Journal of Alzheimer’s Disease

impact factor 2012 4.174
ISSN print
ISSN online
38-42; 20 issues
Last issue (40:2) online on 31 March 2014
Next issue
40:3 scheduled for April 2014
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Institutional subscription for 2014 €1900 / US$2520 Excluding VAT
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JAD Introduces New Section: Ethics Review
The Journal of Alzheimer’s Disease has launched a new feature, “Ethics Review,” which will provide support and guidance to move ethical decision-making forward. The goal is to create a forum for dementia researchers, clinicians[removed comma] and policy makers to bring greater clarity and constructive discussion to define risks and benefits from the perspectives of diverse disciplines. The first contribution, "Ethics Review as a Catalyst for Progress" by Allyson C. Rosen, John Wesson Ashford and George Perry is freely available online

New Sister Journal: Journal of Neuromuscular Diseases
JAD welcomes a new sister journal: Journal of Neuromuscular Diseases (JND), edited by Carsten G. Bönnemann and Hanns Lochmüller. This journal is now accepting papers. The first 2 volumes will be freely available.

The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer’s disease.

In Remembrance of Editor-in-Chief Mark A. Smith

Click here to read JAD's article on the top 100 researchers in Alzheimer's Disease, free of charge.

George Perry, PhD
College of Sciences
University of Texas at San Antonio
One UTSA Circle
San Antonio, Texas 78249, USA
Tel: +1.210.458.4450

Managing Editor
Beth Kumar
Department of Pathology
Case Western Reserve University
2103 Cornell Road
Cleveland, Ohio 44106, USA
Email: editorial@j-alz.com

Deputy Editor
Jesus Avila

Deputy Editor
Xiongwei Zhu

Deputy Editor
Massimo Tabaton

Scientometrics Editor
Aaron A. Sorensen

Former Editor-in-Chief, 2001-2010
Mark A. Smith, PhD

Senior Editors
Alejandra Alonso
Gary Arendash
J. Wesson Ashford
Claudio Babiloni
Barbara Borroni
Jack C. de la Torre
Daniela Galimberti
Amos Korczyn
Debomoy Lahiri
Piotr Lewczuk
Patrizia Mecocci
Miguel Medina
Thomas Shea
Henrik Zetterberg

Associate Editors
Please find the full list of the Associate Editors at http://j-alz.com/board.

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No Evidence of AD-Associated Changes in Adolescents Carrying Genetic Risk Factors

09 Apr 2014 - Two studies published in the Journal of Alzheimer’s Disease indicate that some of the pathologic changes associated with Alzheimer’s disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease. In the first study, no differences were found in hippocampal volume or asymmetry between cognitively normal adolescen...

New Therapeutic Target Discovered for Alzheimer’s Disease

19 Mar 2014 - A team of scientists from the University of California, San Diego School of Medicine, the Medical University of South Carolina and San Diego-based American Life Science Pharmaceuticals, Inc., report that cathepsin B gene knockout or its reduction by an enzyme inhibitor blocks creation of key neurotoxic pGlu-Aβ peptides linked to Alzheimer’s disease (AD). Moreover, the candidate inhibitor drug h...

SDSC/UC San Diego Researchers Hone in on Alzheimer’s Disease

21 Feb 2014 - Researchers studying peptides using the Gordon supercomputer at the San Diego Supercomputer Center (SDSC) at the University of California, San Diego (UCSD) have found new ways to elucidate the creation of the toxic oligomers associated with Alzheimer’s disease. ...

Neuropsychological assessment more efficient than MRI for tracking disease progression in memory clinic patients

19 Feb 2014 - Investigators at the University of Amsterdam, The Netherlands, have shown that progression of disease in memory clinic patients can be tracked efficiently with 45 minutes of neuropsychological testing. MRI measures of brain atrophy were shown to be less reliable to pick up changes in the same patients. ...

2014 Neuroscience Neurology Brochure

31 Jan 2014 - Download the 2014 Neuroscience Neurology Brochure here. ...

Study Reveals Buildup of Amyloid in Brain Blood Vessels Promotes Early Cognitive Impairment

02 Jan 2014 - A team of Stony Brook University researchers led by William Van Nostrand, PhD, Professor in the Department of Neurosurgery, has discovered in a model of Alzheimer’s disease that early accumulation of a small protein, known as amyloid β, in the blood vessels of the brain can drive early cognitive impairment. The findings, published in the current online edition of the Journal of Alzheimer’s Di...

Lifestyle holds key to predicting women’s brain health

19 Dec 2013 - Australian researchers have identified lifestyle factors that impair women’s brain performance as early as age 45....

UA Study Shows Intensive Exercise Training Program Designed for Dementia Patients Improves Care in Clinical Setting

19 Dec 2013 - A study by researchers at the University of Arizona Department of Surgery published in the Journal of Alzheimer's Disease showed an innovative, customized exercise program applied to clinical practice substantially improved care for dementia patients....

A research team finds a method to predict Alzheimer's disease within two years of screening

03 Dec 2013 - At the first signs of memory loss, most people start worrying and wonder, “What if I have Alzheimer's disease?” And yet, the disease is often diagnosed late in its development and sometimes up to ten years after the first pathological changes have affected the brain. A major goal in the treatment of Alzheimer's disease has been to provide earlier diagnosis so that patients can receive treatmen...

Prescription of anti-Alzheimer medications to persons with mild cognitive impairment (MCI) is low in France

15 Nov 2013 - In France prescription of drugs for Alzheimer’s disease (AD) is strictly regulated. The Department of Public Health and the Memory Clinic of Nice University Hospital have explored real world prescriptions of anti-AD medications in patients with mild cognitive impairment (MCI) not AD. A national survey [1] was set up from the data of the French National Alzheimer Databank (BNA) and shows that off...

New Method Predicts Time from Alzheimer’s Onset to Nursing Home, Death

08 Nov 2013 - A Columbia University Medical Center-led research team has clinically validated a new method for predicting time to full-time care, nursing home residence, or death for patients with Alzheimer’s disease. The method, which uses data gathered from a single patient visit, is based on a complex model of Alzheimer’s disease progression that the researchers developed by consecutively following two s...

Sanders-Brown Researchers Produce New Research on Little-Understood Brain Disease

08 Nov 2013 - As the population of older adults continues to grow, researchers at the University of Kentucky Sanders-Brown Center on Aging are engaged in work to understand the mechanisms of a variety of diseases that predominately affect those of advanced age....

A Potential New Strategy to Face Dementia

08 Oct 2013 - Alzheimer’s disease (AD) affects millions of people worldwide. As a result of an increase in life expectancy, the number of patients with dementia is expected to increase dramatically. Due to the lack of effective treatments that can slow down or reverse the progression of AD, preventive measures to lower the prevalence rate of AD by means of managing potential or actual risk factors is a reaso...

Novel accelerometer-based algorithm detects early signals of Alzheimer’s disease in everyday motion behavior

08 Oct 2013 - The projected substantial increase in Alzheimer’s disease due to the higher life expectancy in modern societies is one of the great future challenges of health care systems worldwide. Alzheimer’s disease leads to significant changes in the temporal structure of activities that impair everyday activities. Abnormal motion behavior and degeneration of the sleep-waking cycle are among the most sev...

Changing to the Western diet increases risk of Alzheimer's disease

25 Sep 2013 - In a paper just published electronically in the Journal of Alzheimer’s Disease, dramatic increases in Alzheimer’s disease (AD) in Japan and significant increases in developing countries are linked to changes in national diets....

UCLA study suggests iron is at core of Alzheimer's disease

26 Aug 2013 - Alzheimer's disease has proven to be a difficult enemy to defeat. After all, aging is the No. 1 risk factor for the disorder, and there's no stopping that. ...

Breastfeeding may reduce Alzheimer’s risk

08 Aug 2013 - Mothers who breastfeed their children may have a lower risk of developing Alzheimer’s Disease, with longer periods of breastfeeding also lowering the overall risk, a new study suggests....

Exercise May be the Best Medicine for Alzheimer’s Disease, UMD Study Shows

07 Aug 2013 - New research out of the University of Maryland School of Public Health shows that exercise may improve cognitive function in those at risk for Alzheimer’s by improving the efficiency of brain activity associated with memory. Memory loss leading to Alzheimer’s disease is one of the greatest fears among older Americans. While some memory loss is normal and to be expected as we age, a diagnosis o...

Poor dental health may lead to Alzheimer’s, study suggests

01 Aug 2013 -

People with poor oral hygiene or gum disease may be at a greater risk of developing Alzheimer’s disease, a new study led by The University of Central Lancashire (UCLan) School of Medicine and Dentistry suggests.

The re...

Ineke van Rossum, MD, Receives 2013 Alzheimer Award

01 Jul 2013 - Ineke van Rossum, MD, has been chosen as the recipient of the 2013 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of her outstanding work that implicates a different role for biomarkers in the diagnosis and prognosis of subjects with mild cognitive impairment due to Alzheimer’s disease....

New Alzheimer’s research suggests possible cause: the interaction of proteins in the brain

26 Jun 2013 - For years, Alzheimer's researchers have focused on two proteins that accumulate in the brains of people with Alzheimer's and may contribute to the disease: plaques made up of the protein amyloid-beta, and tangles of another protein, called tau....

Alzheimer's Leaves Clues in Blood

05 Jun 2013 - Alzheimer researchers in Spain have taken a step closer to finding a blood test to help in the diagnosis of Alzheimer’s disease. ...

UC Santa Barbara Scientists Discover Cinnamon Compounds’ Potential Ability to Prevent Alzheimer’s

29 May 2013 - Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important health benefit? The common baking spice might hold the key to delaying the onset of — or warding off — the effects of Alzheimer’s disease....

UCLA brain-imaging tool and stroke risk test help identify cognitive decline early

04 Apr 2013 - UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia. ...

Probable amnestic MCI people are in the highest risk of conversion to dementia

05 Mar 2013 - People with probable amnestic mild cognitive impairment (MCI) have the most and closest risk of conversion to dementia, mainly Alzheimer’s disease (AD), according to a recent research of Fundació ACE, Barcelona Alzheimer Treatment and Research Center (www.fundacioace.com). That is, amnestic MCI subjects without any comorbidity that could explain their cognitive deficits have 8.5 times more risk...

Most U.S. neurologists plan to use new brain scan for Alzheimer’s detection

14 Feb 2013 - A large majority of the nation's top neurologists say they would use a recently approved amyloid detection brain scan to evaluate their patients for Alzheimer's disease if the scan was paid for by health insurance, according to a survey recently published in the Journal of Alzheimer's Disease....

Vitamin D, omega-3 may help clear amyloid plaques found in Alzheimer's

07 Feb 2013 - A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system's ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer's disease. ...

Exercise can slow onset of Alzheimer’s memory loss — scientists identify link

28 Jan 2013 - Keeping active can slow down the progression of memory loss in people with Alzheimer’s disease, a study has shown. A team of researchers from The University of Nottingham has identified a stress hormone produced during moderate exercise that may protect the brain from memory changes related to the disease. The work, funded by Research into Ageing (Age UK) and the University and published in the ...

Method developed by VTT targets diagnosis of early Alzheimer’s disease

05 Dec 2012 - A software tool called PredictAD developed by VTT Technical Research Centre of Finland promises to enable earlier diagnosis of the disease on the basis of patient measurements and large databases. Alzheimer’s disease currently takes on average 20 months to diagnose in Europe. VTT has shown that the new method could allow as many as half of patients to get a diagnosis approximately a year earlier...

2013 Neuroscience Neurology Brochure

27 Nov 2012 - Download the 2013 Neuroscience Neurology Brochure here. ...

Controlling Vascular Disease May Be Key to Reducing Prevalence of Alzheimer’s Disease

06 Nov 2012 - Over the last 15 years, researchers have found a significant association between vascular diseases such as hypertension, atherosclerosis, diabetes type 2, hyperlipidemia, and heart disease and an increased risk of Alzheimer’s disease. In a special issue of the Journal of Alzheimer’s Disease, leading experts provide a comprehensive overview of the pathological, biochemical, and physiological p...

New Diagnostic Biomarkers Offer Ray of Hope for Alzheimer’s Disease

30 Aug 2012 - Alzheimer’s disease (AD) is one of the most common brain disorders, with an estimated 35 million people affected worldwide. In the last decade, research has advanced our understanding of how AD affects the brain. However, diagnosis continues to rely primarily on neuropsychological tests which can only detect the disease after clinical symptoms begin. In a supplement to the Journal of Alzheime...

Tai Chi Increases Brain Size and Benefits Cognition in Randomized Controlled Trial of Chinese Elderly

20 Jun 2012 - Scientists from the University of South Florida and Fudan University in Shanghai found increases in brain volume and improvements on tests of memory and thinking in Chinese seniors who practiced Tai Chi three times a week, reports an article published today in the Journal of Alzheimer’s Disease. ...

Link between Metabolic Disorders and Alzheimer’s Disease Examined

15 Jun 2012 - No effective treatments are currently available for the prevention or cure of Alzheimer’s disease (AD), the most frequent form of dementia in the elderly. The most recognized risk factors, advancing age and having the apolipoprotein E Ɛ4 gene, cannot be modified or treated. Increasingly, scientists are looking toward other risk factors to identify preventive and therapeutic strategies. Much ...

Drink coffee to avoid Alzheimer's Disease: study shows older adults benefit

06 Jun 2012 - Research shows drinking coffee can avoid the onset of Alzheimer's Disease in people over 65 years old. ...

Scientists Reveal Early Diagnostic Clues for Alzheimer’s Disease Using Advanced Brain Imaging Technology

03 May 2012 -

Alzheimer's disease (AD) is a major neurodegenerative disorder that affects millions of people worldwide. New and accurate techniques for early diagnosis are critical. Pravat K. Mandal, PhD, and his colleagues have developed a completely non-invasive brain imaging technique to measure specific brain chemical changes. This provides a signature of the early stages of AD from the hippocampal regio...

Anders Lönneborg, PhD, Receives 2012 Alzheimer Award

02 May 2012 -

Anders Lönneborg, PhD, has been chosen as the recipient of the 2012 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on the detection of early Alzheimer’s disease.

“My co-authors and I are extremely pleased to have been chosen ...

WesternU Dean to publish Alzheimer’s research

18 Apr 2012 - Michel Baudry, PhD, dean of the Graduate College of Biomedical Sciences at Western University of Health Sciences, will publish his research on the critical role of oxidative stress in Alzheimer’s disease and a potential treatment....

Antioxidant May Disrupt Alzheimer's Disease Process

10 Apr 2012 - Alzheimer’s disease (AD) is now the sixth leading cause of death among Americans, affecting nearly 1 in 8 people over the age of 65. There is currently no treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals like copper and zinc may start years before the onset of AD symptoms. A new stu...

Pulse Pressure Elevation Could Presage Cerebrovascular Disease in Alzheimer’s Patients

10 Apr 2012 - Researchers at the University of California, San Diego and Veterans Affairs San Diego Healthcare System have shown that elevated pulse pressure may increase the risk of cerebrovascular disease (CVD) in older adults with Alzheimer’s disease (AD). Their study has been published in the early online edition of Journal of Alzheimer's Disease in advance of the June 5 print publication....

Amyloid beta in the brain of individuals with Alzheimer’s disease

02 Apr 2012 - The deposition of amyloid beta in the brain of individuals with Alzheimer’s disease is the focus of much research into both its cause and treatment. ...

MRI and neuropsychological tests best predict Alzheimer’s disease in old patients

02 Apr 2012 - Investigators from the University of Amsterdam, Netherlands, have shown that in most elderly patients invasive and expensive techniques, i.e. lumbar puncture and PET scan, are not useful to establish the diagnosis of Alzheimer’s disease. They arrived at this conclusion after analysis of data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a large collaborative research project of ...

Brain atrophy can predict further cognitive decline in Alzheimer’s disease

27 Mar 2012 - Researchers from the Alzheimer Center, VU University Medical Center in Amsterdam, the Netherlands, have found a way to predict clinical progression of Alzheimer’s disease in subjects in the predementia stage. Patients with mild memory problems, who had brain atrophy on MRI scan or a high level of tau protein in cerebrospinal fluid showed more rapid cognitive decline than subjects without this sh...

Role of Amyloid Beta as Sensors and Protectors in Alzheimer’s and Other Diseases Explored

27 Mar 2012 - Alzheimer’s disease is the sixth leading cause of death in the United States and the only cause of death among the top 10 in America without a way to prevent, cure or even slow its progression, according to the Alzheimer’s Association. Today, 5.4 million Americans are living with the disease, and another American develops it every 69 seconds....

Variability in blood-based amyloid-β assays: The need for consensus on pre-analytical processing

26 Mar 2012 - Associate Professor Kevin Barnham from the Mental Health Research Institute has recently finished a report that highlights both the need for standard blood collection and processing methods in Alzheimer’s disease research, and a way forward. ...

Ein neuer Test könnte die Diagnose und Entwicklung von Medikamenten für die Alzheimer-Krankheit erleichtern

26 Mar 2012 - Ein internationales Team von Forschern hat eine neue Methode zur Messung des im Gehirn abgelagerten Beta-Amyloid entwickelt. Dieser Protein-Komplex steht im Verdacht, größere Schädigungen von Nervenzellen sowie Dysfunktionen bei der Alzheimer-Krankheit zu verursachen. Die neue Methode könnte die Erkennung der Erkrankung sowie Entwicklung von Medikamenten gegen diesen Protein-Komplex erleichter...

A new test might facilitate diagnosis and drug development for Alzheimer’s disease

26 Mar 2012 - An international team of researchers have developed a new method for measurement of aggregated beta-amyloid – a protein complex believed to cause major nerve cell damage and dysfunction in Alzheimer’s disease. The new method might facilitate diagnosis and detection as well as development of drugs directed against aggregated beta-amyloid....

Cognitive problems common among non-demented elderly

26 Mar 2012 - Both subjective and objective cognitive impairment are highly common among non-demented elderly Swedes, with an overall prevalence of 39 percent and 25 percent respectively, according to a nation-wide twin-study by researchers at the Aging Research Center of Karolinska Institutet, Sweden. The study confirms higher education as a major protective factor and stresses the importance of environmental ...

New hope for treating Alzheimer's Disease: A Role for the FKBP52 protein

21 Mar 2012 - New research in humans published today reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer’s drugs and for detecting the disease before the onset of clinical symptoms....

Scientists pinpoint how vitamin D may help clear amyloid plaques found in Alzheimer's

06 Mar 2012 - A team of academic researchers has identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer's disease. ...

Walnuts may boost Memory and Improve Cognitive Function

01 Mar 2012 - Do you recall what you ate for breakfast today or dinner last night? According to new research, you may have a better chance remembering if you had included walnuts. Recent findings published in the Journal of Alzheimer’s Disease report walnut consumption in a Mediterranean diet is associated with better memory scores and cognitive function. The results suggest that antioxidants present in walnu...

Nottingham scientists uncover new clues for early diagnosis of Alzheimer’s

07 Feb 2012 - Scientists in Nottingham have found abnormal levels of seven different proteins in spinal fluid could act as markers for detecting Alzheimer’s disease. The study, which was part-funded by Alzheimer’s Research UK, the UK’s leading dementia research charity, could lead to the development of a new test to detect the disease in its early stages....

New Study Challenges Accepted Approaches to Research in Senile Dementia (Alzheimer’s Disease)

07 Nov 2011 - Amsterdam, NL, 7 November 2011 – Impacting millions of families and devouring billions of dollars globally, Alzheimer’s disease is the focus of exhaustive research to find a cure. Although intensely investigated over the last three decades using cutting-edge technologies, the “pathogenic cause” of Alzheimer’s disease has not been found. While many research “breakthroughs” have been...

Could hypertension drugs help people with Alzheimer’s?

19 Oct 2011 - Within the next 20 years it is expected the number of people with Alzheimer’s disease (AD) will double from its current figure of half a million to one million. A new study has looked at whether certain types of drugs used to treat high blood pressure, also called hypertension, might have beneficial effects in reducing the number of new cases of Alzheimer’s disease each year. ...

Advances in Brain Imaging Can Expedite Research and Diagnosis in Alzheimer’s Disease

11 Oct 2011 - Alzheimer’s disease (AD) is a common problem that is becoming progressively burdensome throughout the world. A new supplement to the Journal of Alzheimer’s Disease, Imaging the Alzheimer Brain, clearly shows that multiple imaging systems are now available to help understand, diagnose, and treat the disease. ...

Blood tests may hold clues to pace of alzheimer’s disease progression

04 Oct 2011 - A team of scientists, led by Johns Hopkins researchers, say they may have found a way to predict how quickly patients with Alzheimer’s disease (AD) will lose cognitive function by looking at ratios of two fatty compounds in their blood. The finding, they say, could provide useful information to families and caregivers, and might also suggest treatment targets for this heartbreaking and incurab...

Scientists uncover new clues to Alzheimer’s risk gene that affects one in six

07 Sep 2011 - UK scientists have uncovered how a known risk gene for Alzheimer’s might play a role in the development of the disease. The study – which was funded by Alzheimer’s Society and Alzheimer’s Research UK – provides an exciting new area of investigation for researchers developing treatments and ultimately a cure for the disease. It is being published in the current issue of the Journal of Alz...

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