 2016 - A long-term follow-up study of 3050 twins from the Finnish Twin Cohort has shown that midlife, moderately vigorous physical activity is associated with better cognition at old age. The association was statistically independent of midlife hypertension, smoking, education level, sex, obesity and binge drinking. This suggests that the beneficial influence of physical activity on the brain and cognition is not solely based on decreasing vascular risk factors. ...

Subjective Cognitive Decline and risk of future AD dementia - results from a German multi-center study highlights the importance of temporal consistency

07 Sep 2016 - A new study, based on longitudinal data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe), suggests that temporal stability versus instability of an individual’s report of subjective worsening of cognition over time plays an important role with regard to whether such experiences are associated with future dementia risk. These findings, which will be published in the Journal of Alzheimer's Disease 54(3), add to a constantly growing strand of research on the phenomenon of “Subjective Cognitive Decline” (SCD) in Alzheimer’s Disease (AD). ...

BU Study Reveals Association between Physical Function and Neurological Disease

25 Aug 2016 - A new study, based on data from the Framingham Heart Study (FHS) suggests a simple test of physical functioning may be able to help physicians identify individuals who are at a higher risk for developing Alzheimer’s disease and stroke....

Current Screening Methods Miss Worrisome Number of Persons with Mild Cognitive Impairment

02 Aug 2016 - Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer’s disease or another type of dementia....

Artistic Skills Emerge as Dementia Progresses

28 Jul 2016 - A new study by researchers at Neuroscience Research Australia (NeuRA) has identified the emergence of positive changes that occur after a person has been diagnosed with dementia....

Deep Brain Stimulation continues to show promise for patients with mild Alzheimer’s disease

21 Jul 2016 - New findings published today by a team of researchers led by Dr. Andres Lozano at the Krembil Neuroscience Centre (KNC) of Toronto Western Hospital (TWH) have provided further insight into the effects of Deep Brain Stimulation (DBS) in the treatment of Alzheimer’s disease....

Driving ability of people with cognitive impairment difficult to assess: research review

19 Jul 2016 - No single assessment tool is able to consistently determine driving ability in people with Alzheimer’s disease and mild cognitive impairment, a St. Michael’s Hospital research review has found....

Mark W. Bondi, PhD, Recipient of 2016 Alzheimer Award

15 Jul 2016 - The Journal of Alzheimer’s Disease (JAD) is pleased to announce that Mark W. Bondi, PhD, ABPP/CN, Professor of Psychiatry at UC San Diego and Director of the Neuropsychological Assessment Unit at the VA San Diego Healthcare System, has been chosen as the recipient of the 2016 Alzheimer Award presented by the journal in recognition of his outstanding work on the development of a novel and promising method of staging preclinical Alzheimer’s disease (AD) based on number of abnormal biomarkers that is predictive of progression to mild cognitive impairment (MCI) and AD....

Estrogen Patch in Newly Postmenopausal Women May Reduce Alzheimer’s Risk

14 Jul 2016 - Can estrogen preserve brain function and decrease the risk of Alzheimer’s disease when given early in menopause? Newly postmenopausal women who received estrogen via a skin patch had reduced beta-amyloid deposits, the sticky plaques found in the brains of people with Alzheimer’s disease, a Mayo Clinic study published this month in the Journal of Alzheimer’s Disease found. Ultimately, these deposits harm neurons, leading to cognitive problems. ...

IOS Press Impact Factors Continue to Rise

23 Jun 2016 - IOS Press has announced that its journal Impact Factors continue to increase, according to the 2015 Journal Citation Reports® (JCR) released by Thomson Reuters © 2016. ...

Neurocentria Publishes Peer-Reviewed Paper Showing Mechanism of Action for Its Drug that Reverses Cognitive Impairment in Humans

14 Jun 2016 - Neurocentria, Inc. announced today the publication of a scientific paper showing how its candidate drug, L­-Threonic acid Magnesium salt (L-TAMS), reverses cognitive impairment in humans, as previously demonstrated. The paper titled "Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration" was published in the medical journal Neuropharmacology. The drug's discovery is based on more than a decade of research at Stanford, Tsinghua University, and MIT....

Genetic Risk of Alzheimer’s Disease Associated with Changes in Brain Metabolism in Young Adults

30 May 2016 - A team of investigators at Midwestern University, an affiliate institution of the Arizona Alzheimer’s Consortium, now report that young adult brain donors who carried a common genetic risk factor for Alzheimer’s disease showed large changes in pathways involving the uptake and use of sugars and ketone bodies — the primary sources of energy for the brain. The average age of the donors was approximately 30, well before any sign of the microscopic abnormalities commonly associated with the disease commonly appear, and almost five decades before the age at which they might develop symptoms....

Abnormally Low Blood Flow Indicates Damage to NFL Players’ Brains

26 Apr 2016 - The discovery of brain pathology through autopsy in former National Football League (NFL) players called chronic traumatic encephalopathy (CTE) has raised substantial concern among players, medical professionals, and the general public about the impact of repetitive head trauma. Using sophisticated neuroimaging and analytics, researchers have now identified abnormal areas of low blood flow in living professional football players. These findings, published in the Journal of Alzheimer’s Disease, raises the potential for better diagnosis and treatment for persons with football related head trauma....

Simple Mind-Body Therapies Shown to Improve Subjective Cognitive Decline, a Pre-Clinical Stage of Alzheimer’s Disease

26 Apr 2016 - Lead investigator Kim Innes, PhD, Associate Professor in the Department of Epidemiology in the WVU School of Public Health, and her team have published a new study in the Journal of Alzheimer’s Disease....

Problems finding your way around may be earliest sign of Alzheimer’s disease, study suggests

26 Apr 2016 - Long before Alzheimer’s disease can be diagnosed clinically, increasing difficulties building cognitive maps of new surroundings may herald the eventual clinical onset of the disorder, finds new research from Washington University in St. Louis....

B-School Innovation Professor Discovers Pathway between Diabetes and Alzheimer’s Disease

12 Apr 2016 - In a new paper published by The Journal of Alzheimer’s Disease, Professor Melissa Schilling, a strategy and innovation expert at the NYU Stern School of Business, uncovers a surprising new connection between diabetes and Alzheimer’s disease: hyperinsulinemia, which is most often caused by prediabetes, early or undiagnosed diabetes, or obesity, is responsible for almost half of all cases of Alzheimer’s disease....

Why do people with Alzheimer's stop recognizing their loved ones?

12 Apr 2016 - Alzheimer’s not only steals people’s memories but also their ability to recognize faces, which widens the gulf between people with this disease and their loved ones. A recent study has demonstrated that, beyond causing memory problems, Alzheimer’s disease also impairs visual face perception. This finding may help families better understand their loved one's inevitable difficulties and lead to new avenues to postpone this painful aspect of the disease. Research in this area by the team of Dr. Sven Joubert, PhD, a researcher at the Centre de recherche de l'Institut universitaire de gériatrie de Montréal of the CIUSSS du Centre-Sud-de-l’Île-de-Montréal and a professor with the Department of Psychology at Université de Montréal, has just been published in the Journal of Alzheimer’s Disease. ...

New Neuroscience & Neurology Brochure Available

01 Apr 2016 - Journals and Books...

Infrequent home computer use may be indicative of early cognitive decline

22 Mar 2016 - A new study sheds light on a powerful tool that may detect signs of Alzheimer’s disease before patients show any symptoms of cognitive decline: the home computer. ...

A New Perspective on the Possible Cause of Alzheimer's Disease: Microbes

17 Mar 2016 - A landmark Editorial issued by 33 senior scientists and clinicians from a dozen countries across the world has been published in the highly regarded peer-reviewed journal, Journal of Alzheimer's Disease. This major call for action is based on substantial evidence indicating that some microbes – a specific virus and particular bacteria – are likely major causes of the disease....

Omega-3 fatty acids shown to exert a positive effect on the aging brain

17 Mar 2016 - Researchers from Charité – Universitätsmedizin Berlin were able to show that omega-3 fatty acid supplementation improves memory function in humans. They studied the effects of supplementation with natural omega-3 fatty acids in healthy older adults over a period of six months. Results from the study, which show that supplementation leads to significant improvements in memory function, have been published in the current issue of the Journal of Alzheimer's Disease....

Some Ethnicities have a Greater Chance of Developing Alzheimer’s Disease before Age 65

15 Mar 2016 - New study published in the Journal of Alzheimer’s Disease found that African Americans, Alaskans and Hawaiians are at greater risk for early-onset Alzheimer’s Disease....

Different Kinds of Physical Activity Shown to Improve Brain Volume and Cut Alzheimer’s Risk in Half

11 Mar 2016 - A new study shows that a variety of physical activities from walking to gardening and dancing can improve brain volume and cut the risk of Alzheimer’s disease by 50%. ...

Depressive symptoms and the risk of Alzheimer’s disease in mild cognitive impairment

03 Mar 2016 - According to a community-based longitudinal study in Japan, researchers found that depressive symptoms increased the risk of Alzhemer’s disease (AD) in an amnestic mild cognitive impairment (aMCI) group, but not in a non-amnestic mild cognitive impairment (naMCI) group. Likewise, depressive symptoms increased the risk of aMCI but not naMCI in a cognitively normal group. Depressive symptoms might be a clue to finding prodromal AD in patients with a certain type of MCI....

Dementia: “Illness” Label Can Lower Mood

03 Mar 2016 - People who perceive dementia symptoms as an illness feel more negative than those who see it as an inevitable part of getting older, a new study indicates. ...

Research discovers neuroprotective protein in blood is biomarker of Alzheimer's disease

12 Feb 2016 - Medical professionals have to conduct a long series of tests to assess a patient's memory impairment and cognitive skills, functional abilities, and behavioral changes to accurately diagnose Alzheimer's disease. They also have to execute costly brain imagining scans and even, sometimes, invasive cerebral spinal fluid tests to rule out other diseases. The process is laborious at best -- and subjective at worst....

Alzheimer Funding Analyzer Launched on Journal of Alzheimer’s Disease Website

11 Feb 2016 - The Journal of Alzheimer’s Disease (JAD) is proud to announce the launch of the Alzheimer’s Funding Analyzer (AFA) on the JAD website. It is a free service that is part of a new suite of online features that have been designed to serve the needs of the Alzheimer disease (AD) research community....

Evidence of a lipid link in the inherited form of Alzheimer's disease

09 Feb 2016 - Australian researchers have found biochemical changes occurring in the blood, in the rare inherited form of Alzheimer’s disease. Changes in these fat-like substances, may suggest a method to diagnose all forms of Alzheimer’s disease before significant damage to the brain occurs....

Alzheimer’s Diagnosis Complicated by History of Reading Problems

21 Jan 2016 - Correctly diagnosing Alzheimer’s disease remains a challenge for medical professionals. Now, a new study published in the current issue of the Journal of Alzheimer’s Disease reveals a new clue to possible misdiagnosis. The study found that older adults with a history of reading problems perform similarly on some neuropsychological tests to those who show signs of mild cognitive impairment (MCI) associated with early Alzheimer’s disease. The finding, based on the results of a Stony Brook University-led research team in collaboration with Boston University School of Medicine, emphasizes the need for professionals to take into account developmental history and have a broad understanding of neuropsychological testing when interpreting the meaning of low memory test scores....

Omega-3 levels affect whether B vitamins can slow brain’s decline

19 Jan 2016 - While research has already established that B vitamin supplements can help slow mental decline in older people with memory problems, an international team have now found that having higher levels of Omega-3 fatty acids in your body could boost the B vitamins’ effect....

IOS Press partners with Kudos

12 Jan 2016 - IOS Press is happy to announce its partnership with Kudos (www.growkudos.com), an award winning service that helps researchers maximize the impact and visibility of their research. Kudos allows authors to enrich their articles with lay metadata, add links to related materials and promote their articles through the Kudos system to a wider public. From their personal dashboard, authors can track how often their articles are viewed and shared through Kudos. The service will be available to authors of all IOS Press journal articles starting the first quarter of 2016. ...

Study finds cerebrovascular disease to be major determinant of psychosis in patients with Alzheimer’s disease

08 Jan 2016 - About half of all patients with Alzheimer’s disease develop symptoms of psychosis, such as delusions or hallucinations....

Link Between Anemia and Mild Cognitive Impairment

16 Dec 2015 - In a large population-based study of randomly selected participants in Germany, researchers found that participants with anemia, defined as haemoglobin <13 g/dl in men and <12 g/dl in women, showed lower performances in verbal memory and executive functions. Furthermore, mild cognitive impairment (MCI) occurred almost twice more often in participants diagnosed with anemia. This study is published in the Journal of Alzheimer’s Disease....

Alzheimer’s disease progression linked to changing protein levels in immune system

16 Dec 2015 - New research has identified changing levels of proteins in the blood which are associated with increasing mental impairment over time in people with Alzheimer's disease. The findings could ultimately help develop new drugs for the condition, by allowing better monitoring of the effects of drugs and improvements in clinical trials....

Early stage dementia patients referred to specialists are institutionalized twice as often as those who are not, according to new study in the Journal of Alzheimer’s Disease

10 Dec 2015 - A new epidemiologic study showed that patients with early stage dementia, who had been referred to a specialist, have twice the risk of institutionalization compared to those who are not, according to a research study published in the Journal of Alzheimer’s Disease this month. The research suggested the influence of early specialist referral for dementia patients on institutionalization risk and demonstrated that the benefits of early dementia diagnosis may lead to challenging issues....

Singing is beneficial for memory and mood especially in early dementia

10 Dec 2015 - Researchers led by Dr. Teppo Särkämö at University of Helsinki, Finland have revealed that caregiver-implemented musical leisure activities, particularly singing, are cognitively and emotionally beneficial especially in the early stages of dementia. The findings could help improve dementia care and better target the use of music in different stages of dementia. The research was published today in the Journal of Alzheimer's Disease....

Reproductive history and risk of cognitive impairment in elderly women: a cross-sectional study in eastern China

12 Nov 2015 - Researchers led by Professor Jun-Fen Lin at Zhejiang Provincial Center for Disease Control and Prevention have found that reproductive history, an important modifier of estrogen exposure across women’s lifetime, is associated with risk of cognitive impairment in postmenopausal women. These findings are published in the Journal of Alzheimer’s Disease....

Changes in humour may be an early sign of dementia

12 Nov 2015 - Researchers at University College London (UCL) have revealed that a change in sense of humour could be an early sign of dementia. The findings could help improve dementia diagnosis, by highlighting changes not commonly thought to be linked to the condition. The study was funded by Alzheimer’s Research UK, the Wellcome Trust, Medical Research Council (MRC) and NIHR Queen Square Dementia Biomedical Research Unit. The research was published in the Journal of Alzheimer’s Disease on 10 November 2015. ...

No Increased Dementia Risk Found in Diagnosed Celiac Patients

11 Nov 2015 - A new and comprehensive study by investigators at the Celiac Disease Center at Columbia University Medical Center has found that celiac patients are at no increased risk for dementia before or after their diagnosis of celiac disease. ...

Blood test detects pre-Alzheimer’s in Mexican-Americans with 96 percent accuracy

11 Nov 2015 - A blood test developed at the University of North Texas Health Science Center detects pre-Alzheimer’s disease in asymptomatic Mexican-Americans with 96 percent accuracy. ...

UCI study finds jet lag-like sleep disruptions spur Alzheimer’s memory, learning loss

03 Nov 2015 - Chemical changes in brain cells caused by disturbances in the body’s day-night cycle may be a key underlying cause of the learning and memory loss associated with Alzheimer’s disease, according to a University of California, Irvine study....

Neurocentria’s Lead Compound MMFS-01 Improves Brain Age by 9 Years in Human Study on Older Adults

03 Nov 2015 - Neurocentria Inc., a clinical-stage biopharmaceutical company developing therapeutics to enhance brain function and correct cognitive impairment, announced the successful completion of a human study demonstrating that the company’s lead compound significantly reversed cognitive impairment in subjects 50 to 70 years old. The results have been published in the peer-reviewed Journal of Alzheimer's Disease....

Use of benzodiazepines and related drugs common around Alzheimer's diagnosis

22 Oct 2015 - Benzodiazepines and related drugs are initiated frequently in persons with Alzheimer's disease already before the diagnosis, and their use becomes even more common after the diagnosis, shows a recent study from the University of Eastern Finland. Benzodiazepines and related drugs are used as a sleep medication and for anxiolytic purposes. These drugs were initiated more frequently in persons with Alzheimer's disease than in persons not diagnosed with AD. Compared to persons not diagnosed with AD, it was three times more likely for persons with Alzheimer's disease to initiate benzodiazepine use after the diagnosis, and benzodiazepines were most commonly initiated six months after the diagnosis. ...

Research Study Validates Neuroreader For Accurate And Fast Measurement Of Brain Volumes

21 Oct 2015 - A new neuroimaging software, Neuroreader, was shown to be as accurate as traditional methods for detecting the slightest changes in brain volume, and does so in a fraction of the time, according to a research study published in the Journal of Alzheimer’s Disease this month. The research validates the software program that can be used for measuring hippocampal volume, a biomarker for detecting Alzheimer’s Disease. ...

Women with Alzheimer’s-related Gene Lose Weight More Sharply after Age 70 - Finding May Aid in the Treatment of Dementia

06 Oct 2015 - Brooklyn, NY – Researchers led by Deborah Gustafson, PhD, MS, professor of neurology at SUNY Downstate Medical Center, have shown that women with a gene variant (APOEe4 allele) associated with Alzheimer’s disease experience a steeper decline in body mass index (BMI) after age 70 than those women without the version of the gene, whether they go on to develop dementia or not. The finding adds to a body of evidence suggesting that body weight change may aid in the diagnosis and management of Alzheimer's disease. ...

FSU Professors Conduct Study Showing Improved Memory for Patients with Mild Cognitive Impairment When Provided with “Nutraceutical Formulation”

24 Sep 2015 - Framingham State Professor Ruth Remington, her colleague Tom Shea from UMass Lowell, and members of their research team, have published findings from a study that add to a growing body of evidence that lifestyle modification can help maintain brain power as we age....

Air pollution in Mexico City has detrimental impact on gene associated with Alzheimer’s disease, affecting parents and their children: New study

24 Sep 2015 - A new study by researchers at the Universities of Montana, Valle de México, Boise State, and North Carolina, the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Instituto Nacional de Pediatría, and Centro Médico Cozumel heightens concerns over the detrimental impact of air pollution on hippocampal metabolites as early markers of neurodegeneration in young urbanites carrying an allele 4 of the apolipoprotein E gene (APOE). This is associated with the risk for Alzheimer disease (AD) and a susceptibility marker for poor outcome in traumatic brain injury (TBI) recovery. These findings are published in the Journal of Alzheimer’s Disease....

September 21, World Alzheimer's Day - Identifying typical patterns in the progression towards Alzheimer's disease

21 Sep 2015 - How the brain progresses from mild cognitive impairment (MCI) to Alzheimer's-type dementia has been an enigma for the scientific community. However, a recent study by the team of Dr. Sylvie Belleville, PhD, Director of the Research Centre at the Institut universitaire de gériatrie de Montréal (Montreal Geriatric Institute) and Professor of Psychology at Université de Montréal, has shed light on this progression by showing the typical patterns of the brain's progression to dementia. ...

Researchers explore cocoa as novel dietary source for the prevention of cognitive deterioration in Alzheimer’s disease

15 Sep 2015 - The potential benefits of dietary cocoa extract and/or its final product in the form of chocolate have been extensively investigated in regard to several aspects of human health. Cocoa extracts contain polyphenols, which are micronutrients that have many health benefits, including reducing age-related cognitive dysfunction and promoting healthy brain aging, among others....

Researchers shed light on potential shield from Alzheimer’s

10 Sep 2015 - Today, more than 5.1 million Americans live with Alzheimer’s disease, a devastating type of dementia that plagues memory and thinking. That number is expected to triple in the coming decades. Moreover, according to a 2012 survey, Americans fear Alzheimer’s more than any other disease....

Waterford research on Alzheimer’s disease suggests that measuring macular pigment offers potential as a biomarker of cognitive health

25 Aug 2015 - Ongoing European Research Council-funded research at Waterford Institute of Technology’s (WIT) Macular Pigment Research Group (MPRG) is investigating the potential link between cognitive function and levels of a vital eye pigment linked to diet. The study suggests that measuring macular pigment offers potential as a biomarker of cognitive health. The results of this study are highlighted to a global audience through the prestigious international medical journal, the Journal of Alzheimer’s Disease. ...

Insulin’s potential to treat dementia outlined in new study

06 Aug 2015 - Researchers at the UW Medicine, Veteran's Administration Puget Sound and Saint Louis University have made a promising discovery that insulin delivered high up in the nasal cavity goes to affected areas of brain with lasting results in improving memory....

Coffee Consumption Habits Impact the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging

29 Jul 2015 - A new study by researchers at the University of Bari Aldo Moro, Bari, Italy, Geriatric Unit & Laboratory of Gerontology and Geriatrics, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Foggia, Italy, and Istituto Superiore di Sanità (ISS), Roma, Italy, estimates the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI), evaluating 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging (ILSA), a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. These findings are published in the Journal of Alzheimer’s Disease....

Alzheimer's Disease Prevention: New Journal Article Highlights Benefits of Meditation and Spiritual Fitness

27 Jul 2015 - Meditation and spiritual fitness are key components in reducing the risk of Alzheimer’s disease according to a new article, “Stress, Meditation, and Alzheimer’s Prevention: Where the Evidence Stands”, published in an early online version of the Journal of Alzheimer’s Disease 48(1). The print edition is scheduled to be published in August....

New Study Indicates Ankle-Brachial Index Associated with Mild Cognitive Impairment

23 Jul 2015 - In a large population-based study of randomly selected participants in Germany, researchers found that mild cognitive impairment (MCI) occurred significantly more often in individuals diagnosed with a lower ankle brachial index (ABI), which is a marker of generalized atherosclerosis and thus cumulative exposure to cardiovascular risk factors during lifetime. Interestingly, this strong association was only observed in patients with non-amnestic MCI, but not amnestic MCI. There also was no independent association of MCI and intima media thickness (IMT) or coronary artery calcification (CAC), two other surrogate markers of cardiovascular risk. Examination of differences by gender revealed a stronger association of a decreasing ABI with non-amnestic MCI in women. This study is published in the Journal of Alzheimer’s Disease....

Midlife High Blood Pressure May Negatively Impact the Brain Years Later

17 Jul 2015 - Having high blood pressure in your 50’s may impact your ability to keep track or plan ahead in your 80’s. ...

Affordable, Non-Invasive Test May Detect Who is Most at Risk for Alzheimer's

17 Jul 2015 - Individuals with amnestic mild cognitive impairment (aMCI) are at twice the risk of others in their age group of progressing to Alzheimer’s disease. Although no conclusive test exists to predict who will develop Alzheimer’s, new research from the Center for BrainHealth at The University of Texas at Dallas is attempting to identify a potential biomarker that could offer a more complete picture of who is most at risk....

Multiple Pathways Progressing to Alzheimer’s Disease

30 Jun 2015 - The amyloid cascade hypothesis of Alzheimer’s disease (AD) posits that sticky aggregations or plaques of amyloid-beta peptides accumulate over time in the brain, triggering a series of events that ultimately result in the full-blown neurodegenerative disorder. The hypothesis has been a major driver of AD research for more than 20 years. ...

Hartmuth Kolb, PhD, Wins 2015 Alzheimer Award

26 Jun 2015 - The Journal of Alzheimer’s Disease is proud to announce that Hartmuth Kolb, PhD, Head of Neuroscience Biomarkers, Johnson & Johnson, San Diego, CA, has been chosen as the recipient of the 2015 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on the importance and imaging of neurofibrillary tangles (NFTs) and Alzheimer’s disease (AD)....

Anti-rejection medications for transplant recipients protect against Alzheimer’s disease

11 Jun 2015 - A new study from The University of Texas Medical Branch at Galveston has revealed that a treatment taken daily by people who have had organ transplants to prevent organ rejection protects against Alzheimer’s disease. An early online version of this paper detailing the findings has been published and is scheduled for publication in the July 7 issue of the Journal of Alzheimer’s Disease....

Dementia found to decrease sexual activity

26 May 2015 - In a new study published in the Journal of Alzheimer’s Disease, Dr Rebekah Ahmed and colleagues found that patients with dementia show a decrease in sexual relations with their partners. ...

Green Tea Extract and Exercise Hinder Progress of Alzheimer’s Disease in Mice

06 May 2015 - According to the National Institutes of Health (NIH), Alzheimer’s disease (AD) may affect as many as 5.5 million Americans. Scientists currently are seeking treatments and therapies found in common foods that will help stave off the disease or prevent it completely. Now, University of Missouri researchers have determined that a compound found in green tea, and voluntary exercise, slows the progression of the disease in mice and may reverse its effects. Further study of the commonly found extract could lead to advancements in the treatment and prevention of Alzheimer’s disease in humans....

Waterford researchers find link between Alzheimer’s disease and impaired vision arising from nutrient deficiency

14 Apr 2015 - A team from the Vision Research Centre at Waterford Institute of Technology has discovered that patients with Alzheimer’s disease have significantly worse vision than others in their age group and are more likely to be seriously deficient in carotenoids, key nutrients in the eye....

York U Alzheimer’s study on women at risk suggests functional decline relates to deteriorating brain wiring

02 Apr 2015 - In their latest brain imaging study on women at risk for Alzheimer’s disease, York University researchers have found deterioration in the pathways that serve to communicate signals between different brain regions needed for performing everyday activities such as driving a car or using a computer....

Severe Alzheimer's Patient Responds to Bryostatin Treatment

02 Apr 2015 - Researchers at the Blanchette Rockefeller Neurosciences Institute (BRNI) and the Marshall University Joan C. Edwards School of Medicine announced their findings from a new study entitled, "PSEN1 Variant in a Family with Atypical AD." An Alzheimer patient with very severe disease, genetically confirmed to have a known variant of PSEN1, showed promising benefits during treatment with the drug Bryostatin 1. Genetically confirmed Alzheimer’s patients as severely advanced as patient IV-18 have not shown this level of clinical improvement previously with other treatment(s). ...

Surprising finding provides more support for Alzheimer’s being an autoimmune disease

10 Mar 2015 - Brain levels of the lipid ceramide are high in Alzheimer’s disease, and now scientists have found increased levels of an antibody to the lipid in their disease model....

Decreases in Short-Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air Pollution

03 Feb 2015 - A new study by researchers at the Universities of Montana, Carleton, and North Carolina, and the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, heightens concerns over the detrimental impact of the apolipoprotein E (APOE) ε4 allele -- the most prevalent genetic risk for Alzheimer’s disease -- upon cognition, olfaction, and metabolic brain indices in healthy urban children and teens. These findings are published in the Journal of Alzheimer’s Disease....

New study postulates the role of dietary advanced glycation end products in the risk of Alzheimer's disease

03 Feb 2015 - New paper published in the Journal of Alzheimer's Disease provides evidence that cooking foods at high temperatures increases the risk of Alzheimer's disease. This study looked at the content of advanced glycation end products (AGEs) in national diets and clinical studies comparing and compared total AGEs to Alzheimer's disease rates....

Prostate cancer drug slows memory loss in women with Alzheimer’s disease

22 Jan 2015 - Women with Alzheimer’s disease showed stable cognition for a year when a drug that is more commonly used to treat advanced prostate cancer was added to their drug regimen, according to a new study from researchers at the University of Wisconsin-Madison....

First Evidence of Potential Efficacy of Tau Aggregation Inhibitor Therapy in Alzheimer’s Disease

20 Jan 2015 - The Journal of Alzheimer’s Disease has published today the results of the first clinical trial of a Tau Aggregation Inhibitor (TAI) in Alzheimer’s disease (AD).1 This Phase II clinical trial, conducted by TauRx Therapeutics Ltd (a Singapore incorporated spinout from the University of Aberdeen), provided the basis and rationale for subsequent Phase III clinical trials of a TAI in AD currently in progress. ...

A virtual reality brain training game can detect mild cognitive impairment (MCI), a condition that often predates Alzheimer’s disease (AD)

13 Jan 2015 - Greek researchers demonstrated the potential of a virtual supermarket cognitive training game as a screening tool for patients with mild cognitive impairment (MCI) among a sample of older adults. MCI is a condition that often predates Alzheimer’s disease (AD) and is characterized by memory loss and inability to execute complex activities such as financial planning. ...

Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer’s Dementia

09 Jan 2015 - A man-made form of insulin delivered by nasal spray may improve working memory and other mental capabilities in adults with mild cognitive impairment and Alzheimer’s disease dementia, according to a pilot study led by researchers at Wake Forest Baptist Medical Center....

Running and walking may lower Alzheimer’s Disease risk

16 Dec 2014 - An estimated 5 million Americans aged 65 and older have Alzheimer’s disease. As drug companies struggle to find a cure, new research from the National Runners’ and Walkers’ Health Study suggests that exercise earlier in life may substantially reduce Alzheimer’s disease mortality. The study, which appeared in an online prepublication from the Journal of Alzheimer’s Disease, involved over 154,000 runners and walkers who were followed for 11.6 years. There were 175 deaths where Alzheimer’s disease was diagnosed as an underlying or contributing cause of death during follow-up....

Better Detection, Prevention, and Pre-Clinical Treatment: Three Effective Tools in the Fight Against Alzheimer’s Disease

05 Dec 2014 - Detection, prevention, and preclinical treatment are three key areas that may make a difference in the battle to reduce the rapid rise of new Alzheimer’s disease (AD) cases every year. These three topics are the focus of an important new supplement to the Journal of Alzheimer’s Disease....

Mind before matter: do negative thoughts increase risk of Alzheimer’s disease?

19 Nov 2014 - Researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London have proposed that repetitive negative thinking (RNT), a common symptom of many psychological disorders, may increase the risk of developing Alzheimer’s disease....

New Research on Walnuts and the Fight Against Alzheimer’s Disease

22 Oct 2014 - A new animal study published in the Journal of Alzheimer’s Disease indicates that a diet including walnuts may have a beneficial effect in reducing the risk, delaying the onset, slowing the progression of, or preventing Alzheimer’s disease. ...

People at high risk of Alzheimer’s may have early visuomotor difficulties

08 Oct 2014 - Before there are any telltale behavioural signs of dementia, a simple test that combines thinking and movement could point to those with a heightened risk of developing Alzheimer’s disease and who are already having visuomotor difficulties, according to new research out of York University....

UB researchers corroborate the neuroprotective effects of Sirtuin 1 activation on mice with Alzheimer’s disease

07 Oct 2014 - A study coordinated by the University of Barcelona (UB) has described a mechanism that plays a key role in the evolution of Alzheimer’s disease. According to the paper published in the Journal of Alzheimer’s Disease, the activation of the protein Sirtuin 1 in a murine model with familial Alzheimer’s disease has neuroprotective effects. The study, based on the PhD thesis developed by the researcher David Porquet (UB), first describes Sirtuin 1 pathway in this murine model. Mercè Pallàs, from the Department of Pharmacology and Therapeutic Chemistry at the Faculty of Pharmacy of UB, coordinates the study. The Bellvitge Biomedical Research Institute (IDIBELL) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) also collaborate in the study. ...

Marijuana compound may offer treatment for Alzheimer’s disease, University of South Florida preclinical study indicates

30 Sep 2014 - Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease, a recent study from neuroscientists at the University of South Florida shows....

Conversion of mild cognitive impairment to dementia among subjects with diabetes

17 Sep 2014 - Findings by researchers at the School of Public Health of Tianjin Medical University suggest that in a survival analysis of the cohorts, Type 2 diabetes mellitus with mild cognitive impairment (T2DM-MCI) accelerated the median progression to dementia by 2.74 years. ...

Study Finds Air Pollution Harmful to Young Brains

17 Sep 2014 - Pollution in many cities threatens the brain development in children. Findings by University of Montana Professor Dr. Lilian Calderón-Garcidueñas, MA, MD, Ph.D., and her team of researchers reveal that children living in megacities are at increased risk for brain inflammation and neurodegenerative changes, including Alzheimer’s or Parkinson’s disease. ...

Diabetes Mellitus and Mild Cognitive Impairment: Higher Risk in Middle Age?

03 Sep 2014 - Essen, Germany, September 2, 2014 – In a large population-based study of randomly selected participants in Germany, researchers found that mild cognitive impairment (MCI) occurred twice more often in individuals diagnosed with diabetes mellitus type 2. Interestingly, this strong association was only observed in middle-aged participants (50-65 years), whereas in older participants (66-80 years) the association vanished. This study is published in the Journal of Alzheimer’s Disease....

Marijuana compound may offer treatment for Alzheimer’s disease

01 Sep 2014 - Tampa, FL -- Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease, a recent study from neuroscientists at the University of South Florida shows....

Computerized Cognition Test Provides Better Assessment than Observation

28 Aug 2014 - Research published in the Journal of Alzheimer’s Disease this week suggests healthy older adults are less capable of observing their own cognitive decline over an 18 month period than Cogstate’s computerized brief battery (CBB). The study, conducted by neuropsychologists, also indicated that close family members were unable to perceive decline in the cognitive behavior of their partner and trial participant in social settings. ...

Human Brain Deficits of PKCe: Targeted for Alzheimer’s Disease Therapeutic and Diagnostic Trials

20 Aug 2014 - Today, researchers at the Blanchette Rockefeller Neurosciences Institute (BRNI) announced findings from a new study entitled, “PKCe Deficits in Alzheimer’s Disease Brains and Skin Fibroblasts.” These new findings offer significant promise for a new therapeutic and diagnostic approach to Alzheimer's disease (AD) that has remained so refractory to effective and early drug treatment. This approach is now the major focus of ongoing clinical trials being conducted by at BRNI/Neurotrope, Inc. collaboration. In contrast to past strategies, this new therapeutic strategy now being clinically tested, not only removes the precursors to amyloid plaques and tangles, it also induces the growth of new synapses and prevents neuronal death. ...

Drexel University College of Medicine Research May Lead to Improved Alzheimer’s/ Vascular Dementia Diagnostic Guidelines

14 Aug 2014 - Alzheimer’s disease (AD) and vascular dementia (VaD) are the most common forms of dementia. Traditionally, these illnesses have been treated as separate clinical syndromes. But new research led by Drexel University College of Medicine suggests that AD and VaD have much more in common than diagnostic guidelines currently allow. The study is set for publication in the September edition of the Journal of Alzheimer’s Disease....

Decline in Daily Functioning Related to Decreased Brain Activity in Early Stages of Alzheimer’s Disease

12 Aug 2014 - Decline in daily functioning associated with Alzheimer’s disease is related to alterations in activity in certain regions of the brain, according to a study published in the August 2014 issue of the Journal of Alzheimer’s Disease. ...

Dementia Risk Quadrupled in People with Mild Cognitive Impairment

07 Aug 2014 - In a long-term, large-scale population-based study of individuals aged 55 years or older in the general population researchers found that those diagnosed with mild cognitive impairment (MCI) had a four-fold increased risk of developing dementia or Alzheimer’s disease (AD) compared to cognitively healthy individuals. Several risk factors including older age, positive APOE-ɛ4 status, low total cholesterol levels, and stroke, as well as specific MRI findings were associated with an increased risk of developing MCI. The results are published in a supplement to the Journal of Alzheimer’s Disease. ...

JAD Leads the Field in New Study of More Than 6 Decades of AD Literature

06 Aug 2014 - There have been several studies mapping out Alzheimer’s disease (AD) research using bibliometrics. One of these studies was instrumental in building the Top 100 Most Prolific AD Investigators and Top 100 Most Cited AD Investigators lists that you’ll find on the JAD website....

Study disproves link between lyme disease and alzheimer’s

18 Jul 2014 - New research from the University of Toronto Mississauga definitively puts to rest a theory that Lyme disease causes Alzheimer’s....

Symptoms of depression predict dementia

17 Jul 2014 - People who develop a combination of mild cognitive problems and depressive symptoms in old age are more likely to develop Alzheimer’s than are their age peers with mild cognitive disorders and no symptoms of depression. This was the conclusion of a study conducted at the University of Antwerp, in which scientists followed a large group of elderly people with mild cognitive impairment. The study is appearing in a leading publication, the Journal of Alzheimer’s Disease....

Cocoa Extract May Counter Specific Mechanisms of Alzheimer’s Disease

25 Jun 2014 - A specific preparation of cocoa-extract called Lavado may reduce damage to nerve pathways seen in Alzheimer’s disease patients’ brains long before they develop symptoms, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published June 20 in the Journal of Alzheimer’s Disease (JAD). ...

Bob Olsson, PhD, Wins 2014 Alzheimer Award

28 May 2014 - We are proud to announce that Bob Olsson, PhD, has been chosen as the recipient of the 2014 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on microglia markers and Alzheimer’s disease....

Compound Reverses Symptoms of Alzheimer’s Disease in Mice, SLU Research Shows

21 May 2014 - A molecular compound developed by Saint Louis University scientists restored learning, memory and appropriate behavior in a mouse model of Alzheimer’s disease, according to findings in the May issue of the Journal of Alzheimer’s Disease. The molecule also reduced inflammation in the part of the brain responsible for learning and memory....

Study: Testosterone therapy can damage brain health in Caucasian men

06 May 2014 - Ads touting testosterone replacement therapy are ubiquitous on radio and television. But medical research has determined that its success at enhancing libido may come at a price....

No Evidence of AD-Associated Changes in Adolescents Carrying Genetic Risk Factors

09 Apr 2014 - Two studies published in the Journal of Alzheimer’s Disease indicate that some of the pathologic changes associated with Alzheimer’s disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease. In the first study, no differences were found in hippocampal volume or asymmetry between cognitively normal adolescent carriers and non-carriers of the ApoE ɛ4 or ɛ2 allelles. The second study reports no differences in plasma concentrations of amyloid-β peptides among young adult ɛ4, ɛ3 or ɛ2 carriers....

New Therapeutic Target Discovered for Alzheimer’s Disease

19 Mar 2014 - A team of scientists from the University of California, San Diego School of Medicine, the Medical University of South Carolina and San Diego-based American Life Science Pharmaceuticals, Inc., report that cathepsin B gene knockout or its reduction by an enzyme inhibitor blocks creation of key neurotoxic pGlu-Aβ peptides linked to Alzheimer’s disease (AD). Moreover, the candidate inhibitor drug has been shown to be safe in humans....

SDSC/UC San Diego Researchers Hone in on Alzheimer’s Disease

21 Feb 2014 - Researchers studying peptides using the Gordon supercomputer at the San Diego Supercomputer Center (SDSC) at the University of California, San Diego (UCSD) have found new ways to elucidate the creation of the toxic oligomers associated with Alzheimer’s disease. ...

Neuropsychological assessment more efficient than MRI for tracking disease progression in memory clinic patients

19 Feb 2014 - Investigators at the University of Amsterdam, The Netherlands, have shown that progression of disease in memory clinic patients can be tracked efficiently with 45 minutes of neuropsychological testing. MRI measures of brain atrophy were shown to be less reliable to pick up changes in the same patients. ...

2014 Neuroscience Neurology Brochure

31 Jan 2014 - Download the 2014 Neuroscience Neurology Brochure here. ...

Study Reveals Buildup of Amyloid in Brain Blood Vessels Promotes Early Cognitive Impairment

02 Jan 2014 - A team of Stony Brook University researchers led by William Van Nostrand, PhD, Professor in the Department of Neurosurgery, has discovered in a model of Alzheimer’s disease that early accumulation of a small protein, known as amyloid β, in the blood vessels of the brain can drive early cognitive impairment. The findings, published in the current online edition of the Journal of Alzheimer’s Disease, suggest that targeting early buildup of amyloid in brain blood vessels could be a potential treatment strategy in early stage disease. ...

Lifestyle holds key to predicting women’s brain health

19 Dec 2013 - Australian researchers have identified lifestyle factors that impair women’s brain performance as early as age 45....

A research team finds a method to predict Alzheimer's disease within two years of screening

03 Dec 2013 - At the first signs of memory loss, most people start worrying and wonder, “What if I have Alzheimer's disease?” And yet, the disease is often diagnosed late in its development and sometimes up to ten years after the first pathological changes have affected the brain. A major goal in the treatment of Alzheimer's disease has been to provide earlier diagnosis so that patients can receive treatment as early as possible. A study by Sylvie Belleville, PhD, Director of Research at the Institut universitaire de gériatrie de Montréal, an institution affiliated with Université de Montréal, has shown a way to do just that. In their study, Sylvie Belleville and her team accurately predicted (at a rate of 90%) which of their research subjects with mild cognitive impairment would receive a clinical diagnosis of Alzheimer's disease within the following two years and which subjects would not develop this disease. The study was published in Volume 38, Issue 2 of the prestigious Journal of Alzheimer's Disease. ...

Prescription of anti-Alzheimer medications to persons with mild cognitive impairment (MCI) is low in France

15 Nov 2013 - In France prescription of drugs for Alzheimer’s disease (AD) is strictly regulated. The Department of Public Health and the Memory Clinic of Nice University Hospital have explored real world prescriptions of anti-AD medications in patients with mild cognitive impairment (MCI) not AD. A national survey [1] was set up from the data of the French National Alzheimer Databank (BNA) and shows that off label prescriptions are not frequent and concern 6.1% of MCI patients (versus a quarter of MCI patients in the US [2]). French physicians seem to limit this kind of prescription to MCI patients at risk of conversion to AD: more aged, with a more important quantitative cognitive impairment and with a memory predominant form. In a context of low efficacy of the available medications against AD this study emphasizes the need to develop more preventive drugs....

New Method Predicts Time from Alzheimer’s Onset to Nursing Home, Death

08 Nov 2013 - A Columbia University Medical Center-led research team has clinically validated a new method for predicting time to full-time care, nursing home residence, or death for patients with Alzheimer’s disease. The method, which uses data gathered from a single patient visit, is based on a complex model of Alzheimer’s disease progression that the researchers developed by consecutively following two sets of Alzheimer’s patients for 10 years each. The results were published online ahead of print in the Journal of Alzheimer's Disease....

Sanders-Brown Researchers Produce New Research on Little-Understood Brain Disease

08 Nov 2013 - As the population of older adults continues to grow, researchers at the University of Kentucky Sanders-Brown Center on Aging are engaged in work to understand the mechanisms of a variety of diseases that predominately affect those of advanced age....

A Potential New Strategy to Face Dementia

08 Oct 2013 - Alzheimer’s disease (AD) affects millions of people worldwide. As a result of an increase in life expectancy, the number of patients with dementia is expected to increase dramatically. Due to the lack of effective treatments that can slow down or reverse the progression of AD, preventive measures to lower the prevalence rate of AD by means of managing potential or actual risk factors is a reasonable clinical strategy. In this respect, identifying treatable factors which are able to promote cognitive deterioration would have important practical implications....

Novel accelerometer-based algorithm detects early signals of Alzheimer’s disease in everyday motion behavior

08 Oct 2013 - The projected substantial increase in Alzheimer’s disease due to the higher life expectancy in modern societies is one of the great future challenges of health care systems worldwide. Alzheimer’s disease leads to significant changes in the temporal structure of activities that impair everyday activities. Abnormal motion behavior and degeneration of the sleep-waking cycle are among the most severe behavioral symptoms. An early detection and even a prediction of these behaviors would allow a timely onset of interventions that aim to delay the manifestation or exacerbation of symptoms and reduce the need of institutionalized care....

Changing to the Western diet increases risk of Alzheimer's disease

25 Sep 2013 - In a paper just published electronically in the Journal of Alzheimer’s Disease, dramatic increases in Alzheimer’s disease (AD) in Japan and significant increases in developing countries are linked to changes in national diets....

UCLA study suggests iron is at core of Alzheimer's disease

26 Aug 2013 - Alzheimer's disease has proven to be a difficult enemy to defeat. After all, aging is the No. 1 risk factor for the disorder, and there's no stopping that. ...

Breastfeeding may reduce Alzheimer’s risk

08 Aug 2013 - Mothers who breastfeed their children may have a lower risk of developing Alzheimer’s Disease, with longer periods of breastfeeding also lowering the overall risk, a new study suggests....

Exercise May be the Best Medicine for Alzheimer’s Disease, UMD Study Shows

07 Aug 2013 - New research out of the University of Maryland School of Public Health shows that exercise may improve cognitive function in those at risk for Alzheimer’s by improving the efficiency of brain activity associated with memory. Memory loss leading to Alzheimer’s disease is one of the greatest fears among older Americans. While some memory loss is normal and to be expected as we age, a diagnosis of mild cognitive impairment, or MCI, signals more substantial memory loss and a greater risk for Alzheimer’s, for which there currently is no cure. ...

Poor dental health may lead to Alzheimer’s, study suggests

01 Aug 2013 -

People with poor oral hygiene or gum disease may be at a greater risk of developing Alzheimer’s disease, a new study led by The University of Central Lancashire (UCLan) School of Medicine and Dentistry suggests.

The research, which has received international collaboration, and led by Professor Stjohn Crean and Dr Sim Singhrao from UCLan, examined brain samples donated by ten patients without dementia and ten patients suffering from dementia. The research demonstrated the presence of products from Porphyromonas gingivalis in brains from patients suffering from dementia.

This bacterium is commonly associated with chronic periodontal (gum) disease. These bacteria enter the bloodstream through daily activities such as eating, chewing, tooth brushing but especially following invasive dental treatment, and from there, potentially enter the brain on a regular basis. The researchers propose that every time they reach the brain, the bacteria may trigger immune system responses by already primed brains cells, causing them to release more chemicals that kill neurons. This could be one mechanism that leads to changes in the brain, which is typical of Alzheimer’s disease, and could be responsible for causing symptoms such as confusion and deteriorating memory.

The research benefited from donated brain samples, provided by Brains for Dementia Research, a brain donation scheme supported by Alzheimer’s Research UK and Alzheimer’s Society. Finding P. gingivalis in the brains from dementia sufferers compared to those without dementia is significant as its presence in Alzheimer’s diseased brains has not been documented previously and at the same time adds to a growing body of evidence that suggests an association between poor oral health and dementia.

These published research findings from human brain specimens are further supported by recent (as yet unpublished) research from the same group, on periodontal disease, using animal models, which has been carried out in collaboration with the University of Florida. This animal work has confirmed that P. gingivalis in the mouth finds its way to the brain once the periodontal disease becomes established.

Professor Stjohn Crean, Dean, School of Medicine & Dentistry said:

“Whereas previous studies have indicated a link between dementia and other bacteria and viruses such as the Herpes simplex virus type I, this new research indicates a possible association between gum disease and individuals who may be susceptible to developing Alzheimer’s disease, if exposed to the appropriate trigger! Research currently underway at UCLan is playing an active role in exploring this link, but it remains to be proven whether poor dental hygiene can lead to dementia in healthy people, which obviously could have significant implications for the population as a whole.  It is also likely that these bacteria could make the existing disease condition worse.”

Dr. Sim K. Singhrao, Senior Research Fellow at UCLan said: “We are working on the theory that when the brain is repeatedly exposed to bacteria and/or their debris from our gums, subsequent immune responses may lead to nerve cell death and possibly memory loss. Thus, continued visits to dental hygiene professionals throughout one’s life may be more important than currently envisaged with inferences for health outside of the mouth only. To help us prove our hypothesis we are hoping to use the Brains for Dementia Research tissue resource to examine brain tissue from people with both intact and compromised memory who have relevant dental records. The future of the research aims to discover if P. gingivalis can be used as a marker, via a simple blood test, to predict the development of Alzhiemer’s disease in at risk patients.” 

Notes to editors:

The University of Central Lancashire (UCLan), with Professor Lakshmyya Kesavalu who specialises in animal models of periodontal disease (Department of Periodontology and Oral Biology, College of Dentistry, University of Florida, USA).

The University of Central Lancashire (UCLan) has developed an enviable reputation as an institution that innovates, evolving its course portfolio to over 500 undergraduate programmes and 180 postgraduate courses. The University has an established research reputation within the areas of Business, Health, Humanities and Science. In the recent Research Assessment Exercise, all 17 subject areas submitted were rated as containing research of international excellence while 11 areas were assessed to be undertaking research which is world-leading. With approximately 32,000 students, the University indirectly contributes close to £250 million into the regional economy every year. UCLan is currently in the process of spending more than £120 million on new buildings and facilities to support teaching, learning and leisure activities.

Brains for Dementia Research is a partnership between the Alzheimer’s Research UK and Alzheimer’s Society to promote brain donation and develop a network of brain tissue banks in England and Wales for dementia research. The project is being run in association with the Medical Research Council. The Brains for Dementia Research coordinating centre is based at King’s College London and there are six assessment and donation centres based at the Universities of Cardiff, London, Manchester, Newcastle, Oxford and Bristol. 

For more information contact:

Natasha Gandhi
PR Officer - University of Central Lancashire
T:  0207 067 0295   
E:  ngandhi@webershandwick.com

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue. Sophie Poole, Sim K. Singhrao, Lakshmyya Kesavalu, Michael A. Curtis, St John Crean. Journal of Alzheimer's Disease, DOI 10.3233/JAD-121918. Published by IOS Press.

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Ineke van Rossum, MD, Receives 2013 Alzheimer Award

01 Jul 2013 - Ineke van Rossum, MD, has been chosen as the recipient of the 2013 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of her outstanding work that implicates a different role for biomarkers in the diagnosis and prognosis of subjects with mild cognitive impairment due to Alzheimer’s disease....

New Alzheimer’s research suggests possible cause: the interaction of proteins in the brain

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Alzheimer's Leaves Clues in Blood

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UC Santa Barbara Scientists Discover Cinnamon Compounds’ Potential Ability to Prevent Alzheimer’s

29 May 2013 - Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important health benefit? The common baking spice might hold the key to delaying the onset of — or warding off — the effects of Alzheimer’s disease....

UCLA brain-imaging tool and stroke risk test help identify cognitive decline early

04 Apr 2013 - UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia. ...

Probable amnestic MCI people are in the highest risk of conversion to dementia

05 Mar 2013 - People with probable amnestic mild cognitive impairment (MCI) have the most and closest risk of conversion to dementia, mainly Alzheimer’s disease (AD), according to a recent research of Fundació ACE, Barcelona Alzheimer Treatment and Research Center (www.fundacioace.com). That is, amnestic MCI subjects without any comorbidity that could explain their cognitive deficits have 8.5 times more risk to convert to dementia than people with non-amnestic MCI caused by cerebrovascular pathology or psycho-affective symptoms. Furthermore, a storage pattern of memory impairment, the multiple domain condition, and the presence of at least one ε4 allele increase the risk of conversion to dementia in MCI subjects. ...

Most U.S. neurologists plan to use new brain scan for Alzheimer’s detection

14 Feb 2013 - A large majority of the nation's top neurologists say they would use a recently approved amyloid detection brain scan to evaluate their patients for Alzheimer's disease if the scan was paid for by health insurance, according to a survey recently published in the Journal of Alzheimer's Disease....

Vitamin D, omega-3 may help clear amyloid plaques found in Alzheimer's

07 Feb 2013 - A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system's ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer's disease. ...

Exercise can slow onset of Alzheimer’s memory loss — scientists identify link

28 Jan 2013 - Keeping active can slow down the progression of memory loss in people with Alzheimer’s disease, a study has shown. A team of researchers from The University of Nottingham has identified a stress hormone produced during moderate exercise that may protect the brain from memory changes related to the disease. The work, funded by Research into Ageing (Age UK) and the University and published in the Journal of Alzheimer’s Disease, may also explain why people who are susceptible to stress are at more risk of developing the disease. ...

Method developed by VTT targets diagnosis of early Alzheimer’s disease

05 Dec 2012 - A software tool called PredictAD developed by VTT Technical Research Centre of Finland promises to enable earlier diagnosis of the disease on the basis of patient measurements and large databases. Alzheimer’s disease currently takes on average 20 months to diagnose in Europe. VTT has shown that the new method could allow as many as half of patients to get a diagnosis approximately a year earlier....

2013 Neuroscience Neurology Brochure

27 Nov 2012 - Download the 2013 Neuroscience Neurology Brochure here. ...

Controlling Vascular Disease May Be Key to Reducing Prevalence of Alzheimer’s Disease

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New Diagnostic Biomarkers Offer Ray of Hope for Alzheimer’s Disease

30 Aug 2012 - Alzheimer’s disease (AD) is one of the most common brain disorders, with an estimated 35 million people affected worldwide. In the last decade, research has advanced our understanding of how AD affects the brain. However, diagnosis continues to rely primarily on neuropsychological tests which can only detect the disease after clinical symptoms begin. In a supplement to the Journal of Alzheimer’s Disease, investigators report on the development of imaging-based biomarkers that will have an impact on diagnosis before the disease process is set in motion. ...

Tai Chi Increases Brain Size and Benefits Cognition in Randomized Controlled Trial of Chinese Elderly

20 Jun 2012 - Scientists from the University of South Florida and Fudan University in Shanghai found increases in brain volume and improvements on tests of memory and thinking in Chinese seniors who practiced Tai Chi three times a week, reports an article published today in the Journal of Alzheimer’s Disease. ...

Link between Metabolic Disorders and Alzheimer’s Disease Examined

15 Jun 2012 - No effective treatments are currently available for the prevention or cure of Alzheimer’s disease (AD), the most frequent form of dementia in the elderly. The most recognized risk factors, advancing age and having the apolipoprotein E Ɛ4 gene, cannot be modified or treated. Increasingly, scientists are looking toward other risk factors to identify preventive and therapeutic strategies. Much attention recently has focused on the metabolic syndrome (MetS), with a strong and growing body of research suggesting that metabolic disorders and obesity may play a role in the development of dementia. ...

Drink coffee to avoid Alzheimer's Disease: study shows older adults benefit

06 Jun 2012 - Research shows drinking coffee can avoid the onset of Alzheimer's Disease in people over 65 years old. ...

Scientists Reveal Early Diagnostic Clues for Alzheimer’s Disease Using Advanced Brain Imaging Technology

03 May 2012 -

Alzheimer's disease (AD) is a major neurodegenerative disorder that affects millions of people worldwide. New and accurate techniques for early diagnosis are critical. Pravat K. Mandal, PhD, and his colleagues have developed a completely non-invasive brain imaging technique to measure specific brain chemical changes. This provides a signature of the early stages of AD from the hippocampal region of the brain. Their work is reported in the Journal of Alzheimer’s Disease.
    
“Alzheimer’s disease has become a silent tsunami in the aging population,” says Dr. Mandal, who is associated with the National Brain Research Center, Gurgaon, India, and Johns Hopkins University School of Medicine.  “This discovery of a diagnostic technique that requires no blood work or radiation, and that can be conducted in less than fifteen minutes, may offer hope to Alzheimer’s disease patients and their families.”

Dr. Mandal and his co-investigators studied the brains of normal controls, AD patients, and patients with mild cognitive impairment (MCI) using multi-voxel 31P magnetic resonance spectroscopy (MRS) imaging, along with an advanced analytical tool, to assess brain chemistry in the hippocampal regions.  They observed during the course of their study that the left hippocampus becomes alkaline in AD patients, which is in contrast to the normal aging process in which the brain tends to be more acidic.  

Dr. Mandal and his colleagues also identified four brain chemicals that change significantly in pre-Alzheimer and Alzheimer disease patients compared to normal subjects.  They are phosphomonoester (PME), the building block of neuronal membrane; phosphodiester (PDE), the membrane degradation product; phosphocreatine (PCr), stored energy for brain functioning; and adenosine triphosphate (-ATP), the source of brain energy.  The level of PME is significantly decreased in the left hippocampal areas of these patients, and the levels of PDE, PCr, and -ATP are increased.  

“In the left hippocampus the increase in pH to the alkaline range, along with statistically significant increases in PDE, PCr, and y-ATP and decreases in PDE, serve as a promising new biomarker for AD,” notes Dr. Mandal.  He and his colleagues plan to conduct longitudinal studies with Alzheimer and Parkinson patients with larger sample sizes to investigate specificity of their test.  “It is our hope that such clinical research, using state-of-the-art technology, may give new hope to cognitively impaired patients for an earlier and more predictable AD diagnosis.”   

These clinical studies were performed in collaboration with Dr. Manjari Tripathi, MD, DM, Department of Neurology, All India Institute of Medical Sciences, New Delhi. This study was made possible through the research funding, to Dr. Mandal, from the Department of Biotechnology, Government of India.

#  #  #

Mapping of Hippocampal pH and Neurochemicals from in vivo Multi-Voxel 31P Study in Healthy Normal Young Male/Female, Mild Cognitive Impairment, and Alzheimer’s Disease,” by Pravat K. Mandal, Himanshu Akolkar and  Manjari Tripathi. Journal of Alzheimer’s Disease, Volume 31 (2012), Supplement 3, DOI 10.3233/JAD-2012-120166.

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Anders Lönneborg, PhD, Receives 2012 Alzheimer Award

02 May 2012 -

Anders Lönneborg, PhD, has been chosen as the recipient of the 2012 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on the detection of early Alzheimer’s disease.

“My co-authors and I are extremely pleased to have been chosen by a distinguished group of peers as the recipients of this year’s Journal of Alzheimer’s Disease award for our work on the development of ADtect®, the 96-gene expression test for detection of early Alzheimer’s disease,” said Dr. Lönneborg, Research Director, DiaGenic, Oslo, Norway.

Each year the more than 500 Associate Editors of the Journal of Alzheimer’s Disease vote to select an outstanding article published the previous year to receive this prestigious award, which is made possible by support from IOS Press and Elan Pharmaceuticals. Dr. Lönneborg will be presented with the bronze Alzheimer Medal featuring the likeness of Alois Alzheimer. The winning paper is entitled, “A Novel Blood Test for the Early Detection of Alzheimer’s Disease" (J Alzheimers Dis 23, 121-129, 2011), by A. Lönneborg et al.

The team behind the paper, led by Dr. Lönneborg, investigated the diagnostic value of a 96-gene expression array for detection of early AD. A disease classification algorithm was developed and was validated in two steps using an independent initial test set and another second test set. A similar accuracy (72%), sensitivity (72%) and specificity (71%) were achieved both in the initial analysis and in the two independent test sets. When compared with available CSF biomarker data high agreement (80%) was found.

“Although further studies are needed to confirm these findings, they suggest that the gene expression test using a convenient blood sample can aid the diagnosis of mild to moderate AD,” adds Dr. Lönneborg.

Anders Lönneborg, PhD, received his degree in molecular plant physiology from the University of Umeå, Sweden in 1986. After a postdoctoral fellowship in molecular plant biology at Michigan State University under the mentorship of Prof. Chris Somerville, and working as Research Scientist at the Norwegian University of Life Sciences and as Senior Scientist at the Norwegian Forest Research Institute, Dr. Lönneborg was acknowledged competence as professor in 1995. In 1998 he founded DiaGenic with Dr. Praveen Sharma, where he has served as Research Director since the company’s inception and CEO from 2003-2007.

DiaGenic’s focus has always been to develop blood-based tests based on gene expression to aid the diagnosis of important diseases, primarily neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease. The company aims to develop companion diagnostics and biomarkers to aid the development of novel treatments for Alzheimer’s disease.

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