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This journal will publish review articles and original research that deal with a novel and very important area of biology. The ultimate objective is to understand the integrative regulation of higher organisms in their entire complexity. It has been firmly established already that the Nervous, Endocrine and Immune systems form a regulatory network, a Super-System, which governs all events from conception till death in higher animals and in man, including physiological and pathophysiological processes.

It follows from the above definition that a review journal covering this area of Biomedicine must operate in a “multidisciplinary” fashion. The rapidly accumulating and fragmented information available today will be collected, organized and interpreted; the elements, compounds, cells and tissues will be fitted into living organisms and our knowledge of the biology of such higher organisms will be enhanced. The rules of physiological interactions during homeostasis must be understood and also the regulatory interactions in diseases must be followed, which operate during pathophysiological conditions (allostasis).

One might raise the objection that Advances in Neuroimmune Biology aspire for too much and eventually will catch very little. This is why the editors have to examine carefully each topic and project. Yes, this science is multi-disciplinary, but they restrict themselves to study integrative mechanisms/pathways exclusively. If a topic/project does not deal with the subject area in an integrative manner, it will not be considered for publication.

A panel of outstanding scientists have given their support to this proposal and agreed to serve on the Editorial Board. The editors will review papers, will be expected to contribute articles, plan actively and edit certain issues, and will also be active in soliciting new articles from fellow scientists.

The primary audience will be scientists working in physiology, endocrinology, immunology, pathology, medicine and in similar areas of veterinary medicine and of biology. Zoologists should also be interested as lower animals also have integrative coordinating mechanisms to organize their biology. The secondary audience would come from doctors of medicine and veterinary medicine, practicing biologists, etc. At a certain level parents, even animal breeders, and the general public should also be interested. Amongst the problems this journal will present are the stress response and its biological significance. These questions have fundamental importance to modern society and to proper health care. Clearly, the systematic presentation of Neuroimmune Biology is very much in need in modern societies.

Unsollicited submissions should be submitted electronically to www.mstracker.com.

Note that the manuscript should be uploaded as one file with tables and figures included. This file can be a Microsoft Word document or an Adobe PDF.

All unsollicited articles will be peer-reviewed.

We recommend that the cover letter includes the names and email addresses of 3-5 potential reviewers knowledgeable in the area of the study and potential reviewer conflicts.

Letter of submission
The letter of submission should also include the following:

• Statement that all authors have contributed to the work, agree with the presented findings, and that the work has not been published before nor is being considered for publication in another journal.
• Statement of all financial and material support for this research and any potential conflicts. (These should also be clearly identified in the acknowledgement section of the manuscript).
• Resubmissions should include the manuscript number and a point-by-point response to the previous reviews in the cover letter.
  The point-by-point response can also be included at the beginning of the manuscript to maintain formatting.

Required files
After the article has been accepted, the following electronic files are required:

• a word processor file of the text, such as Word or LateX (If using LaTeX, please use the standard article.sty as a style file and also send a pdf version of the LaTeX file)
• separate files of all figures (if any); see "Preparation of manuscripts" for the required file formats

PREPARATION OF MANUSCRIPTS

Organization of the paper and style of presentation
Manuscripts must be written in English. Authors whose native language is not English are recommended to seek the advice of a native English speaker, if possible, before submitting their manuscripts. You can also visit www.internationalscienceediting.com. International Science Editing offers a language and copyediting service to all scientists who want to publish their manuscript in scientific peer-reviewed periodicals and books.

Manuscripts should be prepared with wide margins and double spacing throughout, including the abstract, footnotes and references. Every page of the manuscript, including the title page, references, tables, etc., should be numbered. However, in the text no reference should be made to page numbers; if necessary, one may refer to sections. Try to avoid the excessive use of italics and bold face.

Manuscripts should be organized in the following order:

• Title page
• Body of text (divided by subheadings)
• Acknowledgements
• References
• Tables
• Figure captions
• Figures

Headings and subheadings should be numbered and typed on a separate line, without indentation.

SI units should be used, i.e., the units based on the metre, kilogramme, second, etc.

Title page
The title page should provide the following information:

• Title (should be clear, descriptive and not too long)
• Name(s) of author(s); please indicate who is the corresponding author
• Full affiliation(s)
• Present address of author(s), if different from affiliation
• Complete address of corresponding author, including tel. no., fax no. and e-mail address
• Abstract; should be clear, descriptive, self-explanatory and not longer than 200 words, it should also be suitable for publication in abstracting services
• Keywords

Tables
Number as Table 1, Table 2 etc, and refer to all of them in the text.
Each table should be provided on a separate page of the manuscript. Tables should not be included in the text.
Each table should have a brief and self-explanatory title.
Column headings should be brief, but sufficiently explanatory. Standard abbreviations of units of measurement should be added between parentheses.
Vertical lines should not be used to separate columns. Leave some extra space between the columns instead.
Any explanations essential to the understanding of the table should be given in footnotes at the bottom of the table.

Figures
Number figures as Fig. 1, Fig. 2, etc and refer to all of them in the text.
Each figure should be provided on a separate sheet. Figures should not be included in the text.
Colour figures can be included, provided the cost of their reproduction is paid for by the author.
For the file formats of the figures please take the following into account:

• Line art should be have a minimum resolution of 600 dpi, save as EPS or TIFF
• Grayscales (incl photos) should have a minimum resolution of 300 dpi (no lettering), or 500 dpi (when there is lettering); save as tiff
• Do not save figures as JPEG, this format may lose information in the process
• Do not use figures taken from the Internet, the resolution will be too low for printing
• Do not use colour in your figures if they are to be printed in black & white, as this will reduce the print quality (note that in software often the default is colour, you should change the settings)
• For figures that should be printed in colour, please send a CMYK encoded EPS or TIFF

Figures should be designed with the format of the page of the journal in mind. They should be of such a size as to allow a reduction of 50%.
On maps and other figures where a scale is needed, use bar scales rather than numerical ones, i.e., do not use scales of the type 1:10,000. This avoids problems if the figures need to be reduced.
Each figure should have a self-explanatory caption. The captions to all figures should be typed on a separate sheet of the manuscript.
Photographs are only acceptable if they have good contrast and intensity.

Colour figures
It is possible to have figures printed in colour, provided the cost of their reproduction is paid for by the author. The charges will be specified with the proof delivery. Online the figures will be published in full color at no charge.

References
1. Place citations as numbers in square brackets in the text. All publications cited in the text should be presented in a list of references following the text of the manuscript. Only articles published or accepted for publication should be listed in the reference list. Submitted articles can be listed in the text as (author(s), unpublished data).
2. All authors should be listed in the reference list.
3. References must be listed in Vancouver style:

[1] Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002; 935(12): 406.
[2] Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA. Medical microbiology. 4th ed. St. Louis: Mosby; 2002.
[3] Berkow R, Fletcher AJ, editors. The Merck manual of diagnosis and therapy. 16th ed. Rahway (NJ): Merck Research Laboratories; 1992.
[4] Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGrawHill; 2002. p. 93113.
[5] Canadian Cancer Society [homepage on the Internet]. Toronto: The Society; 2006 [updated 2006 May 12; cited 2006 Oct 17]. Available from: http://www.cancer.ca/.

Footnotes
Footnotes should only be used if absolutely essential. In most cases it is possible to incorporate the information in the text.
If used, they should be numbered in the text, indicated by superscript numbers and kept as short as possible.

COPYRIGHT

Copyright of your article
Authors submitting a manuscript do so on the understanding that they have read and agreed to the terms of the IOS Press Author Copyright Agreement.

Quoting from other publications
An author, when quoting from someone else's work or when considering reproducing figures or table from a book or journal article, should make sure that he is not infringing a copyright. Although in general an author may quote from other published works, he should obtain permission from the holder of the copyright if he wishes to make substantial extracts or to reproduce tables, plates or other figures. If the copyright holder is not the author of the quoted or reproduced material, it is recommended that the permission of the author should also be sought. Material in unpublished letters and manuscripts is also protected and must not be published unless permission has been obtained. Submission of a paper will be interpreted as a statement that the author has obtained all the necessary permission. A suitable acknowledgement of any borrowed material must always be made.

PROOFS & PURCHASES

PDF Proofs
The corresponding author will receive a pdf proof and is asked to check this proof carefully (the publisher will execute a cursory check only). Corrections other than printer's errors, however, should be avoided. Costs arising from such corrections will be charged to the authors.

How to order reprints, a pdf file, journals, or IOS Press books
The corresponding author of a contribution to the journal is entitled to receive 1 copy of the journal free of charge, unless otherwise stated. Free copies will not be provided for conference proceedings and abstract issues. An order form for reprints, additional journal copies or a pdf file will be provided along with the pdf proof.

If you wish to order reprints of an earlier published article, please contact the publisher for a quotation. IOS Press, Fax: +31 20 6870039. Email: editorial@iospress.nl.

An author is entitled to 25 % discount on IOS Press books. See Author's discount (25%) on all IOS Press book publications.