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Study Demonstrates Mass Spectrometry Technique Dramatically Enhances Detection of Key Early Stage Alzheimer’s Biomarkers

October 12, 2016 - A peer reviewed study led by Proteome Sciences plc (“Proteome Sciences”), in conjunction with a group of highly respected universities and hospitals, demonstrates the ability of an innovative mass spectrometry (MS) workflow to dramatically improve the ability to detect tau-derived peptides that are directly related to human Alzheimer’s pathology as early stage biomarkers of the disease.

October 12, 2016

Online advice for preventing Alzheimer’s disease often problematic: UBC research

October 11, 2016 - New UBC research finds that many online resources for preventing Alzheimer’s disease are problematic and could be steering people in the wrong direction.

October 11, 2016

Specific Triazine Herbicides Induce Amyloid-β42 Production

September 15, 2016 - A new study led by Laurent Meijer, at ManRos Therapeutics, and collaborators shows that some herbicides (triazines) trigger enhanced in vitro production of the Aβ42 over Aβ40 amyloid peptides in various cell lines. This suggests that some products from the ‘human chemical exposome’ (HCE) (estimated to be over 85,000 products) may contribute to the increased production of Aβ42 over Aβ40 characteristic of Alzheimer’s disease (AD). In addition, some of these products might be turned into pharmacological tools to develop a chemically-induced animal model of AD (in contrast with the currently used genetic, recombinant mice models). Publication of these findings is scheduled in the Journal of Alzheimer's Disease, vol. 54(4) issue. This work is now continuing with special focus on (1) Persistent Organic Pollutants (POPs) and (2) defining conditions under which such products could trigger in vivo Aβ42 production in mice.

September 15, 2016

Markers associated with Alzheimer’s and Parkinson’s diseases are present in Mexico City children chronically exposed to concentrations of fine particulate matter PM2.5 above the current EPA USA standards

September 12, 2016 - A new study by researchers at the Universities of Montana, Valle de México, Boise State, Veracruz University, Médica Sur, Centro de Ciencias de la Atmósfera, UNAM, Hospital Regional de Alta Especialidad, Ciudad Victoria, Hospital de Especialidades #14, IMSS, Centre Hospitalier Universitaire, Hôpital de Hautepierre and AJ Roboscreen GmbH heightens concerns over the detrimental impact of fine particulate matter PM2.5 on CSF markers associated with Alzheimer and Parkinson’s diseases in children ages 11.9±4.8 years. These findings are published in the Journal of Alzheimer’s Disease.

September 12, 2016